复方新诺明在罗氏沼虾中的药代动力学和组织分布

研究了单剂量肌肉注射给药[甲氧苄氨嘧啶(SMZ)0 60 mg/kg]、口灌给药[磺胺甲基异噁唑(SMZ)100 mg/kg]和复方口灌给药(SMZ 100 mg/kg和TMP 20 mg/kg)三种给药方式下,SMZ和TMP在罗氏沼虾中的代谢动力学,分析了SMZ和TMP血淋巴、肌肉和肝胰腺中的分布特征。结果表明,SMZ以肌肉注射方式给药后的血淋巴中,药物经时浓度曲线符合二室开放房室模型,而SMZ&TMP口灌给药后却不能用房室模型拟合。肌注给药后,SMZ的消除半衰期(t1/2β)为24.92 h,单方和复方口灌给药后SMZ的消除半衰期(t1/2β)分别为40.70和47.197 h。复方口灌给药后TMP的消除半衰期(t1/2β)为28.77 h,TMP对SMZ的药代动力学并无显著影响。口灌给药后,SMZ和TMP在肝胰腺中的药物浓度高于同时间肌肉中的药物浓度,但肌肉和肝胰腺中的SMZ消除速度基本一致。     

Results of recent Pacific-Arctic ice-ocean modeling studies at the Naval Postgraduate School

Summary of results from a high - resolution pan - Arctic ice - ocean model are presented for the northern North Pacific, Bering, Chukchi, and Beaufort seas. The main focus is on the mean circulation, communication from the Gulf of Alaska across the Bering Sea into the western Arctic Ocean and on mesoscale eddy activity within several important ecosystems. Model results from 1979 -2004 are compared to observations whenever possible. The high spatial model resolution at 1/12o （or -9 - km） in the horizontal and 45 levels in the vertical direction allows for representation of eddies with diameters as small as 36 km. However, we believe that upcoming new model integrations at even higher resolution will allow us to resolve even smaller eddies. This is especially important at the highest latitudes where the Rossby radius of deformation is as small as 10 km or less.     

Summer fast ice evolution off Zhongshan Station,Antarctica

Based on the field data acquired in the program of fast ice observation off Zhongshan Station, Prydz Bay, East Antarctica during the austral summer 2005/ 2006, physical properties evolution of fast ice during the ice ablation season is analyzed in detail. Results show that the annual maximum ice thickness in 2005 occurred in later November, and then ice started to reek, and the ablation duration was 62 days; sea water under the ice became warmer synchronously; corresponding to the warming sea ice temperature, a ＂relative cold mid-layer＂ appeared in sea ice; the fast ice marginal line recoiled back to the shore observably, and the recoil distance was 20.9 km from 18 December 2005 through 14 January 2006. In addition, based on the data of sea ice thickness survey along the investigation course of MV Xuelong on December 18 of 2005, the ice thickness distribution paten in the marginal ice zone have been described ： sea ice thickness increased, but the diversity of floe ice thick-ness decreased from open water to fast ice zone distinctly.     

闪光的青春——记叶县国土资源局规划股股长程冰

他一脸孩子气,却透着精明与干练,走起路来风风火火,办起业务老练利索。虽参加工作时间不长,却是局里上下公认的业务拔尖人才。     

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海平面上升速度超预测美国和丹麦新研究成果显示,世界第一大岛格陵兰岛积冰融化导致的全球海平面上升速度比原先预测要快得多。     

碎冰条件下单点系泊船舶动态响应特性研究

为了研究不同单点系泊位置对极地系泊船舶在来冰角度改变时动态响应的影响,运用离散元方法(DEM),计算了船舶在60%密集度下,冰速为1.0 m/s、冰厚为1 m时不同角度的船冰阻力,结合系泊分析软件二次开发功能,计算分析系泊船舶在不同来冰角度和不同系泊位置下受上述冰情影响下的响应。通过对模拟结果与试验结果的对比,认为离散元方法(DEM)的数值模拟结果与试验结果吻合较好;单点系泊位置为距船头L/4时,系泊船舶能以最快速、最稳定的方式对来冰方向的变化做出响应。     

《傅青主女科》理气药配伍应用浅析

《傅青主女科》理气药配伍应用于带下、血崩、调经、种子、妊娠、产后等各症之中。傅氏在其疾病治疗中注重气血的调理,妇人以血为主,以气为用,气机调畅,血海充盈则病自去。肝郁者,配以理气药,疏肝解郁又兼护肝血;湿邪为患者,配以理气药,气行则湿化;清热药配伍理气药,热毒得以解散;活血祛瘀药配伍理气药,气行则血行;补益药中配伍理气药,补而不滞,滋而不腻。     

周洁运用虫类药治疗肿瘤经验

介绍周洁教授运用虫类药治疗恶性肿瘤的经验。周教授临床常运用僵蚕、蝉蜕、蜂房、地龙、全蝎等虫类药,认为其具有祛邪引经和活血通络的功能,能够破血消癥、祛毒散结,对于恶性肿瘤患者的症状和生活质量具有较好的改善作用。但虫类药善于攻伐走窜,药性峻猛深入,虽攻毒散结效果显著,但或有毒性、或损伤气血、或中伤胃气,故使用应更加谨慎。因此,周教授在运用虫类药的同时注重配伍调养气血、顾护脾胃之品,临床效果显著。     

卢永屹运用花类药治疗黄褐斑经验

介绍卢永屹主任医师运用花类药治疗黄褐斑的经验。卢师认为黄褐斑的主要病机为肝郁、脾虚、肾亏,瘀血是其重要致病因素,临床上喜用花类药治疗,调畅气机、活血化瘀、安神助眠。     

桃红四物汤联合中医定向透药治疗骨质疏松椎体压缩性骨折术后疼痛30例

目的：观察桃红四物汤联合中医定向透药治疗骨质疏松型胸腰椎压缩性骨折（OVCF）维体成形术（PVP）术后疼痛的效果。方法：将60例OVCF患者随机分为2组,每组各30例。2组均行PVP术,术后均予常规护理,治疗组给予桃红四物汤联合中医定向透药治疗,对照组给予单纯中医定向透药治疗。采用疼痛视觉模拟评分（VAS）评价治疗前后2组患者的疼痛情况,采用功能障碍指数（ODI）评价治疗前后的功能障碍情况及优良率。结果：优良率治疗组为86.7%,对照组为53.3%,组间比较,差异有统计学意义（P＜0.05）;2组VAS评分、ODI评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义（P<0.05）。结论：OVCF患者术后应用桃红四物汤联合中医定向透药可明显减轻疼痛症状,具有较好的临床疗效。