高纯河豚毒素对蛙坐骨神经动作电位的影响

用电生理学方法观察了4种不同浓度的高纯河豚毒素(tetrodotoxin,TTX)对蛙离体坐骨神经动作电位的影响.实验结果表明:1μmol/dm3TTX在给药后7 min能显著抑制动作电位的上相幅度(P<0.05),但在给药后10 min才显著抑制动作电位的下相幅度(P<0.01);20μmol/dm3TTX在给药后3 min内能完全抑制动作电位的形成.1μmol/dm3TTX在给药后1~5min对动作电位传导速度的影响没有统计学意义,5μmol/dm3TTX在5min时可显著抑制传导速度(P<0.05),而10μmol/dm3TTX在2min时便显著抑制传导速度(P<0.05).实验结果提示高纯河豚毒素对蛙离体坐骨神经动作电位的影响存在剂量效应关系.     

波浪作用下岸坡和海底平衡条件的研究

提出波浪作用下岸坡和海底动态和静态平衡条件的数学模型。在已建立的推移质泥沙体积输沙率基本关系式的基础上,根据连续方程,计算出底坡、泥沙、波浪三要素在动态和静态平衡情况下的关系式,得出反映这种关系的底坡平衡函数曲线图。用实际资料对这一函数曲线进行了验证,并对实际资料相对模型的某些差异作出解释。     

Research on Characteristics of Density Current Under the Action of Waves

In this paper,the characteristics of density current under the action of waves are describedwith the help of flume experiment and theoretical analysis.The study shows that turbid water under the ac-tion of the waves can present three types of motion,i.e.significant stratification,fragile stratification andstrong mixing.The motion of turbid water presents significant stratification when(H/D)/△ρ/ρ~(1/2)≤4.5,generally this state is known as density current.The formulas of motionvelocity,thickness,and discharge of density current moving on horizontal bottom are derived by use of ba-sic equations such as momemtum equation,equation of energy conservation and continuity equation offluid.The time-average velocity and the thickness of density current under the action of waves have a rela-tionship with such parameters as relative density(△ρ/ρ),wave height(H),and water depth(D).Whenthese parameters are determined,the time-average thickness and motion velocity of density current are al-so determined.The relat     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

大民屯凹陷地层水水文地质特征与油气聚集关系

对大民屯凹陷前第三系潜山、下第三系沙河街组地层水化学场研究发现，本区油田水总矿化度及二价阳离子浓度偏低，地层水总矿化度具有明显的垂向分带性，水体主要为陆相成因并受地表水渗入的影响较大，变质程度高，油田水的演化与盐类的溶解有关。该区地层水的流动受断裂和沉积砂体的控制，在水头压力、浮力动力场控制下其流动样式和分布规律反映了凹陷内油气的运聚规律，可为本区自生自储、新生古储式油气藏的判别提供有利证据。     

Three-dimensional numerical simulation of obfique wave action on vertical walls

A three-dimensional numerical model based on the potential theory was developed to study the oblique wave action on vertical walls. A source term inside the domain was used to generate incident waves and outgoing waves were dissipated by sponge layers and transmitted by radiation boundaries. The finite difference method was used to solve the governing equations and boundary conditions in the regular transformed domain in σ-coordinate. Satisfactory agreements between the numerical predictions and experimental results of wave force were obtained. It is concluded that the maximum wave force acting on the vertical walls is induced by the obliquely incident waves rather than the normally incident waves.     

莱西市水资源管理系统的人机互动功能

本文结合莱西市水资源管理的基本特性,采用人机交互管理方式,成功地运用地理信息系统(GIS),实现了界面良好的莱西市水资源信息系统的各种功能,为规范水资源业务管理的程序、开展地区水资源管理信息系统化建设,提供了有力的技术支持。     

Investigation of the hydrate reservoir production under different depressurization modes

Abstract

Large reserves of natural gas hydrates exist, and the depressurization method has the greatest potential for gas hydrate reservoir recovery. Currently, the most commonly adopted depressurization simulation method is a constant bottom-hole pressure production scheme. This study proposes a new depressurization mode with decreasing bottom-hole pressure. The production characteristic was numerically investigated using this method. The results show the following: (1) As the depressurization exponent (n) decreases, the development effect improves, and production indexes including cumulative gas production/dissociation and gas-water ratio increase. However, the reservoir energy consumption is higher and the hydrate reformation is more severe. (2) Compared to the proposed depressurization mode, the hydrate production index of the constant bottom-hole pressure production (n?=?0) is better. However, the hydrate reservoir energy consumption is higher and the hydrate reformation is more severe using constant bottom-hole pressure production. (3) To achieve a balance between production and reservoir energy consumption during depressurization production, the bottom-hole pressure should be controlled by selecting a suitable depressurization exponent between n_min and n_max, which can be determined through numerical simulations.     

浙江省海岸侵蚀及防治概述

浙江海岸侵蚀现象普遍存在。基岩海岸海蚀地貌发育,因其组成物质抗冲蚀能力强,岸线后退不明显;砂砾质海岸普遍发生侵蚀,尤其是无计划的人工挖沙,造成沙滩减小或消失;淤泥质海岸大多处于缓慢的淤涨状态,但由于自然条件的改变和人为作用的影响,某些岸段发生侵蚀,特别是受到台风暴潮的影响,岸线在短时间内出现大规模后退和滩面下蚀。侵蚀岸段主要见于杭州湾北岸澉浦至金丝娘桥岸段,杭州湾南岸临山至西三岸段及瓯江口北岸盘石至黄华岸段。淤泥质海岸后缘为滨海平原,组成物质为粘土质粉砂,抗冲蚀能力弱,为防止和减轻海岸侵蚀,沿岸建造各类海岸工程(海塘、丁坝、导堤等),提高防潮抗浪能力,在朝滩种植大米草,互花米草,消浪促淤明显。另外,在海岸开发活动中,应加强海岸侵蚀监测和综合管理。     

运用德尔菲调查—灰色统计法确立水库鱼产力综合评价中的指标权重体系

本文运用德尔菲方法对水库鱼产力综合评价中指标权重的合理分配问题作了专家调查,并采用灰色统计法对调查结果进行归纳处理,从而确立了一个水库鱼产力影响因素诸层次各方面的评价指标权重体系,可供今后的评价工作参考使用。