基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

中国对虾配合饲料限制性营养成分分析

以最常用的18种原料为对象,用线性规划的方法对华东沿海中国对虾人工饲料配制过程中的限制营养成分进行了分析。结果表明,粗脂肪、粗灰分、磷、精氨酸、赖氨酸是限制性营养成分,粗纤维和蛋氨酸在以植物性蛋白质为主的配方中是限制性营养成分。因此,在中国对虾人工饵料配方设计中,应注意选用脱脂原料,增加矿物质添加剂中磷的含量以及采用富含精氨酸和赖氨酸的原料。     

南海北部—观测点内潮特征的初步分析

采用功率谱分析、调和分析等方法，对南海北部－观测点连续９ｄ（１９８８年５月８—１６日）的温度。盐度和海流及跨越该期间较长的（１９８８年４月２４日－７月２２日）潮位资料进行了分析研究。结果表明，观测点存在着一种内潮现象，其波动的周期在２４ｈ左右，它传播的方向大体是偏北。     

海洋植物营养素的应用研究 Ⅰ.金藻类的培养

用不同含量的93－B型海洋植物营养素对几种常用的金藻类饵料种进行培养对比试验。结果表明,海洋植物营养素用于培养金藻类效果良好,最适使用含量为30mp·L~-1域40mg·L~-1。此时效果与通常被推荐的培养液所培养的对照组相当或更好．含量过高,则造成某些营养盐过量而产生一定的毒害作用。此营养素使用简便。     

轨道交通下立交区间基坑降水技术

根据下立交区间基坑特点,合理制定基坑工程降水方案。经工程实践证明,通过疏干井、混合井、降压井的合理设置,联合使用,科学有效地治理了地下水,较好地控制了因降水产生的工程风险。     

新疆天山地区地貌分形与多重分形特征研究

利用投影覆盖法和投影覆盖概率对新疆天山地区不同构造地貌类型进行了分形与多重分形特征的研究。结果表明：在所研究的标度范围内，不同地貌区均表现出明显的多度域分形，分维值总体上呈现出高山区＞中低山区＞盆地区特点，多重分形谱Dq的形态和值域范围也表现出不同特征。研究认为，地貌表面的分维值与地貌形成的内外力地质作用方式和强度密切相关，并提出5-6km的尺度可作为地貌学研究中宏观与微观作用的分界点。     

Flexural subsidence by 29 Ma on the NE edge of Tibet from the magnetostratigraphy of Linxia Basin, China

This study provides a detailed magnetostratigraphic record of subsidence in the Linxia Basin, documenting a 27 Myr long sedimentary record from the northeastern edge of the Tibetan Plateau. Deposition in the Linxia Basin began at 29 Ma and continued nearly uninterruptedly until 1.7 Ma. Increasing rates of subsidence between 29 and 6 Ma in the Linxia Basin suggest deposition in the foredeep portion of a flexural basin and constrain the timing of shortening in the northeastern margin of the plateau to Late Oligocene–Late Miocene time. By Late Miocene–Early Pliocene time, a decrease in subsidence rates in the Linxia Basin associated with thrust faulting and a 10° clockwise rotation in the basin indicates that the deformation front of the Tibetan plateau had propagated into the currently deforming region northeast of the plateau.     

The Origin and Evolution of Silica-saturated Alkalic Suites: an Experimental Study

Experimental simulation of incremental crystal fractionationof a hy-normative hawaiite indicates that the spectrum of compositionsfrom mildly alkalic hawaiite to sodic rhyolite found in silica-saturatedalkalic suites of the ocean islands and continental hotspotsand rifts can be produced by fractionation at 9·3 kbarwith bulk water contents >     

视电阻率观察中一种抗介质干扰的尝试

埋地金属管线对视电阻率的观测危害甚大。造成观测值大幅改变，跳动，无规律可循。严重时，甚至台站报废，被迫搬迁。通过一些突发事件的启发，结合现场实验，并引证了一些理论计算，笔者摸索出了只须对金属管道作局部微小的改造，就能基本克服其对观测的干扰的方法。该方法在红格台试验半年多来，取得了明显的效果。观测值恢复到安装的水管以前的水平，再无大幅度的跳动。该方法节约经费，简单易行，大大提高了台站在复杂环境中的生存能力。     

On the applicability of KirchofPs law and the principle of heat balance in thermal infrared remote sensing:A non-isothermal system

This paper proposes a basic equation of thermal radiation interaction between surface objects on the basis of the principle of heat balance in the interface. The solution of this equation takes account of the contribution of sensible heat flux and latent heat flux more completely, compared with traditional solution for surface cooling and heating processes. By the aid of the experimental data conducted in the Xiaotangshan experimental site, Beijing, both the non-applicability of Kirchoff's law and the measurability of surface emissivity in a non-isothermal system have been highlighted. Two methods called ventilation and time-delay compensations have been proposed to reduce the error induced by change of surface temperatures of non-isothermal objects during the measurement of emissivity. Based on the solution of the basic equation, this paper has analyzed and pointed out the misunderstanding in comprehension and application of Kirchoff's law published in literature.