从肠-肝轴角度浅析中满分消丸对NAFLD的调节作用

分析非酒精性脂肪肝（NAFLDA）“肠-肝轴”紊乱的原因,以及中满分消丸的干预作用及可能机制。NAFLD异常“肠-肝轴”,导致肠道细菌及其产物移位到肝脏,引起一系列免疫系统改变和炎症反应,是促进NAFLD发生发展的关键因素;改善肠道功能、肠道菌群,保护肠黏膜屏障,是防治NAFLD的有效途径之一。中满分消丸是临床常用方剂,对NAFLD具有良好的临床疗效,这可能与改善NAFLD中异常的“肠-肝轴”有关。     

清痹膏联合非布司他治疗急性痛风性关节炎35例临床观察

目的：观察清痹膏联合非布司他治疗急性痛风性关节的临床疗效。方法：将70例急性痛风性关节炎患者随机分为治疗组和对照组,每组各35例。对照组予双氯芬酸钠缓释片合非布司他治疗,治疗组予清痹膏外敷合非布司他治疗。结果：总有效率治疗组为94.3%,对照组为85.7%,2组比较,差异有统计学意义（P＜0.05）;2组疼痛视觉模拟评分（VAS）、尿酸（UA）、红细胞沉降率（ESR）、C反应蛋白（CRP）治疗前后组内比较,差异均有统计学意义（P＜0.05）,但治疗后组间比较,差异无统计学意义（P＞0.05）;2组不良反应发生率比较,治疗组优于对照组,差异有统计学意义（P＜0.05）。结论：清痹膏可有效缓解急性痛风性关节炎患者的关节疼痛,且不良反应较少,值得临床推广应用。     

非滑动式与滑动式拉格朗日插值法在BDS精密星历内插中的比较分析

在高精度卫星定位数据处理中,对精密星历内插处理是一项基础工作。利用拉格朗日多项式插值法,从三方面对北斗导航系统精密星历进行了内插精度分析,分别是非滑动式拉格朗日插值法在不同插值阶数下的插值精度,滑动式拉格朗日插值法在不同插值阶数下的插值精度,以及非滑动式和滑动式拉格朗日插值法在同一插值阶数下的插值精度。算例结果表明,如果将插值阶数作为横坐标,且向右为正,插值精度为纵坐标,向上为正,那么非滑动式拉格朗日插值法的插值精度与插值阶数呈现一个开口向下的抛物线关系;滑动式拉格朗日插值法的插值阶数高于7后,插值精度处于稳定且高的状态,插值误差最大值为1. 1 mm左右,均方差在0. 4 mm左右;在同一插值阶数下,滑动式拉格朗日插值法的精度高于非滑动式拉格朗日插值法的精度。     

非差模型与双差模型的定位精度比较

为了分析高精度GNSS数据处理中常用的双差模型和非差模型定位性能的差异,选取ITRF核心站组成长度不同但相对位置长期不变的基线,对2013年全年的有效数据分别采用两种模型进行解算,分析两者的相对坐标差异。结果表明:全年数据的非差解与双差解相对坐标的三维偏差序列的标准差达到8.2 mm,非差解与双差解存在定位偏差;非差解的相对坐标全年数据时间序列的平均标准差是(5.6,4.5,5.4) mm,而双差解是(3.4,3.1,4.0) mm,双差模型的解算精度和稳定性整体优于非差模型;随基线的增长,双差模型的差异呈现累积性,而非差模型的差异基本无变化,如42 m超短基线STJ2-STJO非差解和双差解全年数据的标准差分别为(6.2,4.8,5.7) mm和(3.0,2.9,3.0) mm,而487 km长基线HERS-WSRT则是(5.7,4.5,5.4) mm和(4.7,2.8,4.7) mm。     

西南印度洋中脊表层沉积物非碳酸盐组分的粒度特征及其地质意义

The carbonate-free fraction of 20 surface sediments collected from the ultraslow-spreading Southwest Indian Ridge(SWIR) was studied by grain size analysis and mineralogical analysis with X-ray powder diffraction(XRD),stereo microscopy and scanning electron microscopy(SEM). The characteristics of the carbonate-free fraction of the sediments were obtained, and related influential factors were discussed. The results show that the mean grain size of this fraction is in 1.96Φ–8.19Φ, with poorly sorting and unimodal, bimodal or irregular bimodal distribution patterns. Four grain size end members of the fraction are derived with the End Member Model method. The finest end member EM1 shows a significant contribution of terrigenous materials of the aeolian input and sediment carried by the bottom current. End member EM2 with medium size mainly reflects sediment of a siliceous bioclast origin. EM3 and EM4 are interpreted as representing the coarser volcanic materials related to bedrock weathering or volcanic activities. Multi-provenance is the dominant factor controlling the grain size pattern of the carbonate-free fraction of the sediments in that area. In addition, sediment transport processes such as the bottom current and wind are the minor factors that influence the grain size distribution of the carbonate-free fraction sediments.     

热带东印度洋SST对气候变暖和变冷的响应

The response of the eastern tropical Indian Ocean(ETIO) to heat fluxes of equal amplitude but opposite sign is investigated using the Community Earth System Model(CESM). A significant positive asymmetry in sea surface temperature(SST) is found over the ETIO—the warming responses to the positive forcing exceeds the cooling to the negative forcing. A mixed layer heat budget analysis is carried out to identify the mechanisms responsible for the SST asymmetry. Results show that it is mainly ascribed to the ocean dynamical processes, including vertical advections and diffusion. The net surface heat flux, on the contrary, works to reduce the asymmetry through its shortwave radiation and latent heat flux components. The former is due to the nonlinear relationship between SST and cloud, while the latter is resulted mainly from Newtonian damping and air-sea stability effects. Changes in the SST skewness are also evaluated, with more enhanced negative SST skewness over the ETIO found for the cooling than heating scenarios due to the asymmetric thermocline-SST feedback.     

法恩群岛

法恩群岛是北海的小岛和礁石群。最大岛豪斯岛被辟为鸟类保护区,这里大量栖息着三趾鸥。三趾鸥是典型的海洋鸟类,繁殖期主要栖息于北极海洋岸边和岛屿上,非繁殖期主要栖息于海洋上。     

非等间距GM(1,1)模型的总体最小二乘算法及其病态问题

在非等间距GM(1,1)模型中,系数矩阵中有无误差的常数项和有误差的随机项,并且系数矩阵与观测向量误差同源,即系数矩阵与观测向量中有相同的元素存在,这些相同元素应该有相同的改正数,为此本文推导了一种适合非等间距GM(1,1)模型求解的总体最小二乘算法。同时,考虑到非等间距GM(1,1)模型中存在病态问题时影响总体最小二乘计算结果的稳定性,提出对系数矩阵常数列乘以某一常数的方法,以改善病态问题。     

航空重力垂直梯度探测潜艇方法研究

航空重力梯度测量属于被动探测,抗干扰能力强,如果能和其他探潜手段相配合将极大地提高航空搜潜的效率。针对航空重力梯度测量是否能够用于探测潜艇的问题,依据俄亥俄级弹道导弹核潜艇的结构特点,建立了适用于重力梯度计算的潜艇模型,分别给出了潜艇外壳、内部质量亏损产生的重力垂直梯度的计算方法,并对不同精度重力梯度仪可探测的潜艇重力垂直梯度值进行了计算,从航空反潜的角度对探测潜艇效果进行了分析。经计算表明,如航空重力梯度仪精度达到10~(-2) E,将具备一定的实际探潜效能;如精度达到10~(-4) E,反潜机搜索宽度可与现有航空磁性探潜相当。