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1.
1INTRODUCTIONTheIGBP-IHDP(InternationalGeosphere-BiosphereProgramme,andInternationalHumanDimensionPro-gramme)jointproject—LUCC(landuse/coverchange)isaninterdisciplinaryprogramdesignedtoimprovetheunderstandingofthedynamicsofland-useandland-coverchangeasinputstoandconsequencesofglobalenvironmentalchangeandsustainabledevelopment(CHARLOTTE,2002).Inparticularthedifferentbio-geochemicalmodeling(e.g.theglobalcarboncycle)ac-tivitiesandcomparativestudies,suchasthoseconduct-edbyIGBP-G… 相似文献
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青藏铁路多年冻土区保温护道路基温度场数值模拟研究 总被引:1,自引:0,他引:1
多年冻土区路基铺设保温护道的目的在于削弱边坡热侵蚀作用对路基下多年冻土温度状况的影响,防止多年冻土上限特别是阳坡侧冻土上限下降,减少人为活动对路堤坡脚及附近天然地表的破坏;防止路侧地表积水渗入基底;对边坡产生反压,防止路肩滑塌,以保证路基的稳定.结合试验工程监测资料,采用数值模拟方法分析了青藏铁路多年冻土区路基保温护道的效果,结果表明:保温护道并没有达到设计的目的,由于路基和护道几何形状对空气对流和太阳辐射的影响,不仅达不到保护冻土地基的目的,反而加大阴阳坡温度差异,导致路基病害的发生. 相似文献
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无锡市机构编制委员会在江苏省率先正式批复江苏省水文水资源勘测局无锡分局增挂“无锡市水文局”牌子,实行省市双重领导,以省为主管理体制,并明确了无锡市水文局为地方服务的七项职责。无锡水文在新的历史发展时期下,水文站网规划设计应该紧紧围绕无锡水利、服务无锡水利、融入无锡水利,才能发挥水文体制省市双重领导、以省为主管理的最大效益。 相似文献
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目的:基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法:通过基因表达汇编(GEO)数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体(GO)功能及京都基因与基因组百科全书(KEGG)通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果:骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶(MAPK)信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论:骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。 相似文献
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采用廉价的乳糖替代IPTG诱导重组别藻蓝蛋白(rAPC)在大肠杆菌(Escherichiacoli)JM109中表达,对诱导产物表达的培养基、培养条件、诱导剂的浓度和诱导时机进行了优化,将优化条件用于5L自控发酵罐进行高密度培养。结果表明,对rAPC表达的条件进行优化后,乳糖诱导rAPC的表达率可达26.8%,与IPTG的诱导结果接近;在高密度培养中,OD600最大达21.8。研究结果可为乳糖替代IPTG大规模生产rAPC奠定基础。 相似文献
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The ridge located between 31° S and 34°30′S is spreading at a rate of 35 mm yr−1, a transitional velocity between the very slow (≤20 mm yr−1) opening rates of the North Atlantic and Southwest Indian Oceans, and the intermediate rates (60 mm yr−1) of the northern limb of the East Pacific Rise, and the Galapagos and Juan de Fuca Ridges. A synthesis of multi-narrow beam,
magnetics and gravity data document that in this area the ridge represents a dynamically evolving system. Here the ridge is
partitioned into an ensemble of six distinct segments of variable lengths (12 to 100 km) by two transform faults (first-order
discontinuities) and three small offset (< 30 km) discontinuities (second-order discontinuities) that behave non-rigidly creating
complex and heterogeneous morphotectonic patterns that are not parallel to flow lines. The offset magnitudes of both the first
and second-order discontinuities change in response to differential asymmetric spreading. In addition, along the fossil trace
of second-order discontinuities, the lengths of abyssal hills located to either side of a discordant zone are observed to
lengthen and shorten creating a saw-toothed pattern. Although the spreading rate remains the same along the length of the
ridge studied, the morphology of the spreading segments varies from a deep median valley with characteristics analogous to
the rift segments of the North Atlantic to a gently rifted axial bulge that is indistinguishable from the shape and relief
of the intermediate rate spreading centers of the East Pacific Rise (i.e., 21°N). Like other carefully surveyed ridge segments
at slow and fast rates of accretion, the along-axis profiles of each ridge segment are distinctly convex upwards, and exhibit
along-strike changes in relief of 500m to 1500 between the shallowest portion of the segment (approximate center) and the
segment ends. Such spatial variations create marked along-axis changes in the morphology and relief of each segment. A relatively
low mantle Bouguer anomaly is known to be associated with the ridge segment characterized by a gently rifted axial bulge and
is interpreted to indicate the presence of focused mantle upwelling (Kuo and Forsyth, 1988). Moreover, the terrain at the
ends of each segment are known to be highly magnetized compared to the centers of each segment (Carbotte et al, 1990). Taken
together, these data clearly establish that these profound spatial variations in ridge segment properties between adjoining
segments, and along and across each segment, indicate that the upper mantle processes responsible for the formation of this
contrasting architecture are not solely related to passive upwelling of the asthenosphere beneath the ridge axis. Rather,
there must be differences in the thermal and mechanical structure of the crust and upper mantle between and along the ridge
segments to explain these spatial variations in axial topography, crustal structure and magnetization. These results are consistent
with the results of investigations from other parts of the ridge and suggest that the emplacement of magma is highly focused
along segments and positioned beneath the depth minimum of a given segment. The profound differences between segments indicate
that the processes governing the behavior of upwelling mantle are decoupled and the variations in the patterns of axis flanking
morphology and rate of accretion indicate that processes controlling upwelling and melt production vary markedly in time as
well. At this spreading rate and in this area, the accretionary processes are clearly three-dimensional. In addition, the
morphology of a ridge segment is not governed so much by opening rate as by the thermal structure of the mantle which underlies
the segment. 相似文献