基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

On the variational approach to the periodic n-body problem

This expository paper gathers some of the results obtained by the author in recent works in collaboration with Davide Ferrario and Vivina Barutello, focusing on the periodic n-body problem from the perspective of the calculus of variations and minimax theory. These researches were aimed at developing a systematic variational approach to the equivariant periodic n-body problem in the two and three-dimensional space. The purpose of this paper is to expose the main problems and achievements of this approach. The material here was exposed in the talk that given at the Meeting CELMEC IV promoted by SIMCA (Società italiana di Meccanica Celeste).     

集群产业优势对区域品牌形成的作用机理研究——以温州典型产业集群为例

为了获得集群产业优势与区域品牌形成之间的作用机理,在回顾大量相关文献的基础上,从理论层面推导出集群产业优势的构成维度;通过对温州集群品牌的深访研究,获得维度构成和测量指标,印证和修正理论模型,开发量表和设计问卷;并以温州典型产业集群为例,对影响区域品牌形成的集群产业优势进行实证研究。结论证实集群产业优势的4个维度(成本优势、产品优势、创新优势和营销优势)对区域品牌形成均具有显著作用。     

Developing and Sequencing Community Engagement and Experiential Education: A Case Study of Urban Geography Teaching and Research

Community engagement curricula and course design can provide substantial experiences for both community members and participating students. Using a case study approach, this research focuses on four steps in this process: initial community relationship forming, engaging in community service, transitioning to civic engagement, and developing a community-based research program. Narrative examples from student course evaluations position these community-based experiences as transformative for multiple parties. Institutional structures are presented as helpful entrees to engagement for students, while noting that community relationships provide contextualized, powerful, and meaningful relationships, supporting recommendations for emerging and existing community engagement programs.     

Further examples of ventifacts and unusual patterned ground from the Falkland Islands, South Atlantic

Abstract Examples of ventifacts and forms of unusual patterned ground that differ in situation, characteristics and/or origin to types reported previously are described from the Falkland Islands, South Atlantic. The ventifacts, represented by clasts projecting from an eroding tillite shore platform, have been grooved by the passage of windblown sand. The patterned ground forms comprise stone polygons on clay loam regolith, stone polygons on peat, peat‐filled desiccation cracks on peat, and clusters of on‐edge clasts (stone packings) on a gravel beach. Aeolian transport of particles is considered responsible for the infill of the polygonal cracks. The clusters of on‐edge clasts are thought to have developed as a result of wave action, in particular backwash and/or undertow. Although these features occupy small surface areas they provide useful information about local geomorphic processes and testify to the marked diversity of such features in nature.     

基于水库调蓄的黄河干流水体交换时间研究(英文)

This note analyzes the change in water renewal time characteristics based on res-ervoir action and then establishes calculation models for the water renewal time in the Yellow River mainstream. The results indicate that the amount of renewable water with reservoir action can meet the annual water demand and that water flows naturally at the Lijin station near estuary. Initial storage dynamics is an important factor in water resource renewable capacity at a certain time, and rational reservoir action can promote sustainable water re-source utilization. When the initial storages in the Longyang Gorge reservoir are 9.343 and 5.343 billion m3, the water renewal times are 28 and 33.9 d, respectively. Flow stoppage ap-pears in April and May.     

水流注入方式和填料层高度对人工湿地流态的影响

流态模拟实验作为评价人工净化湿地系统运行状况、物质在其中停留时间的有效工具,在污水处理领域具有重要作用。罗丹明B背景浓度低、重现性好,被选为评价升流式、降流式和填料层高度对水力流态影响的示踪剂。实验使用罗丹明B和NaCl作为示踪剂,在湿地系统中进行流态实验,探究升流式、降流式和填料层高度对人工净化湿地流态的影响。实验结果表明,升流式人工湿地比降流式人工湿地处理效果好,示踪剂水力停留时间(hydraulic retention time,HRT)的体积利用率分别为82.0%和76.8%,升流式人工湿地无效体积中死区占更大比例,而降流式人工湿地滞留区占无效体积的比例更大;人工湿地填料层高度对示踪剂停留时间分布影响不大,体积利用率都在80%以上,但是,其死区和滞留区随着填料层高度的变化在无效体积中所占的比例有所差异,死区所占的比例随着填料层高度的增加先增加后减少,滞留区所占的比例则先减少后增加。     

耐久性设计下水土腐蚀性评价体系的一种解决方案

水土腐蚀性评价标准与混凝土结构耐久性设计的防护标准是相互作用,相互影响的。本文通过2个地下水实例,比较了桩基础和地下室底板在不同规范体系下水土腐蚀性评价标准和防护标准的差异。腐蚀环境越严重,混凝土结构耐久性设计差异越大,因此,有必要统一水土腐蚀性评价标准和混凝土结构耐久性设计的防护标准。针对SO42-和CL-腐蚀性评价差异较大的情况,本文给出了干湿交替作用及其强度的定义,提出了一种统一水土腐蚀性评价指标及其分级的建议方案。干湿交替作用是指在固体表面能够形成液相水与气相水交替转换或持续转换的一种现象,干湿交替作用强度定义为固体表面液态水的相对蒸发速率和固体表层饱和度的乘积。     

简谐荷载下单层球面网壳动力失效机理研究

以具有实际工程意义的40m跨度K8型单层球面网壳为研究对象,采用ANSYS程序的Pipe20单元,考察不同矢跨比网壳在不同频率的简谐荷载作用下,随着荷载幅值的逐渐增大,其宏观和微观响应的变化,详细阐述了2类破坏行为的规律,并通过一定规模的参数分析,给出单层球面网壳动力强度破坏判别准则.