Biodegradability of the Anti-tumour Agents 5-Fluorouracil,Cytarabine, and Gemcitabine: Impact of the Chemical Structure and Synergistic Toxicity with Hospital Effluent

Most anti-tumour agents are known to be carcinogenic, mutagenic, teratogenic, embryotoxic or fetotoxic. Only little is known about the environmental impact of pharmaceuticals. Unmetabolized active substances are excreted and will show up in municipal wastewater. Therefore, we examined the biodegradability of the widely used anti-tumour agent 5-fluorouracil (5-FU), also as an example for assessing the impact of hospital effluent on the biodegradation of a test compound. The biodegradability of the structurally similar anti-tumour agents cytarabine and gemcitabine was also examined. Test systems used were the closed bottle test (OECD 301 D) and the modified Zahn-Wellens test (OECD 302 B). 5-FU was not biodegradable in the closed bottle test (CBT) nor in the Zahn-Wellens test (ZWT). At the highest concentration of 5-FU, with hospital effluent an inhibition of the degradation of substances present in hospital effluent was observed, probably as a result of a synergistic effect by 5-FU with antibiotics present in hospital sewage. Gemcitabine was biodegraded 42% in the CBT. The prolongation of the test period to 40 days only improved the result to 45%. In the ZWT, the biodegradation of gemcitabine was 50%. Cytarabine was partially biodegraded in the CBT (50%), but only after an adaptation period of 20 days. After a test prolongation to 40 days, the degree of biodegradation was 80%. In the ZWT, the biodegradability was > 95% after only a few days.     

Kinetics of the Gas-Phase Reactions of OH Radicals, NO3 Radicals and O3 with Three C7-Carbonyls Formed From The Atmospheric Reactions of Myrcene, Ocimene and Terpinolene

Rate constants for the gas-phase reactions of OH radicals, NO₃ radicals and O₃ with the C₇-carbonyl compounds 4-methylenehex-5-enal [CH₂=CHC(=CH₂)CH₂CH₂CHO], (3Z)- and (3E)-4-methylhexa-3,5-dienal [CH₂=CHC(CH₃)=CHCH₂CHO] and 4-methylcyclohex-3-en-1-one, which are products of the atmospheric degradations of myrcene, Z- and E-ocimene and terpinolene, respectively, have been measured at 296 ± 2 K and atmospheric pressure of air using relative rate methods. The rate constants obtained (in cm³ molecule^–1 s^–1 units) were: for 4-methylenehex-5-enal, (1.55 ± 0.15) × 10^–10, (4.75 ± 0.35) × 10^–13 and (1.46 ± 0.12) × 10^–17 for the OH radical, NO₃ radical and O₃ reactions, respectively; for (3Z)-4-methylhexa-3,5-dienal: (1.61 ± 0.35) × 10^–10, (2.17 ± 0.30) × 10^–12, and (4.13 ± 0.81) × 10^–17 for the OH radical, NO₃ radical and O₃ reactions, respectively; for (3E)-4-methylhexa-3,5-dienal: (2.52 ± 0.65) × 10^–10, (1.75 ± 0.27) × 10^–12, and (5.36 ± 0.28) × 10^–17 for the OH radical, NO₃ radical and O₃ reactions, respectively; and for 4-methylcyclohex-3-en-1-one: (1.10 ± 0.19) × 10^–10, (1.81 ± 0.35) × 10^–12, and (6.98 ± 0.40) × 10^–17 for the OH radical, NO₃ radical and O₃ reactions, respectively. These carbonyl compounds are all reactive in the troposphere, with daytime reaction with the OH radical and nighttime reaction with the NO₃ radical being predicted to dominate as loss processes and with estimated lifetimes of about an hour or less.     

地脉动测试技术若干问题的讨论

讨论了地脉动的测试技术以及测试工作中应该重视而且容易被忽视的问题 ,并就地脉动幅值域和频率域特性参数提出不同的看法     

应用GMS5多通道云图估计降水技术的研究

对近两年来5～8月中国东部地区120多个测站雨量观测资料和对应4400多幅GMS-5四个通道云图的研究发现：红外亮温的时间、空间变率、红外和水汽通道亮温差等云图衍生资料对消除卷云，弥补夜间缺少可见光云图的不足起到明显作用。从而，应用双判据双重MOS多元回归法建立四通道云图因子、衍生因子与降水量之间的回归方程，进行6小时分级降水估计。为了进一步消除厚卷云和特殊地形的影响，提出使用逐日实时资料自动建立多元回归方程估计降水量，从而对双判据双重MOS多元回归法估计结果进行校正。上海中心气象台的业务使用表明，总体估计的准确率达70％左右。     

98.7湖北特大暴雨的天气分析与降水模拟

1998年7月20～23日，湖北省南部发生了一次持续性特大暴雨过程，采用双向嵌套的非静力中尺度数值模式(MM5)对这次强暴雨过程进行初步模拟试验。结果表明，粗、细网格均能较好地模拟出雨带的走向和变动以及武汉地区的暴雨中心，尤其是嵌套域(细网格)模拟的降水强度比粗网格有明显改进，和实际观测结果更接近；另外，对引发这次特大暴雨的对流层低层的中尺度系统也能够很好地模拟出来。     

2-[2-(6-氯苯并噻唑)偶氮]-5-二乙氨基苯甲酸与镍的显色反应

研究了2-[2-(6-氯苯并噻唑)偶氮]-5-二乙氨基苯甲酸(6-Cl-BTAEB)与Ni2+的显色反应。结果表明:在pH4.5～7.6的HAc-NaAc缓冲溶液中及十二烷基硫酸钠存在下,试剂与Ni2+形成稳定的蓝紫色配合物,组成为n(Ni2+)∶n(6-Cl-BTAEB)=1∶2,最大吸收波长650nm,表观摩尔吸光系数为1.59×105L·mol-1·cm-1,Ni2+浓度在0～400μg/L内符合比尔定律。用铝合金和合金钢中的微量镍验证该分析方法,所得结果与推荐值相符,6次测定的RSD<2%。     

重力、航磁资料在花岗岩型铀矿成矿研究中的应用

本文利用重磁场资料对我国南方一些花岗岩体的侵位状态和岩浆动力场进行了分析，并按动力场的强弱对岩体进行了分类。根据重力资料对苗儿山-越城岭、诸广山和贵东花岗岩体的反演计算，讨论了这些岩体的深部分布形态，提出了岩浆流动的3种方式，指出了富大铀矿床、大型铀矿聚集区的赋存部位及其与航磁异常的密切联系。     

The analysis of SPOT-5 characteristics on land cover Classification

<正>KnowledgeaboutlandcoverandlandusehasbecomeincreasinglyimportantastheNationplanstoovercometheproblemsofuncontrolleddevelopment,deterioratingenvironmentalquality,lossofprimeagriculturallandsetc.Landuseandlandcoverdataareneededintheanalysisofenvironmentalprocessesandproblemstoknowiflivingconditionsandstandardsaretobeimprovedormaintainedatcurrentlevels.     

Numerical Simulation of Wind and Temperature Fields over Beijing Area in Summer

1. IntroductionThe basic role of urban-rural boundary layer re-search is to study all kinds of physical process changesin the atmosphere boundary layer over urban and itssurrounding areas. Urban heat island (UHI) is a well-known feature of urban-rural climate. Attempts toincrease the understanding of the causes of the UHIand other urban-rural boundary layer phenomena haveused observational, theoretical and modelling methodssince long before. Seaman (1989) used a hydrostaticmodel, with real …     

Crustal structure of the Lofoten–Vesterålen continental margin, off Norway

By compiling wide-angle seismic velocity profiles along the 400-km-long Lofoten–Vesterålen continental margin off Norway, and integrating them with an extensive seismic reflection data set and crustal-scale two-dimensional gravity modelling, we outline the crustal margin structure. The structure is illustrated by across-margin regional transects and by contour maps of depth to Moho, thickness of the crystalline crust, and thickness of the 7+ km/s lower crustal body. The data reveal a normal thickness oceanic crust seaward of anomaly 23 and an increase in thickness towards the continent–ocean boundary associated with breakup magmatism. The southern boundary of the Lofoten–Vesterålen margin, the Bivrost Fracture Zone and its landward prolongation, appears as a major across-margin magmatic and structural crustal feature that governed the evolution of the margin. In particular, a steeply dipping and relatively narrow, 10–40-km-wide, Moho-gradient zone exists within a continent–ocean transition, which decreases in width northward along the Lofoten–Vesterålen margin. To the south, the zone continues along the Vøring margin, however it is offset 70–80 km to the northwest along the Bivrost Fracture Zone/Lineament. Here, the Moho-gradient zone corresponds to a distinct, 25-km-wide, zone of rapid landward increase in crustal thickness that defines the transition between the Lofoten platform and the Vøring Basin. The continental crust on the Lofoten–Vesterålen margin reaches a thickness of 26 km and appears to have experienced only moderate extension, contrasting with the greatly extended crust in the Vøring Basin farther south. There are also distinct differences between the Lofoten and Vesterålen margin segments as revealed by changes in structural style and crustal thickness as well as in the extent of elongate potential-field anomalies. These changes may be related to transfer zones. Gravity modelling shows that the prominent belt of shelf-edge gravity anomalies results from a shallow basement structural relief, while the elongate Lofoten Islands belt requires increased lower crustal densities along the entire area of crustal thinning beneath the islands. Furthermore, gravity modelling offers a robust diagnostic tool for the existence of the lower crustal body. From modelling results and previous studies on- and off-shore mid-Norway, we postulate that the development of a core complex in the middle to lower crust in the Lofoten Islands region, which has been exhumed along detachments during large-scale extension, brought high-grade, lower crustal rocks, possibly including accreted decompressional melts, to shallower levels.