基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

Reconstruction of the diagenesis of the fluvial-lacustrine- deltaic sandstones and its influence on the reservoir quality evolution-- Evidence from Jurassic and Triassic sandstones, Yanchang Oil Field, Ordos Basin

The reservoir quality of Jurassic and Triassic fluvial and lacustrine-deltaic sandstones of the Yanchang Oil Field in the Ordos Basin is strongly influenced by the burial history and facies-related diagenetic events. The fluvial sandstones have a higher average porosity (14.8%) and a higher permeability (12.7×10?3 ?m2) than those of the deltaic sandstones (9.8% and 5.8 ×10?3 ?m2, respectively). The burial compaction, which resulted in 15% and 20% porosity loss for Jurassic and Triassic sandstones, respectively, is the main factor causing the loss of porosity both for the Jurassic and Triassic sandstones. Among the cements, carbonate is the main one that reduced the reservoir quality of the sandstones. The organic acidic fluid derived from organic matter in the source rocks, the inorganic fluid from rock-water reaction during the late diagenesis, and meteoric waters during the epidiagenesis resulted in the formation of dissolution porosity, which is the main reason for the enhancement of reservoir-quality.     

Evapotranspiration from citrus trees growing in sandy soilunder drip irrigation with saline water

An experiment on evapotranspiration from citrus trees under irrigation with saline waterwas carried out for 4 months. Two lysimeters planted with a citrus tree in the green house wereused. One lysimeter was irrigated with saline water (NaCl and CaCl2 of 2000 mg/L equivalence,EC = 3.8 dS/m, SAR = 5.9) and the other was irrigated with freshwater using drip irrigation. Theapplied irrigation water was 1.2 times that of the evapotranspiration on the previous day.Evapotranspiration was calculated as the change in lysimeter weight recorded every 30 minutes.The lysimeters were filled with soil with 95.8% sand. The results of the experiment were as follows.(i) The evapotranspiration from citrus tree was reduced after irrigation with saline water. Theevapotranspiration returns to normal after leaching. However it takes months to exhaust the saltfrom the tree. ( ii ) To estimate the impact of irrigation with saline water on the evapotranspirationfrom citrus trees, the reduction coefficient due to salt stress (Ks) was used in this experiment.Evapotranspiration under irrigation with saline water (ETs) can be calculated from evapotranspira-tion under irrigation with freshwater (ET) by the equation ETs = Ks× ET. Ks can be expressed as afunction of ECsw. (iii) The critical soil-water electrical conductivity (ECsw) is 9.5 dS/m, beyondwhich adverse effects on evapotranspiration begin to appear. If ECsw can be controlled at below9.5 dS/m, saline water can be safely used for irrigation.     

To afforest the desert with the technology of peat composed of rotten mosses and the sustainable development of the oases

Only by providing the good conditions for the growth of plants can a favorable ecologicalenvironment on which human beings rely for existence be created. The upside-down-T dou-ble-layer water-conserving afforestation way is developed according to the situation of the short-age of water resources, low soil fertility and vast land in the arid areas. The characteristics of theafforestation way are to change the microenvironment in the root area of the plants, provide thefavorable conditions for the growth of plants, and reduce the necessary conditions for the growth ofplants in large areas in the arid regions. Meanwhile, the size of its water-conserving layer can bechanged according to the size of the planted trees. The different ways of the bottom wa-ter-conserving layer can be used according to the requirements. The afforestation way is suitablefor planting trees on a small scale and also for afforesting on a large scale under the adverse cir-cumstances in the arid areas, and has been effectively used in the afforestation in the hinterland ofTaklamakan Desert and the southern marginal zone of Gurbantonggut Desert. The prospects ofthe afforestation way are broad in afforestation and desertification control in the desert regions.     

几何光学冠层反射建模中的光谱分量特征的参数化(英文)

该文用几何光学与辐射传输混合模型研究不连续植被冠层的几何光学反射模型的四分量（承照树冠、承照地面、阴影树冠、阴影地面）的参数化。用一个修正的均匀介质层路径散射（反射与传输）参数的解析算法估计路径散射参数（反射与传输），其中也考虑了冠层间隙的影响。光谱分量特征是不连续植被冠层的传输与反射，背景反照率，以直射光通量与天空漫射光通量比例的函数。光谱分量特征的模型与在美国缅因州Ｈｏｌａｎｄ采集的针叶林数据吻合。基于ＬｉＳｔｒａｈｌｅｒ几何光学相互遮蔽模型，用参数化的光谱分量特征对老松林和老云杉林的方向反射进行估计，其结果与在不同太阳与观测方向上的ＰＡＲＡＢＯＬＡ测量值匹配得很好。     

用航空POLDER测量仪获取的方向性信息增强对北方森林冠层的识别(英文)

ＰＯＬＤＥＲ（地球反射极化和方向）仪器在ＢＯＲＥＡＳ实验中曾搭载ＮＡＳＡ的一架Ｃ１３０飞机飞行。在ＢＯＲＥＡＳ的南部地区，ＰＯＬＤＥＲ获取了各种实验场地上的ＢＲＤＦ测量值。森林覆盖地区的大的热点特征，以及十个地区上的镜面反射分量得到了描述。该文通过ＰＯＬＤＥＲ的测量数据，对向常规的光谱特征中加入通过遥感获得的方向性特征后，对各种森林覆盖的分类和区分能力的提高给出了定量化的解。当将方向信息加入常规光谱信息后，采用无监督分类时，类间耦合矩阵的各项显著减小（减小倍数为２－５倍）。这一事实证明了用遥感方向特征可以增强对ＢＯＲＥＡＬ森林覆盖的区分能力。     

2003年5月4日新疆伽师-岳普湖5.8级地震烈度分布及建筑物结构破坏特点

新疆伽师-岳普湖5．8级地震宏观震中位于岳普湖县的铁热木乡和兵团农三师42团的北面，震中烈度为Ⅶ度。本次地震影响范围位于巴楚-伽师6．8级地震Ⅵ-Ⅶ度影响区域内，累计破坏效应造成了较为严重的房屋破坏。通过对大量震害资料和强震记录的分析，根据建筑物的破坏情况和场地峰值加速度衰减特征，在尽可能排除累计破坏效应的基础上确定了地震烈度分布，分析了不同烈度区中的建筑物结构破坏特点及其与地震动影响场的关系。     

CHARACTERISTICS OF ATMOSPHERIC HEAT SOURCE ASSOCIATED WITH THE SUMMER MONSOON ONSET OVER THE SOUTH CHINA SEA AND THE POSSIBLE MECHANISM RESPONSIBLE FOR ITS LATE OR EARLY ONSET

The characteristics of atmospheric heat source associated with the summer monsoon onset in the South China Sea (SCS) are studied using ECMWF reanalysis data from 1979 to 1993. A criterion of the SCS summer monsoon onset is defined by the atmospheric hea…     

中国周边地区强震与中国大陆7级以上地震活动的关系

通过对中国周边地区强震与中国大陆地区强震活动的关系分析，发现中国大陆周边地区活跃时段期间和其后3年是中国大陆地区7级以上地震活动的主要活动时期，周边地区强震活动增强后，中国大陆内部有可能发生7级以上地震，强震活动可能会逐步进入高潮，南北地震带中段未来数年发生7级以上地震的危险性较大．