基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

论南岭成矿带大宝山斑岩型铜矿的特殊性及其勘查意义

广东省大宝山矿床是南岭成矿带唯一的大型铜多金属矿床，此次研究在矿区中南部发现了细脉浸染状铜矿的新类型。为确定其是否为斑岩型铜矿的成因类型，本文在梳理南岭成矿带铜成矿条件和成矿规律的基础上，查明了矿区中南部英安斑岩的蚀变和铜矿化特征。综合研究认为南岭成矿带早侏罗世中酸性斑岩的小岩体较多，叠加多期断裂构造和碳酸盐岩建造，非常有利于铜多金属成矿物质的运移、富集。大宝山英安斑岩发育黑云母化、钾长石化、青磐岩化、绢英岩化、泥化等蚀变类型，铜矿化与绢英岩化、绿泥石化关系密切。大宝山铜矿中的英安斑岩沿逆冲推覆构造侵位并呈岩墙状产出，冷却过程中受区域构造应力产生了一组平行裂隙，岩浆房去气作用排出的热液沿裂隙蚀变围岩并充填成矿。大宝山斑岩型铜矿取得的找矿勘查成果表明，“全位成矿，缺位找矿”理念可以有效指导靶区圈定和老矿山外围（深部）找矿勘查，早侏罗世的南岭具有形成较大规模斑岩型铜矿的条件。     

张广才岭南部杨木岗组的厘定及物源分析

本文通过岩石组合特征和区域对比，将张广才岭南部西蛤拉河子—大锅盔一带分布的浅变质地层重新厘定为杨木岗组。为了确定杨木岗组的形成时代和沉积物源，进行了碎屑锆石U- Pb年代学和微体古生物地层学研究。锆石大多数呈自形—半自形晶，显示典型振荡岩浆生长环带，暗示其岩浆成因。该地层中测得的两组碎屑锆石U- Pb产生多组谐和年龄，其中PM010- TW样品56个测点最小峰值(谐和)年龄为307 Ma，DB02- TW样品51个测点最小峰值(谐和)年龄为275 Ma；覆盖在杨木岗组之上的中生代二浪河组安山岩的定年结果为181. 1±0. 9 Ma，表明杨木岗组形成于早二叠世晚期。杨木岗组中获取疑源类化石组合出现了新元古代晚期—早寒武世和奥陶纪地层常见分子，结合碎屑锆石年龄结果，反映杨木岗组沉积时周围存在早古生代和中—新元古代地质体。碎屑沉积岩Al2O3/TiO2平均值为24. 44，稀土元素球粒陨石标准化曲线具有轻稀土富集、重稀土稳定和负Eu异常特征，结合碎屑锆石的年龄频数可以看出，确定杨木岗组的沉积物主要来源于沉积盆地周围的晚古生代早期中酸性火成岩，次要物源由沉积盆地周边的早古生代地质体和近地表的中—新元古代地质体提供。佳木斯地块为松嫩- 张广才岭地块上晚古生代地层的形成提供了部分物源，暗示佳木斯地块与松嫩- 张广才岭地块于早二叠世之前已完成拼合。     

珠江口盆地西江主洼油气差异分布机制

西江主洼是珠江口盆地一个低勘探程度洼陷，油气差异聚集特征明显，但其机理不清。本文在断陷盆地油气成藏理论指导下，利用研究区地质、地球物理和地球化学等资料，开展了烃源岩、断盖组合、储集体系和运聚模式等方面的研究。结果表明，裂陷期沉降、沉积中心有序迁移，造成主力烃源岩自东向西由文四段迁移至文三段、文一+二段，控制东、西部油气差异分布。恩平组区域性泥岩发育且晚期断裂缺乏，导致油气纵向上更易聚集于下构造层；区域泥岩减薄尖灭或晚期断裂切开盖层的区域，上构造层有一定油气分布。"源-汇"类型从宏观上控制储层优劣，影响下构造层油气富集程度；"仓储"运移是控制上构造层油气规模聚集的主要模式。下构造层古近系应作为重点部署方向，东部围绕文四段、西部围绕文三段、文一+二段烃源岩构成的含油气系统展开；上构造层勘探需关注珠海组，在隆起周边寻找具备"仓储"运移模式的有利区带。     

船式支护在基坑中的应用

在深厚软土地区的基坑,对基坑底软土进行搅拌加固形成强度较高的底板而保证坑底稳定,侧壁采用支护桩支护保证侧壁的稳定使其不倾倒,支护桩与加固底板两者共同作用形成的船状结构支护体系类似轮船的船侧壁及船底板,以保证基坑的稳定。结合具体的工程实例,介绍了船式支护的侧壁及底板的设计方法。工程案例成功实施,监测结果表明,船式支护既可避免支护桩嵌固深度过长,又利于软土的土方施工及工程桩的保护,是安全可靠的,对类似工程有一定的参考意义。     

杨山晚古生代沉积盆地成因类型及其与桐柏-大别造山带关系的探讨

杨山晚古生代沉积盆地位于桐柏-大别山北麓,它具有明显的前陆盆地沉积特点,由早期(D₂?—C₁)的复理石建造到晚期(C₁—P?)的磨拉石建造;古生物地理分析表明其与华北、扬子陆块都有密不可分的联系,其间不可能有古洋盆的存在,因而它应当是桐柏一大别造山带碰撞造山过程中形成的前陆盆地。杨山晚古生代前陆盆地的形成说明,扬子陆块和华北陆块的陆-陆碰撞起始于晚泥盆世之前(S₃—D₂),而桐柏-大别造山带中生代的构造事件则可能代表一次大规模陆内逆冲-推覆作用。     

Research on temporal and spatial distribution, evolutionary character and mechanism of crustal deformation field before and after the Tangshan earthquake

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The Ms = 6.2, June 15, 1995 Aigion earthquake (Greece): evidence for low angle normal faulting in the Corinth rift

We present the results of a multidisciplinary study of the M_s = 6.2, 1995, June 15, Aigion earthquake (Gulf of Corinth, Greece). In order to constrain the rupture geometry, we used all available data from seismology (local, regional and teleseismic records of the mainshock and of aftershocks), geodesy (GPS and SAR interferometry), and tectonics. Part of these data were obtained during a postseismic field study consisting of the surveying of 24 GPS points, the temporary installation of 20 digital seismometers, and a detailed field investigation for surface fault break. The Aigion fault was the only fault onland which showed detectable breaks (< 4 cm). We relocated the mainshock hypocenter at 10 km in depth, 38 ° 21.7 N, 22 ° 12.0 E, about 15 km NNE to the damaged city of Aigion. The modeling of teleseismic P and SH waves provides a seismic moment M_o = 3.4 10¹⁸ N.m, a well constrained focal mechanism (strike 277 °, dip 33 °, rake – 77°), at a centroidal depth of 7.2 km, consistent with the NEIC and the revised Harvard determinations. It thus involved almost pure normal faulting in agreement with the tectonics of the Gulf. The horizontal GPS displacements corrected for the opening of the gulf (1.5 cm/year) show a well-resolved 7 cm northward motion above the hypocenter, which eliminates the possibility of a steep, south-dipping fault plane. Fitting the S-wave polarization at SERG, 10 km from the epicenter, with a 33° northward dipping plane implies a hypocentral depth greater than 10 km. The north dipping fault plane provides a poor fit to the GPS data at the southern points when a homogeneous elastic half-space is considered: the best fit geodetic model is obtained for a fault shallower by 2 km, assuming the same dip. We show with a two-dimensional model that this depth difference is probably due to the distorting effect of the shallow, low-rigidity sediments of the gulf and of its edges. The best-fit fault model, with dimensions 9 km E–W and 15 km along dip, and a 0.87 m uniform slip, fits InSAR data covering the time of the earthquake. The fault is located about 10 km east-northeast to the Aigion fault, whose surface breaks thus appears as secondary features. The rupture lasted 4 to 5 s, propagating southward and upward on a fault probably outcropping offshore, near the southern edge of the gulf. In the shallowest 4 km, the slip – if any – has not exceeded about 30 cm. This geometry implies a large directivity effect in Aigion, in agreement with the accelerogram aig which shows a short duration (2 s) and a large amplitude (0.5 g) of the direct S acceleration. This unusual low-angle normal faulting may have been favoured by a low-friction, high pore pressure fault zone, or by a rotation of the stress directions due to the possible dip towards the south of the brittle-ductile transition zone. This fault cannot be responsible for the long term topography of the rift, which is controlled by larger normal faults with larger dip angles, implying either a seldom, or a more recently started activity of such low angle faults in the central part of the rift.     

参数的期望估计及其在形变分析中的应用

利用“参数的期望估计”能准确定位、定量粗差及参数的期望估计不受粗差影响折特殊性质,寻找地壳变形区域和不变形区域,以确定拟稳点,进而进行拟稳变换,分析地菜变,将是一种有效方法。     

四川木里耳泽岩溶型金矿床形成条件和成矿机制

四川本里耳泽金-菱铁矿建造矿床,赋存于上二叠统海相碳酸盐岩层中,矿化受古岩溶的严格控制,组成矿石的基本矿物为菱铁矿,金不均匀地分布于菱铁矿矿体内。成矿溶液来自加热的循环地下水。成矿过程分为早阶段和中-晚阶段。成矿温度为156-210℃,成矿深度小于1km.成矿物质主要来自地层。成矿热液呈碱性和弱还原性,贫硫,含中等盐度。矿床形成时的地质构造环境较稳定。这是我国仅见的一种特殊金矿类型。