Generalized strain probing of constitutive models

Advanced material constitutive models are used to describe complex soil behaviour. These models are often used in the solution of boundary value problems under general loading conditions. Users and developers of constitutive models need to methodically investigate the represented soil response under a wide range of loading conditions. This paper presents a systematic procedure for probing constitutive models. A general incremental strain probe, 6D hyperspherical strain probe (HSP), is introduced to examine rate‐independent model response under all possible strain loading conditions. Two special cases of HSP, the true triaxial strain probe (TTSP) and the plane‐strain strain probe (PSSP), are used to generate 3‐D objects that represent model stress response to probing. The TTSP, PSSP and general HSP procedures are demonstrated using elasto‐plastic models. The objects resulting from the probing procedure readily highlight important model characteristics including anisotropy, yielding, hardening, softening and failure. The PSSP procedure is applied to a Neural Network (NN) based constitutive model. It shows that this probing is especially useful in understanding NN constitutive models, which do not contain explicit functions for yield surface, hardening, or anisotropy. Copyright © 2004 John Wiley & Sons, Ltd.     

LabVIEW设计中压力传感器的RBF神经网络温度补偿

在石油平台注水压力监测系统设计中 ,采用LabVIEW虚拟仪器平台 ,嵌入逼近能力强和收敛速度快的RBF神经网络 ,以人工环境实验数据为样本进行训练 ,实现了压力传感器的智能网络温度补偿。结果显示 ,此方法能够在压力、温度变化较大的恶劣环境下 ,获得很高的补偿精度。     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

人工神经网络在岩体质量分级中的应用

结合四川省金沙江某水电站工程实例，应用BP人工神经网络方法建立3层BP网络模型，选取岩石单轴抗压强度等6个影响因素为输入变量，对坝基复杂岩体进行质量分级。通过机算机Visual C 语言编程实现神经网络模型，进行网络的学习和运算。以神经网络合理结构分析方法选取合理结构，确定合理隐层单元的数量，提高网络测试的精度。对测试结果的分析发现，经过优化的BP网络模型经多次学习后，测试精度提高，结果可靠，取得较好的实际应用效果。     

涡北河网区三维地震采集技术

涡北勘探区属于河网地带,难以进行正常的地震施工。为此,本文提出了一种以规则束状观测为基础和特殊观测系统相结合的数据采集方法。该方法适应了这种复杂的地表条件,获得了"空白区"的地震资料,为今后类似地表条件地区的三维地震勘探提供了经验。      

南海陆坡大型块体搬运体系的结构与识别特征

近年来的地质与地球物理调查发现,在大陆坡第四系中发育有大规模块体搬运体系(现今的块体搬运体系也称海底滑坡)。块体搬运体系是深水常见的一种沉积物搬运机制,主要包括滑动、滑塌和碎屑流等重力流过程及其沉积物。南海陆坡白云块体搬运体系面积逾10 000 km2,可划分为3个结构单元,即头部拉张区、体部滑移-挤压区和趾部挤压区。在地震剖面中,发育多种构造:正断层、杂乱反射、逆冲断层、挤压脊和褶皱等。块体搬运体系严重威胁深水设施安全,并可能诱发海啸,是海洋地质灾害之一。同时,块体搬运体系与海洋油气及天然气水合物关系密切,物源决定块体搬运体系的物性,泥质物源的块体搬运体系通常作为良好的油气盖层,砂质物源形成的块体搬运体系可以成为储层。     

CASS在平度市鑫汇金矿勘测中的应用

CASS在测量中得到广泛应用,特别是CASS配合Autolisp语言,还可以编写一些常用小程序,使测量计算和作图过程得到大量简化。地质坑道测量在矿山测绘中占有重要地位,可以将CASS与全站仪配合,在测量坑道过程中,进行坑道平面图绘制,指导井下开矿,提高工作效率。还可以利用CASS计算坑道挖掘土方量,这样便于与施工方进行工程量结算及处理井下越界开采纠纷问题。     

The Coral Triangle Initiative and regional exchanges: Strengthening capacity through a regional learning network

Natural resource management and conservation programs that promote building capacity and social learning among participants often lead to the formation of learning networks: a type of social network where learning is both a goal and potential outcome of the network. Through forming relationships and sharing information, participants in a learning network build social capital that can help a network achieve social and environmental goals. In this study, we explored social capital in a learning network that emerged through a large-scale marine governance effort, the Coral Triangle Initiative on Coral Reefs, Fisheries, and Food Security. Through a mixture of social network analysis and key informant interviews, we examined the major patterns of information exchange among individuals who had participated in regional learning exchanges; evaluated whether the network's structure resulted in information sharing; and considered implications for strengthening network sustainability, capacity building, and learning. We found that the Regional Exchange network fostered information sharing among participants across national and organizational boundaries. While the network had individuals who were more central to information sharing, the network structure was generally decentralized, indicating potential resilience to changes in leadership and membership. Participants stressed the importance of the knowledge and connections they had acquired through the learning network; however, they expressed doubts regarding its sustainability and stressed the need for a strong coordinating entity. Our findings suggest that conservation learning networks have the ability to bridge cultural divides and promote social learning; however, a strong network coordinator and continuing efforts to support information sharing and learning are crucial to the network's strength and sustainability. The tangible learning and capacity development outcomes cultivated through Regional Exchange network underscore the value of and need to invest in conservation networks that support peer-to-peer learning.     

基于移动网络的端到端密钥协商协议

虽然3G网络的安全机制扩展到核心网络,但是并没有实现端到端安全.基于自生成证书公钥密码体制,设计一种端到端密钥协商协议,只需要一个消息交换就可以建立安全的三方会话密钥.安全性分析结果表明:基于移动网络的端到端密钥协商协议能够解决密钥管理及第三方无举证窃听,与其他密钥协商协议相比,具有较好的安全性,为端到端加密在移动通信系统中的大规模应用提供基础.