The annual cycle of Synechococcus (cyanobacteria) in the northern Levantine Basin shelf waters (Eastern Mediterranean)

Abundance of picoplanktonic chroococcoid marine cyanobacteria Synechococcus was monitored weekly over the year 1998 in shallow coastal waters of the northern Levantine Basin. The ambient physical, chemical and biological variables (temperature, salinity, Secchi disk depth, total suspended sediment, nitrate, phosphate, Chl a and phytoplankton) were also measured. Synechococcus was found to be more abundant during summer and early autumn and less during winter and early spring. At the surface and 15 m depth, cell concentrations were in the range 6.4 × 10³–1.5 × 10⁵ and 3.2 × 10³–1.6 × 10⁵ cells·ml⁻¹, respectively. Based on the Pearson product–moment correlation analysis, a highly significant correlation between Synechococcus abundance and ambient temperature was observed (n = 40, r = 0.558, P < 0.01). As Synechococcus forms blooms that usually do not last more than a week, the short time‐scale survey achieved in this study was appropriate to reveal its abundance dynamics. Several factors such as rapid changes in nutrient concentration (especially nitrate), phytoplankton, light availability, temperature, salinity, freshwater input and vertical mixing played a relevant role on the abundance of Synechococcus over the year in the highly dynamic shallow coastal waters of the Levantine Basin.     

薛家岛湾沉积动力学特征及海港开发研究

于１９９０年秋对胶州湾内的薛家岛湾进行海洋水动力条件及积动力学特征,泥沙运动规律研究,为开发建设港口提供科学依据。结果表明,湾内深大于１ｍ的海底泥沙发生“全面移动”的时间,一年内仅有１－２ｄ,其余处于稳定状态或“表面移动”状态。湾内泥沙来源很少,预计建港后,港池和航道年平均回淤量分别小于１６ｃｍ,１０ｃｍ对于开发中小型港口十分有利。     

二(甲基环戊二烯)钐氯化物合成和晶体结构研究

作者以 Sm Cl3 与 (CH3 Cp) Na反应分离得到了三价稀土有机配合物 [(CH3 Cp) 2 Sm Cl·THF]2 的单晶 ,X-射线四圆衍射测定 ,该配合物属正交晶系 ,Pbna空间群 ,晶胞参数 a=9.6 6 2 (2 ) ,b=16 .4 76 (9) ,c=2 0 .582 (9) ;α=β=γ=90°,Z=4。并分析比较 [(CH3 Cp) 2 Sm Cl· THF]2 与其他三价稀土一氯化物的结构特点     

莺歌海盆地形成与演化的动力学机制

莺歌海盆地位于印支半岛与南海北部大陆边缘交接区,复杂的地质构造背景使其形成演化的动力学机制成为国内外的研究焦点。从区域动力学演化的角度,系统分析了影响莺歌海盆地发育的印支地块构造演化特征,认为莺歌海盆地构造演化主要受印支半岛早期的逃逸挤出构造和晚期的挤压-伸展构造系统影响(或控制),在此动力学驱动机制下,莺歌海盆地新生代以来的构造演化经历了3个阶段,即左旋走滑-伸展裂陷阶段、中下地壳韧性伸展-热沉降阶段和加速沉降阶段。     

Population dynamics of Callichirus major (Say, 1818) (Crustacea, Thalassinidea) on a beach in northeastern Brazil

We describe the structure, reproductive cycle, fecundity, growth, and mortality of a harvested population of the ghost shrimp Callichirus major. Samples were collected at monthly intervals from September 1999 to October 2000 on an urban sandy beach (08°11′S 34°55′W) in northeastern Brazil. During this period the sex ratio did not differ significantly from 1:1 (0.98 M: 1 F). Minimum and maximum sizes of the Dorsal Oval were 2.59 and 12.19 mm for males and 4.46 and 12.62 mm for females, respectively. Ovigerous females were found throughout the period, except between August and September 2000. Maximum lifespan was estimated as 3.3 and 3.4 years for females and males, respectively. This northeastern population differed from others previously studied in southern and southeastern Brazil, in regard to sex ratio, maximum attained size, maturation size, period and duration of the reproductive cycle, and fecundity. We interpret these regional differences as evidence for over-fishing at the study site, and suggest that large-scale management plans for callianassid populations should use regional population parameters.     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。