一次西南印度洋热带气旋过程发展机制的数值研究

本文利用尽可能多的观测资料和WRF-3.4.1模式(Weather Research and Forecasting Model)对2012年1月19日至28日发生在西南印度洋上空的1次强热带气旋进行了研究,并分析其时空结构和发展机制。对该热带气旋的移动路径、强度及内部结构的数值模拟结果与实际符合较好。分析表明,感热和凝结潜热贯串于热带气旋发展的整个过程,其中感热对气旋发展的影响较弱,凝结潜热是气旋发展的主要能量来源,CISK机制可解释该热带气旋的发展过程。     

水生入侵植物对常见水华的抑藻效应及其影响机理

为促使水生入侵植物的资源化利用以减少其对环境的危害,本文选取我国3种常见水生入侵植物,即水浮莲(Pistia stratiotes)、凤眼莲(Eichhornia crassipes)、空心莲子草(Alternanthera philoxeroides)作为研究对象,研究不同的植物化感作用方式(植物种植水抑藻、植物粗提物抑藻)对蛋白核小球藻(Chlorella pyrenoidosa)、梅尼小环藻(Cyclotella meneghiniana)、铜绿微囊藻(Microcystis aeruginosa)这3种常见水华微藻生长的抑制作用差异及其影响机理。结果表明,3种植物的种植水和粗提物均对不同微藻表现出选择性抑制作用,且种植水的抑藻效果总体强于粗提物。其中以空心莲子草种植水对铜绿微囊藻的抑制作用最强,共培养第7天藻细胞光密度OD750值下降78.19%,叶绿素a(chl a)含量下降96.61%。铜绿微囊藻在空心莲子草种植水影响下,藻细胞的呼吸速率先升高后降低,光合速率逐渐降低,超氧化物歧化酶(superoxide dismutase,SOD)、过氧化物酶(peroxidase,POD)、过氧化氢酶(catalase,CAT)等抗氧化酶的活性,以及蛋白质和膜脂过氧化产物丙二醛(malondialdehyde,MDA)的含量均呈现先升高后降低的趋势,由此可知铜绿微囊藻在共培养过程中受到了明显的胁迫和伤害。而在共培养第11天,实验组的胞外藻毒素含量较对照组仅增加8.69%,差异不显著(P0.05),说明空心莲子草种植水在有效抑制铜绿微囊藻生长的同时不会促进藻毒素的释放,具有较好的生态安全性。     

Large aperture seismic imaging at a convergent margin: Techniques and results from the Costa Rica seismogenic zone

In March and April 1995 a cooperative German, Costa Rican, and United States research team recorded onshore-offshore seismic data sets along the Pacific margin of Costa Rica using the R/V Ewing. Off the Nicoya Peninsula we used a linear array of ocean bottom seismometers and hydrophones (OBS/H) with onshore seismometers extending across much of the isthmus. In the central area we deployed an OBS/H areal array consisting of 30 instruments over a 9 km by 35-km area and had land stations on the Nicoya Peninsula adjacent to this marine array and also extending northeast on the main Costa Rican landmass. Our goal in these experiments was to determine the crustal velocity structure along different portions of this convergent margin and to use the dense instrument deployments to create migrated reflection images of the plate boundary zone and the subducting Cocos Plate. Our specific goal in the central area was to determine whether a subducted seamount is present at the location of the 1990, M 7 earthquake off the Nicoya Peninsula and can thus be linked to its nucleation. Subsequently we have processed the data to improve reflection signals, used the data to calculate crustal velocity models, and developed several wide-aperture migration techniques, based on a Kirchhoff algorithm, to produce reflection images. Along the northern transect we used the ocean bottom data to construct a detailed crustal velocity model, but reflections from the plate boundary and top and bottom of the subducting Cocos plate are difficult to identify and have so far produced poor images. In contrast, the land stations along this same transect recorded clear reflections from the top of the subducting plate or plate boundary, within the seismogenic zone, and we have constructed a clear image from this reflector beneath the Nicoya shelf. Data from the 3-D seismic experiment suffer from high-amplitude, coherent noise (arrivals other than reflections), and we have tried many techniques to enhance the signal to noise ratio of reflected arrivals. Due to the noise, an apparent lack of strong reflections from the plate boundary zone, and probable structural complexity, the resulting 3-D images only poorly resolve the top of the subducting Cocos Plate. The images are not able to provide compelling evidence of whether there is a subducting seamount at the 1990 earthquake hypocenter. Our results do show that OBS surveys are capable of creating images of the plate boundary zone and the subducting plate well into the seismogenic zone if coherent reflections are recorded at 1.8 km instrument spacing (2-D) and 5 km inline by 1 km crossline spacing for 3-D acquisition. However, due to typical high amplitude coherent noise, imaging results may be poorer than expected, especially in unfavorable geologic settings such as our 3-D survey area. More effective noise reduction in acquisition, possibly with the use of vertical hydrophone arrays, and in processing, with advanced multiple removal and possibly depth filtering, is required to achieve the desired detailed images of the seismogenic plate boundary zone.     

基于网络药理学和分子对接技术探究柯里拉京治疗卵巢癌的关键靶点及分子机制

目的：采用网络药理学和分子对接技术相结合的方法探究柯里拉京（Cor）治疗卵巢癌的关键作用靶点和分子机制。方法：利用PharmMapper、TargetNet及Swiss Target Prediction在线工具预测Cor的作用靶点,通过OMIM、TTD、CTD、DisGenet、PharmGKB及MalaCards数据库获取卵巢癌相关的疾病靶点,并将药物靶点与疾病靶点取交集得到Cor治疗卵巢癌的预测靶点。借助STRING数据库、Cytoscape 软件构建蛋白质-蛋白质相互作用（PPI）网络,并采用CentiScape插件筛选出PPI网络中的核心靶点。运用GEPIA和Kaplan-Meier Plotter在线平台分别对这些核心靶点进行基因表达差异分析和生存分析,以明确Cor治疗卵巢癌的关键靶点。利用DAVID数据库进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析。运用Autodock Vina软件进行正向分子对接,预测关键靶点和Cor之间的结合活性。结果：Cor治疗卵巢癌的预测作用靶点共24个,其中RAC-α丝氨酸/苏氨酸蛋白激酶(AKT1)、表皮生长因子受体(EGFR)、雌激素受体1(ESR1)、原癌基因酪氨酸蛋白激酶(SRC)是Cor治疗卵巢癌的关键靶点,主要涉及血管内皮生长因子(VEGF)信号通路、缺氧诱导因子-1(HIF-1)信号通路及叉头样转录因子(FoxO)信号通路,可能通过调控细胞凋亡、细胞增殖、血管内皮细胞迁移等生物过程而发挥治疗卵巢癌的作用。分子对接结果显示,Cor与预测靶点之间具有较好的亲和力,表明通过网络药理学预测作用靶点的方法具有良好的可靠性。结论：Cor是通过多靶点、多通路的协同作用来干预多个生物过程,从而发挥其抗卵巢癌疗效,为进一步研究其治疗卵巢癌的分子机制提供了新的线索。     

厄尔尼诺的发生与行星运动

厄尔尼诺(El Ni(?)o)现象是海-气耦合系统异常变化的表现,其起因可能不是唯一的,行星运动对地球运动的影响可能会导致El Ni(?)o的发生。根据4个半世纪内El Ni(?)o发生的历史资料,分析其发生和行星运动的关系,得出的结论是:木星赤纬的变化和火星大冲与El Ni(?)o。的发生有显著的关系,表明这2颗行星的运动可能影响El Ni(?)o的发生。文中还根据分析结桌和El Ni(?)o混沌机制的观点,探讨了行星运动对海-气系统变化的影响机制。     

珠江口盆地东沙隆起的沉降史及其动力机制

根据东沙隆起及其周围钻井资料的一维构造沉降对比分析,结合前人在基底、盖层及断裂等方面的研究,将东沙隆起地区的构造演化分为5个阶段:自垩纪挤压阶段、古新世-早渐新世伸展断陷阶段、早渐新世末期抬升剥蚀阶段、晚渐新世-中新世快速的裂后沉降阶段、晚中新世以来断块升降阶段.认为下地壳高速层是促使早渐新世末期抬升剥蚀的重要因素,而...     

Biochemical Mechanism of the Eutrophication and Its Prevention—the Deep Treatment of Waste Water and Its Denitrification and Dephosphorization

Biochemical mechanism of forming the red tide is discussed in this paper.The existence of a large number of nitrates and phosphates in the eutrophic water is the prerequisite of explosive increase of algae and the forming of red tide.Reduction of eutrophication is an important approach to preventing the red tide.The method of deep treatment of the waste water and its denitrification and dephosphorization are introduced,and a new opinion on the red tide formation and fundamental prevention is put forward.     

华南花岗岩型铀矿床成矿机理研究进展

本文介绍了华南花岗岩型铀矿床地质特征,系统总结了前人对其成矿热液来源、物质来源,铀的迁移沉淀机制、碱交代及花岗岩与成矿的关系等方面的研究成果。指出铀源体中的晶质铀矿及富铀矿物在深部相对还原的环境中被氧化而进入成矿热液中起主要作用的可能是大量幔源F和放射性衰变诱发产生的氧及碱交代溶蚀作用,热液中的大部分U6 主要被S2-和Fe2 等还原剂在浅部相对氧化的环境中还原成矿;给出了一种较简易的物质来源定量方法和铀成矿模式。     

基于“情景-应对”的矿井水灾事故应急决策机制

为解决矿井水灾事故应急快速反应、高效决策的现场需求,针对矿井水灾事故的不确定性、复杂性和紧迫性等特点,运用多案例分析法,解析了11起典型矿井水灾事故,提出了判别“情景”和事故“情景”两个关键概念,定义了集合{突水水源,突水通道,采掘方式,出水量,淹没范围,生存空间}为矿井水灾事故的情景,并运用AHP分析法计算了6个情景要素各自的权重。确立了“情景-应对”应用在矿井水灾应急决策领域的实现途径,详细阐述了构建情景库、案例库、对策库的方法以及“情景-应对”型矿井水灾应急决策方案的生成过程,并提出了以“黄金72小时” “8天8夜”为时间节点的多阶段矿井水灾事故应急决策机制,案例推演应用表明,该应急决策机制不仅规范了事故应急流程,而且实现了精准、快速、高效的目标。