加味桂枝甘草龙骨牡蛎汤治疗心阳不振型室性早搏35例临床观察

目的:观察加味桂枝甘草龙骨牡蛎汤治疗心阳不振型室性早搏的临床疗效。方法：将70 例心阳不振型室性早搏患者随机分为治疗组和对照组,每组各35 例。对照组予以琥珀酸美托洛尔缓释片治疗,治疗组在对照组基础上联合加味桂枝甘草龙骨牡蛎汤治疗。比较2组治疗前后的中医证候积分、24 h室性早搏次数及不良反应发生情况,并评定综合疗效。结果：总有效率治疗组为88.57%（31/35）,对照组为62.86%（22/35）,2组比较,差异有统计学意义（P<0.01）;2组中医证候积分及24 h室性早搏次数治疗前后组内比较及治疗后组间比较,差异均有统计学意义（P<0.01）。2组均出现轻度胃部不适、恶心等不良反应,其中治疗组2 例,对照组1 例。结论：加味桂枝甘草龙骨牡蛎汤能有效改善心阳不振型室性早搏患者的症状,减少室性早搏发生次数,值得临床推广和应用。     

一株大口黑鲈源ST-873型肺炎克雷伯菌(Klebsiella pneumoniae)的分离鉴定及生物学特性研究

从患腹水病大口黑鲈(Micropterus salmoides)的头肾、脾脏、肝脏组织中分离到一株优势菌,生长出圆形、边缘整齐的灰白色黏液状菌落;染色镜检可见短粗、卵圆形、有荚膜的革兰氏阴性杆菌。结合形态、生理生化特征、16S rRNA基因序列分析鉴定为肺炎克雷伯菌(Klebsiella pneumoniae),MLST分析进一步确定其为ST-873型,与ST-65型聚为一支;该菌株携带aere、alls、wca和ybt四种毒力基因,具有溶血活性;人工感染大口黑鲈,发现患病鱼呈现腹水等与自然发病类似的症状,且病鱼内脏的分离菌株与攻毒菌株相同;经统计,其LD50为3.4×10⁷ CFU/mL,具有中等生物被膜形成能力。耐药性分析结果显示,该菌株携带bla-shv、sul2、aadA和tetB四种耐药基因,对β-内酰胺类、氨基糖苷类、喹诺酮类、黏菌素类药物敏感,对四环素类、磺胺类、林可酰胺类、利福霉素类耐药;中药三七、款冬花对分离菌株有明显抑制作用。研究探明了大口黑鲈腹水病的主要病原,可为鱼源肺炎克雷伯菌的诊断和防治提供科学依据和数据参考。     

VLBI技术的发展与展望

至今,VLBI技术经过迅猛发展,先后经历了以下三个发展阶段:传统VLBI、实时和准实时VLBI以及空间VLBI。本文分别介绍这三种VLBI技术的定义及其特点,通过对比分析其优缺点,展望VLBI技术的未来发展。     

Copper Isotopic Analysis in Geological and Biological Reference Materials by MC‐ICP‐MS

The characterisation of relative copper isotope amount ratios (δ⁶⁵Cu) helps constrain a variety of geochemical processes occurring in the geosphere, biosphere and hydrosphere. The accurate and precise determination of δ⁶⁵Cu in matrix reference materials is crucial in the effort to validate measurement methods. With the goal of expanding the number and variety of available geological and biological materials, we have characterised the δ⁶⁵Cu values of ten reference materials by MC‐ICP‐MS using C‐SSBIN model for mass bias correction. SGR‐1b (Green River shale), DOLT‐5 (dogfish liver), DORM‐4 (fish protein), TORT‐3 (lobster hepatopancreas), MESS‐4 (marine sediment) and PACS‐3 (marine sediment) have for the first time been characterised for δ⁶⁵Cu. Additionally, four reference materials (with published δ⁶⁵Cu values) have been characterised: BHVO‐1 (Hawaiian basalt), BIR‐1 (Icelandic basalt), W‐2a (diabase) and Seronorm? Trace Elements Serum L‐1 (human serum). The reference materials measured in this study possess complex and varied matrices with copper mass fractions ranging from 1.2 µg g^?1 to 497 µg g^?1 and δ⁶⁵Cu values ranging from ?0.20‰ to 0.52‰ with a mean expanded uncertainty of ± 0.07‰ (U, k = 2), covering much of the natural copper isotope variability observed in the environment.     

Changes in Agricultural Biodiversity： Implications for Sustainable Livelihood in the Himalaya

Himalayan mountain system is distinguished globally for a rich biodiversity and for its role in regulating the climate of the South Asia.Traditional crop-livestock mixed farming in the Himalaya is highly dependent on forests for fodder and manure prepared from forest leaf litter and livestock excreta. Apart from sustaining farm production, forests provide a variety of other tangible and intangible benefits, which are critical for sustainable livelihood of not only 115 million mountain people, but also many more people living in the adjoining plains. Extension of agricultural landuse coupled with replacement of traditional staple food crops by cash crops and of multipurpose agroforestry trees by fruit trees are widespread changes. Cultivation of Fagopyrum esculentum,Fagopyrum tataricum, Panicum miliaceum, Setaria italica and Pisum arvense has been almost abandoned. Increasing stress on cash crops is driven by a socio-cultural change from subsistence to market economy facilitated by improvement in accessibility and supply of staple food grains at subsidized price by the government. Farmers have gained substantial economic benefits from cash crops. However, loss of agrobiodiversity implies more risks to local livelihood in the events of downfall in market price/demand of cash crops, termination of supply of staple food grains at subsidized price, pest outbreaks in a cash crop dominated homogeneous landscape and abnormal climate years. Indigenous innovations enabling improvement in farm economy by conserving and/enhancing agrobiodiversity do exist, but are highly localized. The changes in agrobiodiversity are such that soil loss and run-off from the croplands have dramatically increased together with increase in local pressure on forests. As farm productivity is maintained with forest-based inputs, continued depletion of forest resources will result in poor economic returns from agriculture to local people,apart from loss of global benefits from Himalayan forests. Interventions including improvement in traditional manure and management of on-farm trees,participatory development of agroforestry in degraded forest lands and policies favoring economic benefits to local people from non-timber forest products could reduce the risks of decline in agricultural biodiversity and associated threats to livelihoods and Himalayan ecosystems.     

Evaluating functional connectivity in a small agricultural catchment under contrasting flood events by using UAV

Concentrated erosion, a major feature of land degradation, represents a serious problem for soil and water resources management and a threat to ecosystems. Understanding the internal mechanisms (de-)coupling sediment pathways can improve the management and resilience of catchments. In this study, concentrated erosion and deposition forms were mapped accurately through field and aerial unmanned aerial vehicle (UAV) campaigns, in order to assess the evolution of connectivity pathways over a series of three contrasted and consecutive flood events occurring between October 2016 and January 2017 (return period ranging from 0.5 to 25 years) in a small Mediterranean agricultural catchment (Can Revull, Mallorca, Spain; 1.4 km²). In addition, a morphometric index of connectivity (IC) was used to identify the potential trajectories of different concentrated erosion forms and deposition areas. IC predictions were calibrated by identifying the optimal critical thresholds, i.e. those most consistent with field observations after each of the events studied. The results found that the index performed well in predicting the occurrence and the length/area of the different type of landforms, giving kappa (κ) coefficients of variation ranging between 0.21 and 0.92 and linear correlations R² between 0.33 and 0.72. The type of landform affected the correspondence of IC predictions and field observations, with lower thresholds the greater the magnitude of their associated geomorphic processes. Rainfall magnitude proved to be a very important factor controlling the development of erosion and deposition landforms, with large differences in length/area between the contrasted events. The evolution of the observed trajectories revealed feedback dynamics between the structural and functional connectivity of the catchment, in which morphological changes determined the spatial distribution of the processes’ activity in the successive events and vice versa. © 2020 John Wiley & Sons, Ltd.     

首都圈东部地区震群序列性质判定

采用传统方法和数字地震学方法（视应力）,对首都圈东部地区2009-2017年发生的震群序列性质进行分析,分析结果表明：①使用传统方法不能确定震群序列性质,可以利用视应力方法进一步分析,该方法能够反映每个震群应力场的变化特征,可以进行异常性质判别;②通过2种方法的对比分析,可以提高震群序列异常性质判定结果的科学性和可信度,为后续地震活动趋势提供有力的参考依据。对2种方法进行震例检验,可知后续地震一般为中等以上地震,在震群（具有异常性质）发生1-7个月后发震,发震位置在震源区附近。     

Optimum design and application of non‐traditional tuned mass damper toward seismic response control with experimental test verification

A variant type of tuned mass damper (TMD) termed as ‘non‐traditional TMD (NTTMD)’ is recently proposed. Mainly focusing on the employment of TMD for seismic response control, especially for base‐isolated or high‐rise structures, this paper aims to derive design formulae of NTTMDs based on two methodologies with different targets. One is the fixed points theory with the performance index set as the maximum magnitude of the frequency response function of the relative displacement of the primary structure with respect to the ground acceleration, and the other is the stability maximization criterion (SMC) to make the free vibration of the primary structure decay in the minimum duration. Such optimally designed NTTMDs are compared with traditional TMDs by conducting both numerical simulations and experiments. The optimum‐designed NTTMDs are demonstrated to be more effective than the optimum‐designed traditional TMDs, with smaller stroke length required. In particular, the effectiveness of the TMDs combined with a base‐isolated structure is investigated by small‐scale model experimental tests subjected to a time scaled long period impulsive excitation, and it is demonstrated that the SMC‐based NTTMD can suppress structural free vibration responses in the minimum duration and requires much smaller accommodation space. Additionally, a small‐scale shaking table experiment on a high‐rise bending model attached with a SMC‐based NTTMD is conducted. This study indicates that NTTMD has a high potential to apply to seismic response control or retrofit of structures such as base‐isolated or central column‐integrated high‐rise structures even if only a limited space is available for accommodating TMDs. Copyright © 2015 John Wiley & Sons, Ltd.     

传统农林复合系统:一种全球重要文化遗产类型(英文)

作为一种土地利用活动,传统农林复合系统已经经历了成百上千年的历史,并且依然发挥着重要的作用在世界上,特别是热带和亚热带地区。在全球变化和粮食安全等危机的时代背景下,传统农林复合系统受到越来越多政府和非政府组织的重视,因为传统农林复合系统具有重要的经济、生态和社会文化效益。这与全球重要农业文化遗产要求的特征也相一致,目前为止,已经有5个国家4个典型的传统农林复合系统被列为全球重要农业文化遗产。这些传统农林复合系统具有丰富的农业生物多样性,多重的生态系统服务功能,重要的社会文化价值,无论在区域还是全球水平上。目前传统农林复合系统面临一些威胁和挑战,如人口迁移、市场冲击、气候变化等,但是只要政府和非政府组织、社区、农民之间采取多种方式紧密合作,在未来的全球土地利用活动中,传统农林复合系统必将得到有效保护和推广。     

Evaluation ofAntitumor, Immunomodulatory and Free Radical Scavenging Effects of A New Herbal Prescription Seaweed Complex Preparation

Seaweed Complex Preparation （SCP） is a clinical traditional Chinese medicine preparation which is composed of seven traditional Chinese herbs, and it has been used for treatment of lung cancer, liver cancer and digestive cancer. However, little infor- mation is available about the pharmacodynamic basis. The antitumor, immunomodulatory and free radical scavenging effects of SCP were evaluated in this study. Transplanted tumor in vivo method was used to determine the antitumor effect. The effects on spleno- cyte proliferation and phagocytosis of macrophages in tumor-bearing mice were measured by the MTT method and the phagocytizing cock red blood cell （CRBC） method respectively. The scavenging activities of SCP on DPPH and hydroxyl radicals in vitro were investigated. It was found that the medium-dose and high-dose of SCP could significantly inhibit the growth of transplanted hepatic tumor of murine hepatocarcinoma cell line H22, and promote proliferation of splenocytes and phagocytosis of macrophages. SCP possessed noticeable scavenging activities on DPPH and hydroxyl radicals. The antiturnor effects of SCP might be achieved by im- proving immune system and scavenging free radicals, which is in accordance with the viewpoint of traditional Chinese medicine in promoting the body resistance and eliminating pathogenic factors for cancer treatment.