论国家对人力资源生产和再生产的宏观调控

国家宏观调控的实质是从社会经济运行和发展的全局出发，按照预定的目标，对社会经济的决量和总体结构进行调节和管理。在社会主义市场经济条件下，人力资源的生产和再生产各个环节的经济关系错综复杂经济，人力资源生产和再生产与物质资料的生产和再生产之间也涉及方方面面的经济利益关系。市场在调节经济关系中发挥着基础性作用，但由于市场机制的运行本质上在于利益驱动，这必然造成市场失灵和市场激励机制作用的局限性，从而要求国家加强对人力资源生产和再生产中的经济关系的宏观调控。     

基于网络药理学和分子对接技术探究柯里拉京治疗卵巢癌的关键靶点及分子机制

目的：采用网络药理学和分子对接技术相结合的方法探究柯里拉京（Cor）治疗卵巢癌的关键作用靶点和分子机制。方法：利用PharmMapper、TargetNet及Swiss Target Prediction在线工具预测Cor的作用靶点,通过OMIM、TTD、CTD、DisGenet、PharmGKB及MalaCards数据库获取卵巢癌相关的疾病靶点,并将药物靶点与疾病靶点取交集得到Cor治疗卵巢癌的预测靶点。借助STRING数据库、Cytoscape 软件构建蛋白质-蛋白质相互作用（PPI）网络,并采用CentiScape插件筛选出PPI网络中的核心靶点。运用GEPIA和Kaplan-Meier Plotter在线平台分别对这些核心靶点进行基因表达差异分析和生存分析,以明确Cor治疗卵巢癌的关键靶点。利用DAVID数据库进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析。运用Autodock Vina软件进行正向分子对接,预测关键靶点和Cor之间的结合活性。结果：Cor治疗卵巢癌的预测作用靶点共24个,其中RAC-α丝氨酸/苏氨酸蛋白激酶(AKT1)、表皮生长因子受体(EGFR)、雌激素受体1(ESR1)、原癌基因酪氨酸蛋白激酶(SRC)是Cor治疗卵巢癌的关键靶点,主要涉及血管内皮生长因子(VEGF)信号通路、缺氧诱导因子-1(HIF-1)信号通路及叉头样转录因子(FoxO)信号通路,可能通过调控细胞凋亡、细胞增殖、血管内皮细胞迁移等生物过程而发挥治疗卵巢癌的作用。分子对接结果显示,Cor与预测靶点之间具有较好的亲和力,表明通过网络药理学预测作用靶点的方法具有良好的可靠性。结论：Cor是通过多靶点、多通路的协同作用来干预多个生物过程,从而发挥其抗卵巢癌疗效,为进一步研究其治疗卵巢癌的分子机制提供了新的线索。     

Sedimentary characteristics and genetic mechanism of the giant ancient pockmarks in the Qiongdongnan Basin,northern South China Sea

In the late Miocene, giant ancient pockmarks, which are fairly rare globally, developed in the Qiongdongnan Basin. In this paper, to determine the sedimentary characteristics and genetic mechanism of these giant ancient pockmarks in the Yinggehai Formation of the Qiongdongnan Basin, based on high-resolution 3D seismic data and multiattribute fusion technologies, we analyzed the planar distribution and seismic facies of the ancient pockmarks and compared the characteristics of the ancient pockmar...     

New interpretation on the provenance changes of the upper Pinghu–lower Huagang Formation within Xihu Depression,East China Sea Shelf Basin

Both Pinghu and Huagang formations are important hydrocarbon reservoirs of the Xihu Depression in the East China Sea Shelf Basin. Clarifying the source suppliers and restoring source-to-sink transport routes are of great significance to the future petroleum and gas undertakings. Previous researchers were largely confined by either limitation of geological records, highly dependence on a singular method or low-precision dating techniques. Our study integrated heavy mineral assemblages, geochemica...     

Defining the concept of stratigraphic grade and applying it to stratal (reservoir) architecture and evolution of the slope-to-basin profile: An outcrop perspective

Stratigraphic grade is the similarity of the morphology of successive slope-to-basin profiles in a genetically related depositional system. In this article we use data collected from regional cross-sections of six depositional systems, stratal architecture derived from outcrops of the Lewis Shale (Wyoming, USA), and the Ross Sandstone (Ireland), and supplementary outcrop and subsurface data from other depositional systems to determine how stratigraphic grade relates to stratal (reservoir) architecture in deepwater systems.Four methods are developed that collectively define stratigraphic grade: (1) regional stacking patterns of fourth-order stratigraphic surfaces, (2) the relationship between the trajectory of the shelf edge (T_se) and the trajectory of the depocenter (T_d) for fourth-order stratigraphic units, (3) morphology of the slope-to-basin profiles of fourth-order stratigraphic surfaces, and (4) the similarity of the morphologies of slope-to-basin profiles of fourth-order surfaces in a system (σ_s, σ_r). Several characteristics of stratigraphic (reservoir) architecture of fourth-order stratigraphic cycles are related to stratigraphic grade: (1) longitudinal distribution of sandstone in fourth-order cycles, (2) location of maximum sandstone relative to the depocenter of fourth-order cycles, (3) lengths of fourth-order submarine fans, and (4) longitudinal and vertical distribution of architectural elements. Stratigraphic grade is thus a predictor of reservoir architecture and can thereby be used to reduce the uncertainty in the interpretation of subsurface data.The concept of stratigraphic grade is useful in understanding the stratigraphic evolution of deepwater systems. Most deepwater systems analyzed in this study initiated as out-of-grade and temporally evolved to graded systems over a time span of millions of years. Systems rarely evolve from graded to out-of-grade. First-order controls on stratigraphic grade are determined to be angle of slope, tectonically forced changes in angle of slope during deposition, and sediment supply.     

Composition, porosity, and reservoir potential of the Middle Jurassic Kashafrud Formation, northeast Iran

In the Kopet-Dagh Basin of Iran, deep-sea sandstones and shales of the Middle Jurassic Kashafrud Formation are disconformably overlain by hydrocarbon-bearing carbonates of Upper Jurassic and Cretaceous age. To explore the reservoir potential of the sandstones, we studied their burial history using more than 500 thin sections, supplemented by heavy mineral analysis, microprobe analysis, porosity and permeability determination, and vitrinite reflectance.The sandstones are arkosic and lithic arenites, rich in sedimentary and volcanic rock fragments. Quartz overgrowths and pore-filling carbonate cements (calcite, dolomite, siderite and ankerite) occluded most of the porosity during early to deep burial, assisted by early compaction that improved packing and fractured quartz grains. Iron oxides are prominent as alteration products of framework grains, probably reflecting source-area weathering prior to deposition, and locally as pore fills. Minor cements include pore-filling clays, pyrite, authigenic albite and K-feldspar, and barite. Existing porosity is secondary, resulting largely from dissolution of feldspars, micas, and rock fragments, with some fracture porosity. Porosity and permeability of six samples averages 3.2% and 0.0023 mD, respectively, and 150 thin-section point counts averaged 2.7% porosity. Reflectance of vitrinite in eight sandstone samples yielded values of 0.64-0.83%, in the early mature to mature stage of hydrocarbon generation, within the oil window.Kashafrud Formation petrographic trends were compared with trends from first-cycle basins elsewhere in the world. Inferred burial conditions accord with the maturation data, suggesting only a moderate thermal regime during burial. Some fractures, iron oxide cements, and dissolution may reflect Cenozoic tectonism and uplift that created the Kopet-Dagh Mountains. The low porosity and permeability levels of Kashafrud Formation sandstones suggest only a modest reservoir potential. For such tight sandstones, fractures may enhance the reservoir potential.     

珠江口盆地东沙隆起的沉降史及其动力机制

根据东沙隆起及其周围钻井资料的一维构造沉降对比分析,结合前人在基底、盖层及断裂等方面的研究,将东沙隆起地区的构造演化分为5个阶段:自垩纪挤压阶段、古新世-早渐新世伸展断陷阶段、早渐新世末期抬升剥蚀阶段、晚渐新世-中新世快速的裂后沉降阶段、晚中新世以来断块升降阶段.认为下地壳高速层是促使早渐新世末期抬升剥蚀的重要因素,而...     

渤海湾盆地沙河街组钙质超微化石古生态及沉积环境

渤海湾盆地沙河街组中钙质超微化石的发现,表明这一时期渤海湾盆地与海水有过联系。对钙质超微化石古生态及沉积环境研究表明,化石主要产出时代为始新世晚期至渐新世早中期,属“间冰期”亚热带气候型。这一问题的深入研究,对于渤海湾盆地的石油勘探有重要意义。     

厄尔尼诺的发生与行星运动

厄尔尼诺(El Ni(?)o)现象是海-气耦合系统异常变化的表现,其起因可能不是唯一的,行星运动对地球运动的影响可能会导致El Ni(?)o的发生。根据4个半世纪内El Ni(?)o发生的历史资料,分析其发生和行星运动的关系,得出的结论是:木星赤纬的变化和火星大冲与El Ni(?)o。的发生有显著的关系,表明这2颗行星的运动可能影响El Ni(?)o的发生。文中还根据分析结桌和El Ni(?)o混沌机制的观点,探讨了行星运动对海-气系统变化的影响机制。     

南海北部冬季和夏季逆风流机制初探Ⅱ.季风逆风流产生机制

分析讨论了季风风应力、大陆坡地形及底摩擦在产生季风逆风流的必要条件和间接逆风流诊断判据中的作用；应用季风逆风流必要条件和间接逆风流诊断判据，解释冬季风和夏季风逆风流是如何产生的。结果表明：季风风应力是产生季风逆风流的主导因素；冬季风风应力、大陆坡地形及底摩擦三者联合作用导致表层海水在大陆坡上产生辐合生成高水位带和高动力高度带，在大陆被北侧产生NE向的冬季逆风流，南侧产生SW向顺风流；夏季风风应力、大陆坡地形及底摩擦三者联合作用导致表层海水在大陆坡上产生辐散生成低水位带和低动力高度带，在大陆被北侧产生SW向的夏季逆风流，南侧产生NE向的顺风流；冬季风盛行期间，风致经巴士海峡流入南海的黑潮水，将加速冬季逆风流的形成，加大冬季逆风流的强度；夏季风盛行期间，风应力的作用使巴上海峡以东的黑潮水不能进入南海，即使别的原因令巴上海峡以东的黑潮水流入南海，但高温、高盐的黑潮水对夏季逆风流具有阻扼作用。