Estradiol and estriol suppress CYP1A expression in rainbow trout primary hepatocytes

Hepatic levels of the pollutant inducible enzyme, CYP1A, are strongly suppressed in spawning female fish, a phenomenon attributed to high plasma levels of the female sex steroid hormone, estradiol. To evaluate the contribution of estrogen metabolites to estradiol-mediated CYP1A regulation, we treated primary hepatocytes isolated from juvenile rainbow trout (Oncorhynchus mykiss) with vehicle, 17beta-estradiol, or the estrogen metabolite, estriol, alone and in combination with each other and with the potent CYP1A inducer, benzo[a]pyrene (B[a]P). We found dose-dependent suppression of B[a]P-induced CYP1A activity by both steroids relative to controls. At 10(-7) M doses, estradiol and estriol suppressed B[a]P-induced CYP1A activity by 3- and 2-fold, respectively. Although not statistically significant, mean basal CYP1A activity levels were 15- and 13-fold lower in estradiol and estriol treated hepatocytes, respectively, relative to vehicle treated controls. Combining doses of estradiol and estriol failed to produce synergistic suppression of either basal or B[a]P-induced CYP1A activity relative to treatment with either steroid alone. The observed suppression is well below the often strong suppression observed in spawning female fish. We conclude that factors in addition to estradiol and estriol are likely involved in producing sexual dimorphism in CYP1A expression observed in spawning fish.     

Oceanographic influences on seabirds and cetaceans of the eastern tropical Pacific: A review

This paper is part of a comprehensive review of the oceanography of the eastern tropical Pacific, the oceanic region centered on the eastern Pacific warm pool, but also including the equatorial cold tongue and equatorial current system, and summarizes what is known about oceanographic influences on seabirds and cetaceans there. The eastern tropical Pacific supports on the order of 50 species of seabirds and 30 species of cetaceans as regular residents; these include four endemic species, the world’s largest populations for several others, three endemic sub-species, and a multi-species community that is relatively unique to this ecosystem. Three of the meso-scale physical features of the region are particularly significant to seabirds and cetaceans: the Costa Rica Dome for blue whales and short-beaked common dolphins, the Equatorial Front for planktivorous seabirds, and the countercurrent thermocline ridge for flocking seabirds that associate with mixed-species schools of spotted and spinner dolphins and yellowfin tuna. A few qualitative studies of meso- to macro-scale distribution patterns have indicated that some seabirds and cetaceans have species-specific preferences for surface currents. More common are associations with distinct water masses; these relationships have been quantified for a number of species using several different analytical methods. The mechanisms underlying tropical species–habitat relationships are not well understood, in contrast to a number of higher-latitude systems. This may be due to the fact that physical variables have been used as proxies for prey abundance and distribution in species–habitat research in the eastern tropical Pacific.Though seasonal and interannual patterns tend to be complex, species–habitat relationships appear to remain relatively stable over time, and distribution patterns co-vary with patterns of preferred habitat for a number of species. The interactions between seasonal and interannual variation in oceanographic conditions with seasonal patterns in the biology of seabirds and cetaceans may account for some of the complexity in species–habitat relationship patterns.Little work has been done to investigate effects of El Niño-Southern Oscillation cycles on cetaceans, and results of the few studies focusing on oceanic seabirds are complex and not easy to interpret. Although much has been made of the detrimental effects of El Niño events on apex predators, more research is needed to understand the magnitude, and even direction, of these effects on seabirds and cetaceans in space and time.     

溴素的有机化学──Ⅴ.溴代脂肪酸—2,3,5,6—四溴—1,4—苯二酯的合成

以1，4—苯二酚和不同的短链脂肪酸为基本原料，经溴代、加成、形成酰卤和酰化等反应，合成了六种新的溴化脂肪酸—2，3，5，6—四溴—1，4—苯二酯。通过对产物的碳、氢、溴等元素的定量分析，以及红外吸收光谱和氢核磁共振谱的研究，验证了化合物的结构。     

Characteristic analysis on oxygen isotopic tracer in the East China Sea and waters to east of the Ryūkyū-guntō

Samples of O isotopic tracer were mlleMed at Sections P₃,P₂₅,P_cM-t/2-E and P_CM-1/2.w in both the Fast China Sea and the area to the east of the Ryūkyū-gunto during October-November,1991.Analytical results of the δ¹⁸O are as follows: (1) In the Kuroshio area,the δ¹⁸O isolines are almost parallel to the 200 m isobath.The value of δ¹⁸O is negative and reaches minimum mt the main axis of the Kuroshio,and increases on both sides.(2) In the Taiwan Warm Current (TWC) area there is a high δ¹⁸O tongue extending to the northeast.(3) In the area near the coast,the distribution of δ¹⁸O isoline shows that the Changjiang River runoff diffuses seaward and the land-ocean isotopic effect from the nearshore to the offshore.(4) The values of δ¹⁸O are from -1.0×10^-3 to -0.5×10^-3 in the shelf.(5) There is a low mre of δ¹⁸O value(<-1.6×10^-3) at the 600 m layer in the Kuroshio area,which is quite in accord with the existence of a low salinity mre (S G 34.30) between the 600 and 800 m layers in the same area.Finally,the mrrelations of the δ¹⁸O with the salinity and temperature,the upwelling and so on are discussed.     

0421号热带风暴"海马"登陆前后环境场对其移向和强度影响的分析

0421号热带风暴“海马(Haima)”于2004年9月13日12:00在浙江省温州市沿海登陆,登陆后迅速减弱为热带低压,20:00在浙江境内消失.本研究采用物理量诊断分析法,探讨该热带风暴登陆前后涡度场、湿焓场变化对其移向和强度的影响.结果表明,该热带风暴登陆后,涡度(ξ)明显减弱.涡度局地变化(ξ/t)值分布显示,风暴移动方向的后方,涡度减弱的趋势比前方涡度增大的趋势更剧烈;风暴有向其外围(ξ/t)正值中心(即涡度增幅最大)移动的趋势.该热带风暴登陆前、后,湿焓都增大,但登陆后湿焓增大趋势已大大减弱;风暴有向湿焓局地变化(E/t)正值中心移动的趋势,即向能量增强最大的方向移动.     

西太平洋暖池变异及其对西太平洋次表层海温场的影响

应用热带太平洋上层XBT温度资料,分析研究了西太平洋暖池区(0°～16°N,125°～145°E)上层海洋的变化特征以及与西太平洋次表层海温场之间的关系.研究表明,西太平洋暖池区的垂向温度存在显著的年际变化,尤其在次表层(120～200m)的变化最为明显.西太平洋暖池区的次表层冷暖信号明显早于西太平洋次表层的海温异常.分析发现,西太平洋暖池区的海温异常是导致整个西太平洋次表层海温场变异的关键区,当西太平洋暖池区的次表层冷暖信号加强时,3～4个月后西太平洋海温场出现大范围的冷暖异常.     

北部湾三维潮流场数值研究(英文)

本文对北部湾三维潮波进行了数值研究,并将所得结果与现有观测资料作了比较。通过比较发现两者相当一致。文中还绘制了M_2和K_1分潮的同潮图,并对其作了讨论。可以断定,北部湾的日潮优势是由日潮共振所引起的。M_2和K_1分潮流的水平分布表明,强流区位于它们各自的蜕化无潮点附近。还讨论了分潮流的铅直结构,可以看出这种结构十分接近实际分潮流场的特征。     

烟单14号玉米产量与土壤养分关系的研究

根据大量田间试验和调查资料分析,作者提出烟单14号玉米生长过程中,小喇叭口期土壤中全氮、大喇叭口期土壤中速效磷的含量与产量相关密切。并据此建立了产量及构成三因素与土壤养分间的最优相关模型。     

南海及周边部分地区特提斯构造遗迹:问题与思考

对全球二叠纪－三叠纪古气候特征的研究表明，东特提斯地区晚三叠世古气候标志具有带状分布的特征。北巴拉望地块卡拉棉群岛科龙岛的晚三叠世沉积中发育反映较干燥古气候特征的鲕状灰岩，因此在古气候特征方面，北巴拉望地块晚三叠世地层不能与华南和印支地块同期地层对比，而应该与印度地块北缘喜马拉雅地区（向西）和琉球群岛（向东）对比。根据该古气候分析，北巴拉望地块在晚三叠世时应该位于南部亚热带较干燥气候带内，其晚三叠世的古地理位置比印支地块更靠南。对南海及南海周边部分地特提斯构造遗迹的研究，将有助于深入了解南海北部陆缘区相关构造带的性质及正确恢复南海扩张之前该区的地质发展历史。南海北部陆缘区也是研究解决特提斯构造向东延伸问题以及特提斯构造－太平洋构造时空转化问题的关键地区。     

潮汐沉积率与沉积间断

在浙北奥陶系文昌组和长江三角洲开敞型淤泥质海岸非潮道潮汐纹层研究的基础上,得出与国外同类研究相近的沉积率。现代海岸进积速度和潮坪沉积的观察及测试证明,上述沉积率是难以置信的。现代潮坪观测表明,潮汐纹层在形成过程中即包含着改造,所保留的纹层占应形成数的不到１０％,其余９０％以上被侵蚀。小型层序是风暴和平静天气的产物,为风暴层序,与大小潮周期无关。其地层中保留的数量不到应生成数的１０％,其余９０％被改造。小型层序被侵蚀,其中的纹层随之消失。致使潮坪层序中保存的纹层数仅为应形成数的０．２％。被改造的纹层和单层留下的仅是侵蚀面,即小间断。在进行潮汐沉积高分辨率的研究时应充分重视沉积间断的作用