基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

A NUMERICAL MODEL OF PHYTOPLANKTON BIOMASS IN THE CENTRAL WATERS OF SOUTH CHINA SEA

The present study is based on the materials collected from the middle waters of the South China Sea between 12°-15°N and 111°-118°E during May to July in 1978.The biomass of the phytoplankton (Y, dependent variable) is established to give the biomass of each Species and the environmental factors (i. e. water temperature, salinity, oxygen, silicate and phosphate contents), X1,X2...,X139tt are independent variables that are used to stepwisc regression analysis. Accordicg to the mathematical tests and the practical experience by which a lot of species are deleted and added to the equation, the authors consider that the 4th equation as shown below is optimal one for the model of the biomass on the phytoplankton from this waters.The optimal equation refers to text.     

基于退火BP神经网络的GPS高程转换

阐述模拟退火算法的基本思想和原理,提出并介绍模拟退火算法优化的BP神经网络模型在GPS高程转换中的具体应用,同时编写相应的MATLAB处理程序,结合大量数据进行仿真实验,结果表明文中提出的退火BP神经网络模型具有收敛速度快、精度高、避免陷入局部最小的优良特性。     

数字电子水准仪检定方法的研究

针对目前数字电子水准仪的检验仍然拘泥于光学模拟水准仪检验方法的现状,提出以完全根据仪器示值来评价水准仪精度性能的检验方法.     

井间电阻率层析成象的某些进展

用有限元法作电阻率层析成象的核心问题是Ｊａｃｏｂｉ矩阵的求取和反演成象算法的研究。本文主要论述了这两方面的最新进展，即求取Ｊａｃｏｂｉ矩阵的格林函数法，用于反演成象计算的平滑度约束反演。文中通过理论模型的成象计算，比较了两种反演算法的成象效果。     

一个被动大陆边缘的“开”“合”史及找矿标志——以赣西北震旦系至下古生界为例

本文根据赣西北地区震旦系至志留系基本层序和板内构造演化,可把古板块构造发展划分为4个阶段:开裂期(Z_1l-Z_2p)以中、小规模的重力流和凝缩段为特征;成熟发展期(∈_1-∈_3~1),以沉降沉积作用为主;萎缩期(∈_3~2-O_2h)以大规模重力流和混生动物群为特征;闭合期(O_3-S_3)以双幕式沉积为特征。同时阐述了在板块发展的各个阶段,不能忽视其成矿作用。     

Electric Field Effects on Animals:Mechanism of Seismic Anomalous Animal Behaviors (SAABs)

Electric field effect on animals has been studied to investigate its relation with seismic anomalous animal behaviors(SAABs)in China.Freshwater eel,crucian carp,catfish,and soft-shelled turtle responded to the threshold electric field of 1-10 V/m,while duck,goose,cat,sheep,pig,dog,and chicken all responded to the ground electric field of about tens of V/m,depending on the species as well as on individuals.Most of the behaviors caused by electric field were similar to those reported as SAABs such as alignment,sudden movement,panic,and convulsion.The intensity of electric field due to a major earthquake would have been over these threshold values.Numerical estimation based on an electromagnetic model of a fault has been made to induce SAABs as electric shocks to pulsed electric fields in electro-physiology.The seismic electric signals(SES)intensity might be estimated from the observation of SAABs.     

Chemical composition of upper crust in eastern China

In an area of 3.3×10⁶ km² within eastern China, 28 253 rock samples were collected systematically and combined into 2718 composite samples which were analyzed by 15 reliable methods using national preliminary certified reference materials (CRMs) for data quality monitoring. The average chemical compositions of the exposed crust, the sedimentary cover and the exposed basement as well as the upper crust for 76 chemical elements in eastern China are given. A key basic geology projcct supported by Ministry of Geology and Mineral Resources of China.     

新兴边缘学科——GPS气象学

阐述了GPS气象学的基本原理和GPS气象学的广阔应用领域，并介绍了GPS气象学的分类。     

Structural features and petroleum geology of the fold-thrust belt in the southern Tarim basin, China

The west Kunlun fold-thrust belt (WKFTB) and the Altun fold-thrust belt (AFTB) are respectively located in the southern margin of the Tarim basin, NW China. The analyses of typical structures and regional dynamics of the fold-thrust belts reveal their different structural and petroleum features and mechanisms. WKFTB differs from AFTB by abundant fault-related folds and triangles zones, and was formed by northward extrusion of the west Kunlun orogen. AFTB was affected synchronously by northward extrusion of the Altun orogen and the sinistral strike-slipping of the Altun Fault, so it is characterized by the minor scale and the monotonous structural styles. The Aqike anticline and the Aqike fault, of which the strikes are orthogonal to the strike of the fold-thrust belts, are regarded as the adjustive structures between both of the fold-thrust belts. The oil-gas pools of WKFTB develop mainly in the faulted-related anticline traps, but the oil-gas pools of AFTB develop mainly in the low fault-block and anticlines traps related with the paleo-uplifts. There are different exploration countermeasures for both of the fold-thrust belts.