β-1, 4-半乳糖基转移酶抑制剂的研究进展

β-1,4-半乳糖基转移酶(β-1,4-GalT)抑制剂的研究是当今糖化学和糖生物学的前沿研究领域之一。本文就β-1,4-GalT抑制剂(包括供体类似物、受体类似物、过渡态类似物)的设计、合成及活性评价诸方面予以综述。     

Study on Strength Influence Mechanism of Fiber-Reinforced Expansive Soil Using Jute

This study was undertaken to research the effects of jute fiber content, fiber length, water content and dry density of reinforced and unreinforced soil on the strength influence mechanism by implementing a series of laboratory tests and analysis. The most efficient fiber reinforcement effects was achieved by means of adding jute fiber with content of 0.6 % and length of 6 mm into expansive soil specimen prepared at maximum dry density and optimum moisture content. The cohesion of reinforced specimens increased first with increasing fiber content and fiber length and then decreased with further increase in fiber content and fiber length. The internal friction angle of reinforced specimens were not affected significantly by fiber content and fiber length. Higher water content reduces the fiber reinforcement effects by means of acting as lubricant in the interface of fiber and soil particles. Fiber reinforcement effects is more prominent for specimens prepared at higher dry density by increasing the effective contact area of fiber/soil. The application prospect of soil reinforcement using natural fiber is impeded by the hydrophilic nature and biodegradability of natural fiber, thus, studies on using chemical additive to do surface treatment for natural fiber are needed to improve the interfacial interaction of fiber/soil so as to widen the application of natural fiber.     

南海北部陆缘新生代玄武岩地球化学特征及成因

南海盆地及周缘地区新生代玄武岩对揭示南海盆地的演化历史至关重要,然而这些玄武岩的成因还存在争议。本文研究了位于南海北部陆缘的海南岛临高县多文组玄武岩岩石地球化学和矿物地球化学特征,并探讨其成因和构造背景。多文组玄武岩主要由橄榄石、单斜辉石、斜长石、斜方辉石、铬尖晶石和铁钛氧化物等组成。橄榄石Fo值变化于55.5～71.1之间,Ni的含量较低,Fe/Mn比值较高。铬尖晶石Cr^#值为74.1～82.7,Mg^#值为45.5～63.8, Ti的含量较高。斜方辉石Mg^#值为63.9～79.6,单斜辉石为66.0～80.6。单斜辉石稀土配分曲线富集MREE,亏损LREE和HREE,呈拱形分布。斜长石以中-拉长石为主(Ab_{36.56～52.78}),富集LREE、Ba、Sr和Eu。铁钛氧化物的TiO₂含量为50.19%～51.46%。多文组玄武岩原始岩浆的主量和微量元素组成与夏威夷、峨眉山、塔里木等玄武岩组成一致,地幔源区包含了辉石岩的成分,而且其地幔潜在温度(>1400℃)和氧逸度(Δ...     

Total Synthesis of Marine Cyclic Enol-Phosphotriester Salinipostin Compounds

Due to their structural diversity and variety of biological activities, marine natural products have been the subject of extensive study. These compounds, especially phospholipid polycyclic aromatic hydrocarbons, have a wide range of pharmacological applications, including embedded DNA and central nervous system, anti-tumor, anti-virus, anti-parasite, anti-bacterial, and antithrombotic effects. Unfortunately, the insufficient drug sources have limited the development of these compounds. In this study, we isolated salinpostin compounds from a fermentation solution of marine-derived Salinospora sp., which has a common bicyclic enol-phosphotriester core framework, as well as potent and selective antimalarial activities against P. falciparum with EC_(50)=50 nmolL~(-1). The chemical synthesis of these compounds in greater quantities is necessary for their use in bioactivity studies. Thus we explored a short route with high yields and mild reaction conditions, which can generate combinatorial libraries for drug discovery and lead optimization. We developed a new total synthesis method for six cyclic enol-phosphotriester salinipotin compounds and their diastereomers. For the total synthesis of cyclipostin P, we prepared cyclic enol-phosphotriester salinipostin compounds in 10 steps from a readily accessible starting material, 1,3-dihydroxyacetone, and obtained an overall yield of 1.29%. We fully characterized these compounds by proton nuclear magnetic resonance(~1H-NMR), carbon-13 NMR(~(13)C-NMR), and high-resolution mass spectrometry(HRMS) analyses, and found they coincide absolutely with the same compounds reported previously.     

鄂西-渝东地区热史恢复及烃源岩成烃史

根据鄂西—渝东地区镜质体反射率数据进行的热史恢复结果表明:该区在晚二叠世初期达到最高古热流(可达68~78mW/m²,地表热流),从晚二叠世初到现今古热流持续降低,在侏罗纪末期古热流平均为~54mW/m²(地表热流);鄂西—渝东地区中生界与新生界之间不整合面的剥蚀量可达1700~4000m。成烃史研究表明:鄂西—渝东地区志留系烃源岩在晚志留世—早二叠世进入生油高峰,在早-中三叠世进入生气期,中侏罗世晚期进入过成熟干气阶段,快速生烃时期是在晚志留世、二叠纪—中三叠世及早-中侏罗世;而二叠系烃源岩在早三叠世进入生油门限,于中-晚三叠世达到生油高峰,在中-晚侏罗世进入生气期,晚侏罗世晚期进入过成熟,快速生烃时期是在早-中三叠世及侏罗纪。     

热流测量中垂向地下水运动干扰的校正方法

本文提出了一种地表热流测量中垂向地下水干扰的校正方法。并以江西萍乡和福建安溪的二个钻孔为例,说明了热流校正的具体过程。由于地下水对流传热的影响,垂向地下水渗透层内温度和热流随深度均呈指数分布。通过对钻孔测温数据的一维垂向Peclet数分析,可以确定渗透层内传导和对流热流分量以及热流的构成,从而得到未受地下水对流干扰的区域背景热流。这一方法不仅适用于渗透率结构均一的介质,也可用于水平层状介质。     

福建省西部大地热流值

根据福建省西部53个钻孔的实测地温数据和300多块岩石样品的实测热导率数据,计算了29个大地热流值,说明福建西部热流的平均值为74mW/m²,相当于中新生代活动区的热流值。     

中国地热研究的进展与展望(1995～2014)

地热是主要地球物理场之一,地热能是地球的本土能源。李四光在20世纪60年代开创了我国地热科学。到90年代,学科体系基本建立。在过去20年里,我国地热研究得到了进一步深化和拓展。本文从大地热流、岩石圈热结构、地热系统、油气盆地地热、矿山地热、天然气水合物以及气候变化等方面回顾地热研究代表性的创新进展,并对深层地热、海洋地热、环境地热等研究方向作了展望。本文认为,过去20年我国地热研究成果丰硕,国际影响力得到提高,未来发展势头强劲。在经历了由浅入深,从今到古的成长之后,地热研究还将不断拓展领域,为我国地球科学,特别是能源与环境安全做出更大贡献。     

中国深层地热能开采的地质条件评价

深层地热能是指深度大于3 000 m的地热能。我国深层地热能资源丰富,但是开采条件怎么样呢?本文基于地热地质学原理,结合岩石力学等相关学科的理论,提出一种对深层地热能开采条件进行评价的指标体系,对各单一指标采用专家打分的方法赋值,继而采用模糊数学定量计算和评估深层地热能资源开发的难易程度。该方法考虑了深层地热能开发利用中的增强地热系统(EGS)的环境安全问题,即传统的“刚性造储”可能带来的诱发地震等不利于地热能行业健康发展的因素,倡导“柔性造储”和广义EGS理念,强调储层属性和地物理场的整合,针对我国地热能分布与构造活动关系密切、地壳总体上活动性强、地应力高、地震频发等构造型地热特点,是对以往评价方法的补充和拓展。该方法充分利用了专家知识,发挥了模糊数学综合评估作用,给出的量化结果易于对比和使用,可以更好地支持决策。本文基于新的评估方法,利用现有的深部地热研究及勘探成果,评估了中国大陆地区九个区域深层地热能开发的难易程度,评价区包括西藏南北地堑系、云南西部火山型地热区、青海东部共和盆地以及东北、华北等。从本文的结果可以看出,我国深层地热能开采的地质条件复杂,开采难度较大。     

Structures of the Bohai Petroliferous Area, Bohai Bay Basin

This paper, for the first time, deals with a more systematic study of the structures in the Bohaipetroliferous area that covers nearly one third of the Bohai Bay basin. The study mainly involves the effects of preexisting basement faults on the basin formation, the characteristics of basin geometry and kinetics, the modelling of the tectonic-thermal history, the polycyclicity and heterogeneity in the structural evolution and the natural seismic tomographic images of the crust and upper mantle. The authors analyze the features of the dynamic evolution of the basin in the paper and point out that the basin in the Bohai petroliferous area is an extensional pull-apart basin.