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1.
We have previously demonstrated that medaka CYP3A is associated with metabolism of several endobiotics including steroids and bile acids. In this study, we demonstrate that medaka CYP3A catalysis exhibits unusual kinetic behaviors consistent with allosteric interaction which cannot be described by hyperbolic kinetic models. Using 7-benzyloxy-4-(trifluoromethyl)-coumarin (BFC) and nonylphenol as CYP3A substrates, we describe both homotropic and heterotropic cooperative interactions. Given the role of CYP3A in maintaining the homeostatic balance for numerous endobiotics, enzymatic activation/inhibition by endocrine disruptors (EDCs) represents a putative (non-genomic) mechanism for endocrine disruption.  相似文献   
2.
Framvaren, a super-anoxic fjord in southern Norway, contains 7–8 mmoll−1 of sulphide and a total carbonate concentration of 18.5 mmol kg−1 in the bottom water. The chemistry of calcium has been studied, considering sources, biogenic and chemical processes and sedimentary sinks. Calcium associated with the bacteria biomass at the redox interface (18m depth) appears to be the primary source of dissolved calcium in the deep, anoxic water. Excess calcium and high total carbonate cause supersaturation of calcite, which is precipitated chemogenically. Calcite (and presumably some aragonite) is identified both in sediment trap material and the bottom sediments below the depth of supersaturation.  相似文献   
3.
The strength of the Sun's polar fields   总被引:3,自引:0,他引:3  
The magnetic field strength within the polar caps of the Sun is an important parameter for both the solar activity cycle and for our understanding of the interplanetary magnetic field. Measurements of the line-of-sight component of the magnetic field generally yield 0.1 to 0.2 mT near times of sunspot minimum. In this paper we report measurements of the polar fields made at the Stanford Solar Observatory using the Fe i line 525.02 nm. We find that the average flux density poleward of 55° latitude is about 0.6 mT peaking to more than 1 mT at the pole and decreasing to 0.2 mT at the polar cap boundary. The total open flux through either polar cap thus becomes about 3 × 1014 Wb. We also show that observed magnetic field strengths vary as the line-of-sight component of nearly radial fields.  相似文献   
4.
Yves Morel  Leif N. Thomas   《Ocean Modelling》2009,27(3-4):185-197
In this article, the authors study the influence of a constant wind on the displacement of a vortex. The well known Ekman current develops in the surface layer and is responsible for a transport perpendicular to the wind: the Ekman drift.An additional process is, however, evidenced, whose importance is as strong as the Ekman drift. There indeed exists a curl of the wind-driven acceleration along isopycnic surfaces when they are spatially variable (they enter and leave the depth where the wind stress acts), which generates potential vorticity anomalies. This diabatic effect is shown to generate potential vorticity anomalies which acts on the propagation of vortical waves and non linear vortices.It is shown that this effect drastically reduces the effect of the Ekman drift for linear waves and surface intensified vortices, while extending its effect to subsurface vortices. It also generates along wind propagation, whose sign depends on the vortex characteristics.  相似文献   
5.
Although W. Brunner began to weight sunspot counts (from 1926), using a method whereby larger spots were counted more than once, he compensated for the weighting by not counting enough smaller spots in order to maintain the same reduction factor (0.6) as was used by his predecessor A. Wolfer to reduce the count to R. Wolf’s original scale, so that the weighting did not have any effect on the scale of the sunspot number. In 1947, M. Waldmeier formalized the weighting (on a scale from 1 to 5) of the sunspot count made at Zurich and its auxiliary station Locarno. This explicit counting method, when followed, inflates the relative sunspot number over that which corresponds to the scale set by Wolfer (and matched by Brunner). Recounting some 60,000 sunspots on drawings from the reference station Locarno shows that the number of sunspots reported was “over counted” by \({\approx}\,44~\%\) on average, leading to an inflation (measured by an effective weight factor) in excess of 1.2 for high solar activity. In a double-blind parallel counting by the Locarno observer M. Cagnotti, we determined that Svalgaard’s count closely matches that of Cagnotti, allowing us to determine from direct observation the daily weight factor for spots since 2003 (and sporadically before). The effective total inflation turns out to have two sources: a major one (15?–?18 %) caused by weighting of spots, and a minor source (4?–?5 %) caused by the introduction of the Zürich classification of sunspot groups which increases the group count by 7?–?8 % and the relative sunspot number by about half that. We find that a simple empirical equation (depending on the activity level) fits the observed factors well, and use that fit to estimate the weighting inflation factor for each month back to the introduction of effective inflation in 1947 and thus to be able to correct for the over-counts and to reduce sunspot counting to the Wolfer method in use from 1894 onwards.  相似文献   
6.
High-resolution lithostratigraphy, mineral magnetic, carbon, pollen, and macrofossil analyses, and accelerator mass spectrometry 14C measurements were performed in the study of a sediment sequence from Lake Tambichozero, southeastern Russian Karelia, to reconstruct late-glacial and early Holocene aquatic and terrestrial environmental changes. The lake formed ca. 14,000 cal yr B.P. and the area around the lake was subsequently colonized by arctic plants, forming patches of pioneer communities surrounded by areas of exposed soil. A minor rise in lake productivity and the immigration of Betula pubescens occurred ca. 11,500 cal yr B.P. The rise in summer temperatures probably led to increased melting of remnant ice and enhanced erosion. The distinct increase in lake productivity and the development of open Betula-Populus forests, which are reconstructed based on plant macrofossil remains, indicate stable soils from 10,600 cal yr B.P. onward. Pinus and Picea probably became established ca. 9900 cal yr B.P.  相似文献   
7.
Comparison of the observed solar far ultraviolet irradiance and the observed solar sector structure during 1969 through 1972 shows a tendency for EUV maxima to be located near sector boundaries.  相似文献   
8.
Analysis of the green line corona for the interval 1947–1970 suggests the existence of largescale organization of the emission. The green line emission at high northern latitudes (≈ 40°–60°) is correlated with the emission at high southern latitudes 6, 15 and 24 days later, while the low latitude green corona seems to be correlated on both sides of the equator with no time lag. These coronal features are recurrent with a 27-day period at all latitudes between ± 60 °, and we associate these large-scale structures with the solar magnetic sector structure. The high correlation between northern and southern high-latitude emission at 15 days time lag is explained as a signature of a two-sector structure, while four sectors are associated with the 6 and 24 day peaks.  相似文献   
9.
The concentrations of total carbonate (Ct), sulphate, sulphide, thiols and oxygen, the ratio between the stable sulphur isotopes 34S and 32S in sulphate and sulphide, and the density (used to calculate salinity) were determined on samples from the water column of Framvaren, a superanoxic fjord in southern Norway. From a depth of 18m (the oxic-anoxic boundary) the initial sulphate concentration, ([SO4]init), as calculated from salinity, is significantly higher than the sum of the measured sulphur species. This is attributed to a loss of sulphur from the water column. The amount of total carbonate produced, corrected for the initial concentration (Ct - 2.4 Sal/35) is found to be proportional to the amount of sulphate consumed, ([SO4]init - [SO4]), according to the following relation Ct- 2.4 Sal/35 = 1.84 ([SO4]init - [SO4]). Isotopic fractionation caused by bacterial sulphate reduction in the anoxic part of the water column produces sulphide with a δ34S 40‰ lower than the δ34S for sulphate at corresponding depths. The isotopic fractionation also results in δ34S value for the remaining sulphate at depths below 80 m being considerably higher than the mean value for ocean water, which is close to + 20‰. The δ34S values for sulphate at depths between 10 and 50 m were lower than + 20‰ which indicates oxidation of sulphide, which follows upon diffusion of sulphide from deeper parts of the water column and inflow of oxygenated seawater over the sill into the anoxic water of the fjord. A conclusive scenario of the Framvaren sulphur chemistry is presented.  相似文献   
10.
Strong-motion recordings at 87 sites from 56 different intraplate earthquakes from North America, Europe, China and Australia have been used through a two-step regression analysis to develop new attenuation models for peak ground acceleration, and for pseudo-relative velocity for frequencies of 0.25, 0.5, 1.0, 2.0, 5.0 and 10.0 Hz, all for 5 per cent of critical damping. The estimates are obtained along with an analysis of residuals and scatter. A similar regression analysis has been performed also for Fourier spectra of acceleration, in which case the coefficient for the anelastic term has been interpreted in terms of a frequency dependent quality factor Q. The resulting Q-model shows a strong frequency sensitivity with values around 600–700 at 1 Hz, around 2000 at 10 Hz and around 5200 at 25 Hz. These PGA, PSV and Q results depend, however, on the underlying assumption for geometrical spreading, in particular for low frequencies.  相似文献   
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