滦河三角洲砂坝-潟湖海岸环境的遥感分析与区域开发潜力的评价

本文就不同类型淀湖在不同时相条件下,对卫星遥感谱段响应的分析结果,将研究区的信息进行了提取与复合.继之,解译了封闭与半封闭漏湖的发育进程和表观特征,并就七个潟湖区段环境乃至开发前景作了详细的阐述.     

Behavior of Pile Groups under Lateral Load

Based on investigation and model tests, and in combination with the research work on group effect for pile groups under lateral loads relating to the code of fixed offshore platforms, a series of studies have been performed on the behavior and failure mechanism of laterally loaded pile groups, critical pile spacing inducing group effect, lateral bearing capacity of pile groups and its main influence factors, the stress-strain relationship for single piles and pile groups and so on. Some new laws about non-uniformity of load distribution in the longitudinal direction of pile groups and load-deflection (p - y) curves for pile groups have been discovered, and an empirical formula is presented in order to remedy the defect of current calculating methods at home and abroad. These results can be used for reference in the design of pile foundation under lateral loads.     

Low-frequency damping of a moored semisubmersible obtained from simulated extinction tests and mean wave drift forces

Low-frequency damping of a moored semisubmersible drilling platform was obtained from numerical extinction tests simulated in still water and in regular waves and from mean wave drift forces calculated at zero forward speed. The influence of drag forces was represented by the modified Morison equation. The platform as used for the 18th ITTC Comparative Mooring Study was analyzed in irregular beam waves. The computed time series of sway as well as the corresponding sway response spectrum compared favourably with model test measurements, demonstrating that this procedure to determine low-frequency damping can be effective.     

超短基线声学定位原理及其应用

声学定位系统（Acoustic Positioning System)的技术研究和应用开发在现代海洋科学调查中起着重要作用。以挪威Simrad公司的HPR410P超短基线定位系统为例，从几方面讨论了超短基线（Ultrashort Baseline)声学定位系统的原理、应用范围、定位误差来源及其相应的修正方法；通过最大程度地减少误差来提高系统的定位精度，从而获取高质量的海洋科研调查资料。     

动荷载作用下海底粉土的孔压响应及其动强度

本文选用近海分布较广的粉土为研究对象 ,利用室内动三轴试验结果 ,找出动荷载作用下粉土的动应力应变关系 ,分析模拟波浪荷载作用下粉土中的孔压响应、临界循环次数 ,确定波浪作用下粉土的应力状态、破坏临界循环次数 ,判断不同深度处的粉土发生液化的可能性及发生液化所需要的时间 ;研究粉土在动荷载作用下的强度降低 ,为海上工程设计和施工提供科学依据。     

莺歌海盆地形成与演化的动力学机制

莺歌海盆地位于印支半岛与南海北部大陆边缘交接区,复杂的地质构造背景使其形成演化的动力学机制成为国内外的研究焦点。从区域动力学演化的角度,系统分析了影响莺歌海盆地发育的印支地块构造演化特征,认为莺歌海盆地构造演化主要受印支半岛早期的逃逸挤出构造和晚期的挤压-伸展构造系统影响(或控制),在此动力学驱动机制下,莺歌海盆地新生代以来的构造演化经历了3个阶段,即左旋走滑-伸展裂陷阶段、中下地壳韧性伸展-热沉降阶段和加速沉降阶段。     

莱州湾温带风暴潮预报研究

本文依据莱州湾羊角沟、夏营两站建国以来的风暴增水资料，对莱州湾建国后发生的风暴潮进行了统计分析，并探讨了温带风暴潮产生的物理机制，此外还对莱州湾温带风暴增水以及诱发增水的天气形势进行了分析分类。在此基础上建立了莱州湾温带风暴潮统计预报方法，并在作业预报中对模型进行了检验，取得较为理想的效果。     

A semi-analytical solution for random wave-induced soil response and seabed liquefaction in marine sediments

In this study, unlike most previous investigations for wave-induced soil response, a simple semi-analytical model for the random wave-induced soil response is established for an unsaturated seabed of finite thickness. Two different wave spectra, the B-M and JONSWAP spectra, are considered in the new model. The influence of random wave loading on the soil response is investigated by comparing with the corresponding representative regular wave results through a parametric study, which includes the effect of the degree of saturation, soil permeability, wave height, wave period and seabed thickness. The maximum liquefaction depth under the random waves is also examined. The difference on the soil response under the two random wave types, B-M and JONSWAP frequency spectra, is also discussed in the present work.     

Stress Sharing Behavior and Its Mechanism during Consolidation Process in Composite Ground Improved by Sand Compaction Piles with Low Replacement Area Ratio

In order to accurately design a sand compaction pile (SCP) with low replacement area ratio, it is important to understand the mechanical interaction between the sand pile and clay ground and its mechanism during consolidation process in composite ground. In this article, therefore, a series of numerical analyses on composite ground improved by SCP with low replacement area ratio were carried out. The applicability of numerical analyses, in which an elasto-viscoplastic consolidation finite element method was applied, were confirmed by comparing the results obtained from a series of laboratory model tests with the composite ground improved by SCP. Through the results of the numerical analyses, mechanical behavior of the sand pile and clay in composite ground during consolidation is elucidated, together with a stress sharing mechanism between sand pile and clay.     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。