基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

Estimation of runoff distribution within river systems: Application to the Lena Basin (Siberia)

A channel account approach is proposed to estimate longitudinal changes in runoff along large river systems. This new method provides a quantitative basis for describing the fluvial transport of suspended particulate material and dissolved substances. This method includes an evaluation of basic elements of water balance in separate sections of the river network and subsequent correction of channel accounting equations for the entire system using a maximum likelihood principle. To calculate water discharges of tributaries that have no hydrological information, structural analysis of river network is performed. This approach provides less error in comparison with traditional methods of estimating lateral inflow. The method is used to trace water discharge with increasing distance along the Lena river basin and to evaluate the contribution of geologically and lithologically uneven sub-basins in water discharge formation during a summer low water period.     

Modèles géostatistiques de concentrations ou de débits le long des cours d'eau

Estimating concentrations or flow rates along a stream network requires specific models. Two classes of models, recently proposed in the literature, are generalized, to the intrinsic case in particular. We present a global construction by ‘streams’, i.e. on the whole set of paths between sources and outlet. Combining stationary or intrinsic one-dimensional random functions leads to stationary or intrinsic models on segments, with discontinuities at the forks. A construction from outlet to sources, leads to stationary or intrinsic models on each stream, without any discontinuity at the forks. The linear variogram is found as a particular case. The extension to the linear model of coregionalization is immediate, allowing a multivariate modelling of concentrations. To cite this article: C. de Fouquet, C. Bernard-Michel, C. R. Geoscience 338 (2006).     

基于GIS的山地林道网优化配置系统

应用系统选择永安元沙国有林业采育场的部分林班为示范,建立森林资源空间数据库.以ARC/INFO为开发平台,以山地林道网理论为指导,应用G IS技术、DBMS技术与数学规划集成技术,使用AML语言进行二次开发设计山地林道网优化配置系统,实现计算机辅助林道网配置,提高决策的科学性。     

Statistical analysis for the hydrogeological evaluation of the fracture networks in hard rocks

The hydrogeological effectiveness of fracture sets is determined and evaluated by the fuzzy c-mean and hierarchical clustering. These cluster analyses combine the geological spatial attributes and the hydraulic relevant attributes of fractures. Based on the results of the clustering the fracture set volumes are estimated.     

小型水电站建设用地地质灾害评估技术研究——以湄尼多河小型水电站为例

现阶段,地质灾害评估技术人员在评估实践中,往往不注重各评估对象的差异性,采取同一评估模式,结果达不到评估的目的。在对小型水电站进行评估时,野外调查的重点,评估过程中所使用的方法以及危险性现状、预测及综合分区评估等与大型水电站、路线工程、矿山开采、民用建筑等工程有所不同。湄尼多河小型水电站工程位于云南省怒江州福贡县马吉乡境内,地质环境条件复杂,评估级别综合为二级。文章以该电站建设用地地质灾害危险性评估为例,对小型水电站建设用地地质灾害危险性评估的方法与理论进行探讨。     

河北省永久性GPS参考(网)站建立的研究与探讨

重点探讨了如何利用VRS技术在河北省区域内建立永久性参考站,如何进行数据的采集与管理,如何为GPS用户提供参考站数据等技术问题。     

中国深空测控网建立方案的研究

概述了深空测控网的基本技术要求,总结了我国卫星测控网和国内现有射电观测设施的技术、组成和分布,分析和论述了将我国现有的测控设施建设成深空测控网的具体方案。     

基于全站仪的圆形建筑物倾斜观测的方法和精度

随着建筑物的不断增高、增大,其稳定性和可靠性成为人们关注的焦点.其中建筑物的倾斜度是衡量施工技术质量的重要指标之一.而传统的观测方法如经纬仪测小角法、经纬仪投点法,由于受仪器精度和观测条件的限制,观测精度较低.拓普康全站仪独具推出的圆柱偏心测量功能为快速、准确测定圆形建筑物的倾斜量开辟了一条新途径,本文阐述了基于全站仪的圆形建筑物倾斜观测的原理和方法,并对其精度进行分析.     

自由测站法曲线座标计算程序设计

通过对曲线测设和测点坐标计算过程的分析，把坐标计算的程序设计归结为有向直线与X轴顺时针夹角即方位角的计算和线路转向转角的计算，弥补了测点位置和计算公式分类复杂等不足，简化了程序设计和计算过程。