Estrogenic responses of larval sunshine bass (Morone saxatilis x M. Chrysops) exposed to New York City sewage effluent

To determine the estrogenicity of effluents from sewage treatment plants (STPs) to larval fish, 2-day-old sunshine bass were exposed to effluents from three STPs serving New York City (NYC), varying in size and treatment level. Estrogenic response was evaluated by measuring vitellogenin (VTG) and estrogen receptor (ER) expression in cytosolic fractions of whole body homogenates. Concentrations of the presumptive endocrine disruptors in the effluents were also measured. VTG and ER levels in sewage-exposed fish were 3-5 times that observed in controls. Combined concentrations of estradiol and estrone ranged from 5 to 13 ng/l and nonylphenol-ethoxylate metabolites (NPEOs: 4-nonylphenol, and 1-, 2-, and 3-nonylphenol-ethoxylates) ranged from 180 to 470 microg/l in chlorinated effluent. Results indicate that both ER and VTG can be used as biomarkers for endocrine disruption in larval fish, and that 4-day exposure to sewage effluent is sufficient to elicit significant expression of these markers in sunshine bass larvae. The extremely higher concentrations of NPEOs found in effluent relative to hormones (approximately 40,000-fold) indicates that surfactant metabolites may be contributing significantly to the estrogenic effects observed.     

In-vitro metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by liver and intestinal mucosa homogenates from the winter flounder (Pseudopleuronectes americanus)

Freshly prepared homogenates were used to assess the relative ability of winter flounder (Pseudopleuronectes americanus) liver and intestinal mucosal cells to metabolize the polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BaP) and its proximate carcinogenic metabolite, BaP-7,8-dihydrodiol (7,8-Diol). Data obtained from homogenates prepared from fish previously fed β-naphthoflavone (BNF) indicated that both tissues had similar abilities to metabolize either BaP or 7,8-Diol on a per gram of protein basis. Metabolite profiles produced indicate that water-soluble metabolite formation is favored at low doses. These findings support the hypothesis that the intestine plays an important role in first-pass metabolism of dietary carcinogens in the winter flounder.     

Auroral recombination of N and O: A possible source for emission in the γ and δ bands of NO

Radiative recombination of N and O provides a significant source for auroral emission in the γ and δ bands of NO with selective population of vibrational levels in the A²Σ⁺ and C²Π states. This mechanism may account for emissions detected near 2150 Å. Models are derived for the auroral ionosphere and include estimates for the concentrations of N and NO. The concentration of NO is estimated to have a value of about 10⁸ cm^?1 near 140 km in an IBC III aurora. The corresponding density for N is about 5 × 10⁷cm^?3 and the concentration ratio $\text{NO}{}^{\mathrm{+}}\text{O}{}_2{}^{\mathrm{+}}$ has a value of about 5.5.     

Photochemistry of nitrogen in the Martian atmosphere

Models are developed for the photochemistry of a CO₂H₂ON₂ atmosphere on Mars and estimates are given for the concentrations of N, NO, NO₂, NO₃, N₂O₅, HNO₂, HNO₃, and N₂O as a function of altitude. Nitric oxide is the most abundant form of odd nitrogen, present with a mixing ratio relative to CO₂ of order 10^?8. Deposition rates for nitrite and nitrate minerals could be as large as 3× 10⁵ N equivalent atoms cm^?2 sec^?1 under present conditions and may have been higher in the past.     

Sources and sinks for atmospheric H2: A current analysis with projections for the influence of anthropogenic activity

Oxidation of CH₄ provides the major source for atmospheric H₂ which is removed mainly by reaction with OH. Biological activity at the Earth's surface appears to represent at most a minor sink for H₂. Anthropogenic activity is a significant source for both H₂ and CO in the present atmosphere and may be expected to exert a growing influence in the future. Models are presented which suggest a rise in the mixing ratio of H₂ from its present value of 5.6 × 10^?7 to about 1.8 × 10^?6 by the year 2100. The mixing ratio of CO should grow from 9.7 × 10^?8 to 2.3 × 10^?7 over the same time period and there should be a rise in CH₄ by about a factor of 1.5 associated with anthropogenically induced reductions in tropospheric OH.     

A numerical study of the nocturnal heat island over a medium-sized mid-latitude city (Columbus,Ohio)

A numerical investigation is conducted of the nocturnal heat island over Columbus, Ohio, a relatively flat mid-latitude city. Specifically, a cross-sectional steady-state numerical model to simulate the (thermal) structure of the nocturnal urban boundary layer is developed from a one-dimensional, time-dependent model due to Estoque. The model is applied to Columbus for special periods in September 1968 and March 1969 during which comparable experimental data were collected. The numerical simulations agree well with the observed data with respect to the detailed spatial form of the surface-based thermal boundary layer across the city. The use of the model for other metropolitan areas, for ascertaining the relative effect of city size and building geometry on the development of the thermal boundary layer, and for determining the effect of alternate land-use strategies on the thermal stratification are also discussed.Digest of portion of a dissertation submitted to the Pennsylvania State University in partial fulfillment of the requirements for the degree of Doctor of Philosophy.Presented in part at the Air Pollution, Turbulence and Diffusion Symposium, Las Cruces, New Mexico, 7–10 December 1971.On assignment from the National Oceanic and Atmospheric Administration (NOAA), U.S. Department of Commerce.     

颅脑外伤分类的CT特征

本文目的在于进一步提高对多种颅脑损伤的认识水平。所用材料和方法为本组１３５例,男９８例,女３７例,年龄４＿７７岁,平均年龄２４．８３岁。车祸伤９３例,跌伤２８例,击伤１４伤,１０１例有昏迷史,全部病例均作头颅ＣＴ轴位平扫。从相互伴发的多种颅脑损伤的角度,详细分析了它们的ＣＴ表现。结果得到了１３５例中,有多种类型颅脑损伤１３３例,单纯脑挫裂伤２例;硬膜外血肿１０４例,合并同一部位骨折７５例,占７２．１５％,合并脑挫裂伤占７０．３７％;硬膜下血肿２０例,位于外力对冲部位１５例．占７５％,合并脑挫伤裂伤１２例,其中１１例邻近硬膜下血肿;外伤后２小时内ＣＴ检查,并于外伤后４小时至５天内ＣＴ复查４７例,发现病变进展３８例,占８０．９５％。结论为硬膜外血肿多伴同部位骨折;在硬膜外血肿中,伴发的脑挫裂伤多位于对冲部位;硬膜下血肿多发生于对冲部位;颅脑损伤后,短期内病变可能会继续发展。     

Distribution functions for energetic oxygen atoms in the earth's lower atmosphere

Direct photolysis of O₃ and quenching of $\text{O}\text{(}{}^1\text{D}\text{)}$ by N₂ provide abundant sources of fast oxygen atoms for the Earth's lower atmosphere. The concentration of atoms with energy above 0.7 eV may exceed the concentration of $\text{O}\text{(}{}^1\text{D}\text{)}$ for all altitudes below 18 km and these atoms may play an important role in lower atmospheric chemistry. Distribution functions for $\text{O}\text{(}{}^3\text{P}\text{)}$ are given for the energy interval 0.1-1.3 eV, for a range of altitudes from 0 to 62 km.     

Stratospheric ozone: Impact of human activity

Current knowledge of the chemistry of the stratosphere is reviewed using measurements from the Atmospheric Trace Molecule Spectroscopy (ATMOS) experiment to test the accuracy of our treatment of processes at mid-latitudes, and results from the Airborne Antarctic Ozone Experiment (AAOE) to examine our understanding of processes for the polar environment. It is shown that, except for some difficulties with N₂O₅ and possibly ClNO₃, gas phase models for nitrogen and chlorine species at 30°N in spring are in excellent agreement with the data from ATMOS. Heterogeneous processes may have an influence on the concentrations of NO₂, N₂O₅, HNO₃, and ClNO₃ for the lower stratosphere at 48°S in fall. Comparison of model and observed concentrations of O₃ indicate good agreement at 30°N, with less satisfactory results at 48°S. The discrepancy between the loss rate of O₃ observed over the course of the AAOE mission in 1987 and loss rates calculated using measured concentrations of ClO and BrO is found to be even larger than that reported by Anderson et al. (1989, J. geophys. Res. 94, 11480). There appear to be loss processes for removal of O₃ additional to the HOC1 mechanism proposed by Solomon et al. (1986, Nature 321, 755), the ClO-BrO scheme favored by McElroy et al. (1986, Nature 321, 759), and the ClO dimer mechanism introduced by Molina and Molina (1987, J. phys. Chem. 91, 433). There is little doubt that industrial halocarbons have a significant impact on stratospheric O₃. Controls on emissions more stringent than those defined by the Montreal Protocol will be required if the Antarctic Ozone Hole is not to persist as a permanent feature of the stratosphere.