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High-quality cultivation of specialized and sophisticated enterprises that produce new and unique products is an important starting point for consolidating the security foundation of China's industrial chain and supply chain. Using buffer zone analysis and the multi-scale geographically weighted regression (MGWR) model, this study explored the spatial distribution of specialized and sophisticated enterprises that produce new and unique products in the Yangtze River Delta region and influencing factors in 2021. The study found that: 1) Spatially, Shanghai is the main area where specialized and sophisticated enterprises that produce new and unique products are concentrated, followed by provincial capitals and cities on the coast and along rivers; The overall composition of the industry is unbalanced, and the real economic industries such as machinery and equipment manufacturing and high-tech manufacturing account for a relatively high proportion, but there are differences in different regions. 2) In terms of spatial agglomeration, differences between circles and the scale effect are obvious. Within each province, the spatial distribution of specialized and sophisticated enterprises that produce new and unique products in different cities is uneven. Region-wide, the overall spatial distribution pattern of "one pole and multiple cores" is evident. Shanghai is the main agglomeration area for these enterprises, and the provincial capital cities and cities that are the regional economic centers are the secondary agglomeration areas of these enterprises. 3) The four dimensions of influencing factors—physical geography, government, market, and society—have a scale effect on the spatial distribution of specialized and sophisticated enterprises that produce new and unique products. The degree of land development acts at a small scale, which is a local variable, and shows a large difference in the impact on the spatial distribution of these enterprises across the region. Factors such as elevation, government-business relationship, degree of marketization, number and scale of enterprises, degree of openness, logistics development level, and innovation environment are global variables, and except that the degree of marketization and the number of enterprises have a significant negative impact on the spatial distribution of these enterprises, the impact of all other factors is significantly positive. The research results can provide support for the optimization of the layout of new special expertise enterprise space in the Yangtze River Delta region, in order to provide reference for the formulation of new special expertise policies and industrial planning. © 2023, Editorial office of PROGRESS IN GEOGRAPHY. All rights reserved.  相似文献   
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