基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

东亚温带气旋及其长期预报（二）：预报应用分析

本文以赤道东太平洋海温作为主导因子，分析其与东亚温带气旋的关系。得出：高海温多气旋，低海温少气旋的对应关系较为明显。并进一步对不符合这种主要关系的年份从环流型。下垫面海温等作了分类鉴别分析。     

崎岖列岛附近海域环境质量现状与分析

根据 2 0 0 1年 2月和 7月对崎岖列岛附近海域的水质和底质表层沉积物调查结果 ,采用环境质量单项评价标准指数法 ,对该海域环境质量现状进行了评价与分析。结果表明 :(1 )该海域水质的 p H值、溶解氧和石油类等环境因子基本符合一类海水水质标准 ,化学需氧量、活性磷酸盐和无机氮浓度则超标严重 ,该海域水质已处于严重富营养化状态 (夏季比冬季富营养化程度略低 ) ;(2 )该海域底质表层沉积物中除部分站位的重金属 Cu、 Zn含量超标外 ,有机质、石油类和重金属 Pb、 Cd、 Hg的含量均未超标 ,底质环境状况尚好     

一种新的波浪变形三维数值模式──0-1混合型边界元

为提高边界元法模拟三维波场波浪变形的数值计算精度,借鉴常数元和线性元剖分方式、波势函数及波势函数法向导数对单元节点设定的各自适应性,提出了一种新的单元剖分模式──0-1混合型边界元,以控制和减缓由于计算误差累计而造成的波浪数值计算上的“横向振动”,借此结合边界元法的分区模式可实现较大范围的波场线性波浪变形计算,并为时域内的波浪非线性变形计算提供时间步长的数值保证.     

南极冰退与深圳湾北岸海平面变化的地质记录

南极冰层的冰量为２４．５×１０６ｋｍ３，占地球总冰量的９０％以上，南极冰川进退控制着全球海平面变化和气候波动。酉部南极乔治王岛第四纪冰碛与湖积剖面记录了近１２０００ａ来南极曾于距今１１０００ａ，９０００ａ和６１００ａ出现过３次快速的冰消过程，近６０００ａ来是一小幅度冷暖交替的气候波动过程。深圳湾北岸潮间带堆积是在近６０００ａ以来发育的，堆积物的环境记录表明，海平面呈周期性升降变化，波动周期平均为６７０ａ，低海面时期发生于距今５５００—４９００ａ，３９００—３６００ａ，２４００—２２００ａ和１３００—１２００ａ。相邻低海面间则是海面上升时期，每一升降周期的海平面变化幅度为８０ｃｍ左右，近１００ａ的现代增温，海平面处于上升阶段，上升速率为２—３ｍｍ·ａ（－１）。     

一种新型测向传感器——磁通门罗盘

本文对磁通门罗盘的基本工作原理、实验线路以及主要技术指标和一些测量数据作简要介绍,最后对仪器的误差进行简单分析并提出一些减小误差的改进措施。     

渤海三维海洋温度和海流数值预报

"十·五"期间,我国开展了三维海洋温度和海流数值预报的业务化研究工作.经过3年的努力,渤海三维海洋温度和海流数值预报系统研制完成,并于2003年10月,开始试预报.本文对该预报系统以及运行情况进行了介绍,并分析了所存在的问题和发展方向.     

A New Pursuit Mode of Nonlinear Wave Surface

The numerical mode of nonlinear wave transformation based on both the Laplace equation for water field and the Bemoulli equation for water surface is a kind of time-domain boundary problem with initial conditions. And the basis for establishing the numerical mode of nonlinear wave in time domain is to trace the position of wave free surface and to calculale the instantaneous surface height and surface potential function. This paper firstly utilizes the ‘0-1‘ combined BEM to separate the boundary by means of discretization of Green‘ s integral equation based on the Laplace equation, then separates the free surface of wave with FEM and derives the FEM equation of wave surface that satisfies the nonlinear boundary conditions. By jointly solving the above BEM and FEM equations, the wave potential and surface height could be obtained with iteration in time domain. Thus a new kind of nonlinear numerical mode is established for calculating wave transformation. The wave test in the numerical wave tank shows that the numerical simulation with this mode is of high accuracy.     

基于雷达海冰图像互相关的冰漂流场测量

我国的渤海和黄海北部在每年冬季都出现不同程度的冰情,它直接影响结冰海区的石油平台、船舶以及港口等设施的正常作业,对海冰的观测与预报随着上述海区的开发利用越发显得重要,利用航海雷达连续准确地跟踪海冰漂移运动轨迹,是当今观测、调查、研究冰漂流移动规律的有效方法之一,我国的科研人员利用雷达成像技术对渤海的冰情进行了长期的雷达海冰观测、研究,在由雷达海冰图像对海冰的物理特征的识别、分类以及冰漂流场测量方面取得了一些进展[1-4]。     

Late Quaternary Seasonal Sea-Ice History of the Northeastern Japan Sea

The Late Quaternary sea-ice history of the northeastern Japan Sea is discussed on the basis of the occurrence of dropstones and ice-rafted debris (IRD) in fine sediment cores. IRD was found in all strata except those from the Holocene and oxygen isotope stage 5.5. The largest expansion of sea ice was recognized at the last glacial maximum (LGM; oxygen isotope stage 2), when the southern margin of seasonal sea ice was probably located in the vicinity of the Matsumae Plateau. The margin might occasionally have expanded further southward to off the Oga Peninsula. Sea ice expanded southward from mid-stage 5 to the LGM in response to global cooling, but with much fluctuation. Sea ice remained during deglaciation until around 10 ka, but after 10 ka it retreated northward rapidly in response to global warming and changes in surface water conditions. Greater fluctuations in IRD were found in core GH95-1208 collected from off Rumoi, Hokkaido, Japan. More IRD was found in sediments from late stage 3, late stage 5, and early stage 6. The fluctuations were not concordant with global climate changes (based on the standard oxygen isotope curve), and may have been controlled by regional climate factors such as the strength of the winter monsoon, which is related in turn to high-latitude atmospheric circulation. This revised version was published online in July 2006 with corrections to the Cover Date.