高邮凹陷戴南组断层－岩性油藏断层输导性能及演化

基于高邮凹陷戴南组断层－岩性油藏断层现今与成藏期垂向正应力分析,研究断层垂向封闭性演化规律,并结合断层垂向输导模式划分,预测高邮凹陷戴南组断层－岩性油藏有利分布区。研究结果表明,断层垂向封闭性的临界正应力值为13.8 MPa,多数控藏断层在成藏期开启作为输导通道,现今则封闭成为遮挡条件,但偶有例外,邵深1油藏控藏断层在成藏期与现今皆封闭,此类油藏极有可能是自生自储;高邮凹陷发育有两种垂向输导模式,分别为高通和低通垂向输导模式,其中高通垂向输导模式中戴南组底砂岩发育,低通垂向输导模式戴南组底砂岩不发育。在断层封闭性演化研究和输导模式划分的基础上,认为联12油藏以东－永22油藏以西及邵14油藏以东伯东地区是高邮凹陷戴南组断层－岩性油藏发育的有利区带,邵深1油藏西北的邵伯次凹深处是断层－岩性油藏发育的较有利区带。     

无鱼粉日粮条件下黄颡鱼生长性能和肝胰脏转录组差异表达的研究

本研究以黄颡鱼(Pelteobagrus fulvidraco)为试验对象,设计两种饲料:鱼粉组和无鱼粉组,在池塘网箱中投喂70 d,研究其生长性能和肝胰脏转录组表达的差异。同鱼粉组相比,无鱼粉组黄颡鱼特定生长率下降了30.25%(P0.05),饲料系数显著增加了83.94%(P0.05),全鱼脂肪含量显著下降(P0.05),血清甘油三酯含量显著下降(P0.05),血清转氨酶活力显著增加(P0.05)。肝胰脏转录组结果显示,总计有12 020个基因差异表达,其中差异表达上调的基因有5 020个、差异表达下调的基因有7 000个。同鱼粉组相比,无鱼粉组分别有1 013个基因表达显著上调、2749基因表达显著下调(P0.05)。将组间具有差异表达的基因进行GO Term、KEGG pathway分类,结果显示:无鱼粉组的肝胰脏细胞组成、细胞生物过程、细胞分子功能等绝大多数基因差异表达下调,提示肝胰脏的细胞组织结构和功能受到很大的影响;KEGG通路富集到15个显著差异代谢通路。本研究结果表明,日粮中鱼粉可能含有某些生理活性物质,这些物质以神经分泌、激素调控、代谢信号通路等为作用靶点,通过对这些代谢信号通路的调节,对鱼的整体生理代谢强度、细胞结构与功能、生理健康状态等产生明显积极促进影响。缺乏这些物质则会造成黄颡鱼生长性能下降、部分器官组织细胞(肝细胞、神经轴突)受到损伤、鱼体抗应激能力和免疫防御能力下降。     

鄂尔多斯盆地旬邑地区三叠系延长组长9储层成岩作用及成岩相

通过铸体薄片、扫描电镜、高压压汞等方法对鄂尔多斯盆地旬邑地区三叠系延长组孔隙演化,并对储层成岩相进行划分。结果表明：旬邑地区长9 储层主要以长石砂岩和岩屑长石砂岩为主。压实作用及胶结作用是造成储层物性变差的主要原因,压实作用造成孔隙度降低约15.5%,胶结作用造成孔隙降低约13.6%。溶蚀作用对储层孔隙改善不明显,仅增加孔隙度约为1.98%。通过分析影响储层物性的主要成岩作用,综合实验测试数据将长9储层划分为4种成岩相：绿泥石膜-粒间孔相、长石溶孔-粒间孔相、碳酸盐致密胶结微孔相及塑性岩屑压实致密相等。其中绿泥石膜-粒间孔相、长石溶孔-粒间孔相为有利的成岩相带,主要分布在砂体中部区域。     

夏季青藏高原大气热源准双周振荡及其传播途径

采用1979—2017年NCEP/NCAR逐日再分析资料估算大气热源,研究夏季青藏高原大气热源准双周振荡(Quasi-BiWeekly Oscillation,QBWO)的特征及传播途径。结果表明:青藏高原及其周边的大气热源QBWO的前两个主模态,即荷载中心在高原东南部的全区一致型和高原东南-西北反位相变化的偶极型,呈现了高原夏季大气热源QBWO自东向西传播过程中所处的两种不同状态。这主要是由于在中纬度地区对流层中上层,低频大气环流的活动表现为大的异常气旋和反气旋环流从我国东北经青藏高原至西亚的自东向西的传播,当移近高原时迅速增强,当西移离开高原时明显减弱。在此过程中,青藏高原及其周边、孟加拉湾以及印度半岛等地区的降水都发生了异常变化。     

参苓白术散对NAFLD大鼠肝细胞、Kupffer细胞mTOR通路相关基因及蛋白表达影响的实验研究

目的：观察参苓白术散对非酒精性脂肪性肝病（NAFLD）大鼠肝细胞、Kupffer细胞、哺乳动物雷帕霉素靶蛋白（mTOR）通路相关基因及蛋白表达的影响,以阐明参苓白术散抗NAFLD的作用机制。方法：将80只大鼠随机分为正常组,模型组及参苓白术散低、高剂量组。对模型组、各药物组连续8周喂养高脂饲料制备NAFLD大鼠模型。造模成功后采用油红O染色观察肝组织病理变化;Ⅳ型胶原酶离体循环灌注法分离肝细胞、Kupfer细胞;全自动生化仪检测血清总胆固醇（TC）、三酰甘油（TG）;酶联免疫吸附法测定肝细胞及Kupffer细胞血管内皮生长因子（VEGF）、干扰素（IFN）-γ含量;实时荧光定量PCR及蛋白质印迹法（Western blot）检测大鼠肝细胞及Kupffer细胞脑内富含的小G蛋白Ras同系物（Rheb）、mTOR复合物1（mTORC1）、核糖体S6蛋白激酶1（S6K1）和真核细胞翻译起始因子4E-结合蛋白1（4E-BP1）mRNA和蛋白表达。结果：模型组大鼠肝组织存在严重的脂质蓄积。血清TC、TG,肝细胞、Kupffer细胞,VEGF、IFN-γ含量,以及Rheb、mTORC1、S6K1、4E-BP1 mRNA和蛋白表达水平较正常组显著升高（P<0.01）,说明造模成功。与模型组比较,各药物干预组血清TC、TG,肝细胞、Kupffer细胞,VEGF、IFN-γ含量,以及Rheb、mTORC1、S6K1、4E-BP1 mRNA和蛋白表达均有不同程度的下调（P<0.05或P<0.01）。其中参苓白术散高剂量组下调趋势最为显著,与低剂量组比较,差异均有统计学意义（P<0.05或P<0.01）。结论：参苓白术散抗NAFLD的作用机制可能与抑制肝细胞及Kupffer细胞mTOR通路中Rheb、mTORC1、S6K1、4E-BP1基因及蛋白表达有关。     

Carbon and hydrogen isotopic composition and generation pathway of biogenic gas in China

The carbon and hydrogen isotopic composition of biogenic gas is of great importance for the study of its generation pathway and reservoiring characteristics. In this paper, the formation pathways and reservoiring characteristics of biogenic gas reservoirs in China are described in terms of the carbon and hydrogen isotopic compositions of 31 gas samples from 10 biogenic gas reservoirs. The study shows that the hydrogen isotopic compositions of these biogenic gas reservoirs can be divided into three intervals: δ>−200‰, −250‰<δ<-−200‰ and δ<−250‰. The forerunners believed that the main generation pathway of biogenic gas under the condition of continental fresh water is acetic fermentation. Our research results showed that the generation pathway of biogenic gas under the condition of marine facies is typical CO₂- reduction, the biogenic gas has heavy hydrogen isotopic composition: its δ values are higher than −200‰; that the biogenic gas under the condition of continental facies also was generated by the same way, but its hydrogen isotopic composition is lighter than that of biogenetic gas generated under typical marine facies condition: −250‰<δ<−200‰, the δ values may be related to the salinity of the water medium in ancient lakes. From the relevant data of the Qaidam Basin, it can be seen that the hydrogen isotopic composition of biogenic methane has the same variation trend with increasing salinity of water medium. There are biogenic gas reservoirs formed in transitional regions under the condition of continental facies. These gas reservoirs resulted from both CO₂-reduction and acetic fermentation, the formation of which may be related to the non-variant salinity of ancient water medium and the relatively high geothermal gradient, as is the case encountered in the Baoshan Basin. The biogenic gas generating in these regions has light hydrogen isotopic composition: δ<−250‰, and relatively heavy carbon isotopic composition. There is a fairly strong negative correlation between the carbon isotopic composition and the hydrogen isotopic composition. The generation mechanism and pathway of carbon, and the hydrogen isotopic composition of biogenic gas may be used to ascertain whether biogenic gas samples from the natural world are of industrial utilization value. In general, the biogenic gas formed by way of acetic fermentation is not propitious to the formation of gas reservoirs.     

塔中地区早古生代单源三位油气成藏体系

以油气成藏体系先进理论为指导,对塔里木盆地塔中地区下古生界油气成藏条件进行了研究。发现塔中地区早古生代成藏体系的油气来源于塔中北坡的烃源岩,油气沿不整合面和志留系砂岩作侧向运移,再沿断裂向上运移,最后在适合油气聚集的场所成藏。结果表明,塔中早古生代成藏体系的烃源岩、输导体系和圈闭均为分离状,油气来源单一,为塔中早古生代单源三位成藏体系。     

中国土地规划管理及其改革

2014年7月2日下午,上海市地质调查研究院副总工程师李勤奋教授、上海市地质调查研究院总工程师办公室副主任兼《上海国土资源》编辑部主任龚士良教授专程赴北京拜访了中国社会科学院农村发展研究所宏观经济研究室主任党国英研究员,并代表《上海国土资源》期刊作了专题访谈。党主任深刻剖析了中国现有土地制度存在的不足,指出土地制度的改革应以土地要素的市场化为导向,体现效率、平等、稳定和可持续,统一城乡建设用地市场。现有的国家土地规划管理体制存在弊端,应简政放权,详规下沉到最基层;要坚持以人为本,切实降低公共空间的占地面积,努力提高公民的居住空间与生活品质。     

MiR-430 Can Affect the Mesoderm Formation and Metamorphosis of Paralichthys olivaceus by Targeting lefty Gene

MiR-430 is a non-coding small RNA that participates in early embryonic development by acting on the Nodal signaling pathway.Its functions in Paralichthys olivaceus(P.olivaceus),however,remain unclear.In this study,through biological information technology,we hypothesized lefty was the target gene of miR-430.Lefty is a divergent member of the transforming growth factor-β(TGF-β)superfamily,and is involved in regulating left-right patterning as an antagonist of the Nodal signaling pathway.To study the relationship between miR-430 and lefty gene,miR-430 and fluorescent expression vector were transfected into embryo cells.Our results showed that miR-430 has important effects on early embryonic development.It can inhibit the expressions of lefty and other genes related to Nodal signaling pathway.Additionally,the expression of miR-430 was involved in the metamorphosis of P.olivaceus.This study clarifies the function of miR-430 in P.olivaceus,which will be helpful for further research on the interactions between miR-430 and the Nodal signaling pathway.     

翡翠贻贝对多氯联苯吸收不同途径的比较研究

定量分析和比较翡翠贻贝Perna viridis对多氯联苯(PCBs)吸收的4种不同途径。结果表明，翡翠贻贝通过食物途径富集PCBs比从海水吸收的途径具更高效率；而通过底泥或悬浮颗粒积累PCBs的途径较为次要。翡翠贻贝对5—7个氯原子数的PCBs异构体富集率高，分别占PCBs总量的53．25％-77．41％。结果还表明，贻贝经沉积物途径和经滤食悬浮颗粒途径比经水途径和食物途径对含2—4个氯原子数和8—10个氯原子数的PCBs异构体富集率较高。