Effects of beta-naphthoflavone on hepatic biotransformation and glutathione biosynthesis in largemouth bass (Micropterus salmoides)

We are investigating the effects of in vivo exposure of prototypical enzyme inducing agents on hepatic biotransformation enzyme expression in largemouth bass (Micropterus salmoides), a predatory game fish found throughout the United States and Canada. The current study targeted those genes involved in biotransformation and oxidative stress that may be regulated by Ah-receptor-dependent pathways. Exposure of bass to beta-naphthoflavone (beta-NF, 66 mg/kg, i.p.) elicited a 7-9-fold increase in hepatic microsomal cytochrome P4501A-dependent ethoxyresorufin O-deethylase (EROD) activities, but did not affect cytosolic GST catalytic activities toward 1-chloro-2,4-dinitrobenzene (CDNB) or 5-androstene-3,17-dione (ADI). Glutathione S-transferase A (GST-A) mRNA expression exhibited a transient, but non-significant increase following exposure to beta-NF, and generally tracked the minimal changes observed in GST-CDNB activities. Expression of the mRNA encoding glutamate-cysteine ligase catalytic subunit (GCLC), the rate-limiting enzyme in glutathione (GSH) biosynthesis, was increased 1.7-fold by beta-NF. Changes in GCLC mRNA expression were paralleled by increases in intracellular GSH. In summary, largemouth bass hepatic CYP1A-dependent and GSH biosynthetic pathways, and to a lesser extent GST, are responsive to exposure to beta-NF.     

层间氧化带砂岩型铀矿稀土元素变化规律初探——以伊犁和吐鲁番-哈密盆地为例

本文以发育层间氧化带砂岩型铀矿的伊犁、吐鲁番—哈密盆地为例,详细研究了成矿层间氧化带稀土元素的分布特征和稀土元素在层间氧化作用中的变化规律。通过与北美页岩、还原带原生砂岩的对比,研究了稀土元素在不同氧化分带中的变化情况,结果表明在层间氧化作用过程中,稀土元素在总体亏损的背景上发生了明显的分异,LREE从氧化带到过渡带含量逐步降低,HREE由氧化带到过渡带趋于富集;δCe由氧化带到过渡带随氧化作用的减弱降低,δEu则逐步升高,呈现与表生风化作用相同的变化规律,较好地指示了层间氧化带中氧化—还原环境的变化。虽然稀土元素存在一定的迁移变化,但没有中亚砂岩铀矿床出现的REE显著迁移,高度富集现象。     

公婆泉盆地下白垩统新民堡群层序地层和铀成矿特点

本文论述了公婆泉盆地下白垩统新民堡群的层序地层特点———层序分布和时代、界面特征和内部构成、沉积相,以及层间氧化带和铀矿化特点。认为该盆地在公婆泉地段具有一定的找铀矿远景,但北骆驼泉地段铀成矿条件不佳,那林疏怀地段不具备铀成矿远景。     

潜育型砂岩铀矿化的地球化学特征、成因机理及找矿模式探讨──以红井铀矿床为例

产于红色碎屑岩中的红井铀矿床是潜育型砂岩铀矿化的一个典型例子。本文通过对红井铀矿床地球化学特征的研究,探讨了该类铀矿化的成因机理,并提出了“红层-断裂-油气-铀源”“四位一体”的找矿模式。     

南极冰冻圈融化速度减缓?

南极大陆温度正在升高,但是其冰冻圈融化速度比之前预测的速度要慢许多.事实上,有关该地区的卫星数据显示,南极大陆在去年夏天的融化速度就是近30年来最慢的一年.两位冰河专家在美国地球物理学联盟(American Geophysical Union)周报EOS上发表文章对这个看似矛盾的现象进行了解释.