Field observations of waves generated by passing ships: A note

This short contribution reports the results of a field study on the nearshore characteristics of waves generated by both conventional and high speed passenger ferries. The field observations took place in the late summer of 2005, at a beach close to the port of Mytilene (Island of Lesbos, Greece), and involved the visual observation of ship waves, using digital video recordings and image processing techniques. The results showed that passage of the fast ferry was associated with a longer, more complex and energetic nearshore event; this event not only did include higher nearshore waves (up to 0.74 m) and was organised in different wave packets, but it was also an order of magnitude longer (∼ 680 s) than the conventional ferry event. Regarding the effects on beach sediment dynamics, the fast ferry waves were estimated to be very efficient in mobilising the nearshore sediments in contrast to those of the conventional ferry. The fast ferry service appears to generate daily prolonged nearshore events, which contain waves with higher energy than those expected from the normal summer wind wave regime of the area; these events also include some high and very steep waves, which can be particularly erosive. Therefore, fast ferry wakes may have considerable impacts on the seasonal beach sediment dynamics/morphodynamics and the nearshore benthic ecology, as well as they may pose significant risks to bathers, affecting the recreational use of the beaches exposed to fast ferry traffic. Finally, the study has shown that satisfactory field observations of the nearshore characteristics of ship-generated (and wind) waves can be obtained using inshore deployments of calibrated poles, digital video cameras and appropriate image processing algorithms.     

Low-frequency damping of a moored semisubmersible obtained from simulated extinction tests and mean wave drift forces

Low-frequency damping of a moored semisubmersible drilling platform was obtained from numerical extinction tests simulated in still water and in regular waves and from mean wave drift forces calculated at zero forward speed. The influence of drag forces was represented by the modified Morison equation. The platform as used for the 18th ITTC Comparative Mooring Study was analyzed in irregular beam waves. The computed time series of sway as well as the corresponding sway response spectrum compared favourably with model test measurements, demonstrating that this procedure to determine low-frequency damping can be effective.     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

Small-scale variability of zooplankton pyruvate kinase activity in the Gironde Estuary plume (Atlantic French Coast): A case study under unusually low freshwater discharge

Pyruvate kinase (PK) activity measurements are used to assess the role of carbohydrates in global feeding of mesozooplankton communities inhabiting an estuary plume. As a consequence of a remarkably low freshwater discharge rate, the sea surface layers of the area under estuarine influence showed a very moderate salinity fall and a nearly total depletion in nitrates, whereas higher levels of these nutrients were found in deeper, more saline, layers. Small-scale PK activity variations in mesozooplankton appear to be closely correlated to nitrate integration values within the water column. The results were analysed in comparison with literature reports. The study produced a coherent overall interpretation, which strongly supports the reliability of this new biochemical tool in detecting assimilation of trace carbohydrates in the diet of mesozooplankton.     

基于顶点度的多分辨率表示

针对边收缩算法在计算大曲率面距离公差时计算量大 ,且收缩大曲率面所含的线段时易使关键点发生偏移而引起模型变动过大、简化不够准确的问题 ,本文在边收缩算法基础上提出了加入顶点度控制的算法 ,以减少大曲率面距离公差的冗余计算 ,并提高模型简化质量。实验表明该算法能提高模型简化质量 ,并加快图形收缩的生成速度。     

基于圆特征的地图要素自动综合算法研究

分析了目前地图综合的地位、作用和发展情况,介绍了“优胜劣汰”思想,分析对比出自然界“优胜劣汰”基本思想和地图制图综合在某些方面存在共同的相似之处,从而尝试把它运用到地图制图综合中来,并结合Circle技术及其基本特点,提出了基于Circle原理和“优胜劣汰”思想的地图综合新算法,在地图综合的选取、化简、合并等方面得到了较好的应用,相应的例子在文中详细地进行了列举。