The Statistical Analysis of Migration of Strong Earthquakes-Taking the North China Region as an Example

The migration of strong earthquakes is an important research topic because the migration phenomena reflect partly the seismic mechanism and involve the prediction of tendency of seismic activity. Research on migration of strong earthquakes has mostly focused on finding the phenomena. Some attempts on getting regularity were comparatively subjective. This paper suggests that there should be indices of migration in earthquake dataset and the indexes should have statistical meaning if there is regularity in the migration of strong earthquakes. In this study, three derivative attributes of migration, i.e., migration orientation, migration distance and migration time interval, were statistically analyzed. Results in the North China region show that the migration of strong earthquakes has statistical meaning. There is a dominant migration orientation (W by S to E by N), a dominant distance (≤100km and on the confines of 300～700km), and a dominant time interval (≤1a and on the confines of 3～4a). The results also show that the migration will differ slightly with different magnitude range or earthquake activity phase.     

电测深ρ＿s差值法的应用效果

用电测深研究地电断面、寻找隐伏多金属矿体时，以往采用ρ＿ｓ（或η＿ｓ）等值线断面图进行地质推断解释，因受浅源信号的干扰，效果差。本文提出了采用ρ＿ｓ（或η＿ｓ）差值法，能排除浅源干扰信号，反映出地电断面的相对变化，突出了深部微弱信息，取得了较好的地质解释效果。     

Design of stable drainage networks in upland forestry plantations

Erosion of man-made, forestry drainage channels occurs when the plough cuts through the surface peat layer into the underlying erodible mineral soil. A procedure is developed, based on hydraulic considerations, which will allow the drainage engineer to design stable drainage networks in upland forestry plantations. An example design chart is given for an erodible sandy loam type soil.     

宁远保安地区基性─超基性火山岩基本特征

本文论述了保安地区火山岩的地质、岩石、副矿物、岩石化学、微量元素、稀土元素、稳定同位素、火山岩相及火山机构等特征。并对其演化规律、形成机制与成矿作用的关系，作了初步探讨。     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

Freshening of the Intermediate Waters in the Northern South China Sea over the PastSix Decades

The properties of salinity in the South China Sea (SCS), a significant marginal sea connecting the Pacific andIndian Oceans, are greatly influenced by the transport of fresh water flux between the two oceans. However, the long-termchanges in the intermediate water in the SCS have not been thoroughly studied due to limited data, particularly in relationto its thermodynamic variations. This study utilized reanalysis data products to identify a 60-year trend of freshening in theintermediate waters of the northern South China Sea (NSCS), accompanied by an expansion of low-salinity water. Thestudy also constructed salinity budget terms, including advection and entrainment processes, and conducted an analysis ofthe salinity budget to understand the impacts of external and internal dynamic processes on the freshening trend of theintermediate water in the NSCS. The analysis revealed that the freshening in the northwest Pacific Ocean and theintensification of intrusion through the Luzon Strait at intermediate levels are the primary drivers of the salinity changes inthe NSCS. Additionally, a weakened trend in the intensity of vertical entrainment also contributes to the freshening in theNSCS. This study offers new insights into the understanding of regional deep sea changes in response to variations in boththermodynamics and oceanic dynamic processes.     

基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

To afforest the desert with the technology of peat composed of rotten mosses and the sustainable development of the oases

Only by providing the good conditions for the growth of plants can a favorable ecologicalenvironment on which human beings rely for existence be created. The upside-down-T dou-ble-layer water-conserving afforestation way is developed according to the situation of the short-age of water resources, low soil fertility and vast land in the arid areas. The characteristics of theafforestation way are to change the microenvironment in the root area of the plants, provide thefavorable conditions for the growth of plants, and reduce the necessary conditions for the growth ofplants in large areas in the arid regions. Meanwhile, the size of its water-conserving layer can bechanged according to the size of the planted trees. The different ways of the bottom wa-ter-conserving layer can be used according to the requirements. The afforestation way is suitablefor planting trees on a small scale and also for afforesting on a large scale under the adverse cir-cumstances in the arid areas, and has been effectively used in the afforestation in the hinterland ofTaklamakan Desert and the southern marginal zone of Gurbantonggut Desert. The prospects ofthe afforestation way are broad in afforestation and desertification control in the desert regions.     

山岳型旅游区人文建筑环境后效与调控模型

许多山岳型旅游区内或其流域上游，都建有人文建筑，而且在急剧增多，导致自然环境日趋恶化，其中乱建疗养院和旅馆的影响最为严重。通过地监测并全面分析张家界环境演变趋势，发现住宿施对环境的影响，比其他游乐设施更为明显。张家界国家森林公园生态环境的脆弱因子是金鞭溪水质。金鞭溪水质恶化主要表现为蓝藻，绿藻迅速繁殖，感官质量下降。主要原因是磷污染较重，总磷年均值100%超标。本文提出了基于环境脆弱因子的动态阈值调控模型，通过计算得出：在不超出张家界景区最为脆弱的环境因子-金鞭溪水质标准：总磷≤0.02前提下，金鞭溪上游接待区住宿设施生态阈值的动态系列：春季临界床位数为1186，夏季为3057，冬季为545，秋季为333。目前的建筑规模已超过了金鞭溪上游接待区住宿设施生态阈值。