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1.
Advanced material constitutive models are used to describe complex soil behaviour. These models are often used in the solution of boundary value problems under general loading conditions. Users and developers of constitutive models need to methodically investigate the represented soil response under a wide range of loading conditions. This paper presents a systematic procedure for probing constitutive models. A general incremental strain probe, 6D hyperspherical strain probe (HSP), is introduced to examine rate‐independent model response under all possible strain loading conditions. Two special cases of HSP, the true triaxial strain probe (TTSP) and the plane‐strain strain probe (PSSP), are used to generate 3‐D objects that represent model stress response to probing. The TTSP, PSSP and general HSP procedures are demonstrated using elasto‐plastic models. The objects resulting from the probing procedure readily highlight important model characteristics including anisotropy, yielding, hardening, softening and failure. The PSSP procedure is applied to a Neural Network (NN) based constitutive model. It shows that this probing is especially useful in understanding NN constitutive models, which do not contain explicit functions for yield surface, hardening, or anisotropy. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
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LabVIEW设计中压力传感器的RBF神经网络温度补偿 总被引:5,自引:0,他引:5
在石油平台注水压力监测系统设计中 ,采用LabVIEW虚拟仪器平台 ,嵌入逼近能力强和收敛速度快的RBF神经网络 ,以人工环境实验数据为样本进行训练 ,实现了压力传感器的智能网络温度补偿。结果显示 ,此方法能够在压力、温度变化较大的恶劣环境下 ,获得很高的补偿精度。 相似文献
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目的:基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法:使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用(PPI)网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果:共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、丝氨酸/苏氨酸蛋白激酶1(AKT1)、白细胞介素-1B(IL-1B)等;主要涉及肿瘤坏死因子(TNF)、白细胞介素-17(IL-17)、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论:该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。 相似文献
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目的:基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法:应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体(GO)功能、京都基因与基因组百科全书(KEGG)通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果:筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1(JUN)、肿瘤坏死因子(TNF)、原癌基因(RELA)、干扰素γ(IFNG)、转化生长因子-β1(TGF-β1)等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论:青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。 相似文献
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L. J. TISON 《水文科学杂志》2013,58(1):5-8
Abstract A simple method is used to study the response of runoff in the Sahel to climate change. The statistical characteristics of rainfall are calculated over the western part of the Sahel for the period 1961–1990, using the BADOPLU network. Daily rainfall is simulated using a Markov process with Weibull distribution for rainfall depths. Runoff is modelled using a conceptual SCS model and the curve numbers are calculated for West Africa. Climate change is provided by simulations using the Arpège GCM (Scenario A1B), and a perturbation method is used on the parameters which describe the rainfall. Changes in rainfall are assumed to occur through increases in frequency, not intensity. Using Arpège, runoff is mainly found to increase, in depth and in number of events, by the end of the 21st century. Changes in evaporation and land use are not included in the analysis. The impact of this 21st century potential climate change (rainfall) on the runoff is found to be of the same magnitude as the impact of changes in land use. 相似文献
8.
Natural resource management and conservation programs that promote building capacity and social learning among participants often lead to the formation of learning networks: a type of social network where learning is both a goal and potential outcome of the network. Through forming relationships and sharing information, participants in a learning network build social capital that can help a network achieve social and environmental goals. In this study, we explored social capital in a learning network that emerged through a large-scale marine governance effort, the Coral Triangle Initiative on Coral Reefs, Fisheries, and Food Security. Through a mixture of social network analysis and key informant interviews, we examined the major patterns of information exchange among individuals who had participated in regional learning exchanges; evaluated whether the network's structure resulted in information sharing; and considered implications for strengthening network sustainability, capacity building, and learning. We found that the Regional Exchange network fostered information sharing among participants across national and organizational boundaries. While the network had individuals who were more central to information sharing, the network structure was generally decentralized, indicating potential resilience to changes in leadership and membership. Participants stressed the importance of the knowledge and connections they had acquired through the learning network; however, they expressed doubts regarding its sustainability and stressed the need for a strong coordinating entity. Our findings suggest that conservation learning networks have the ability to bridge cultural divides and promote social learning; however, a strong network coordinator and continuing efforts to support information sharing and learning are crucial to the network's strength and sustainability. The tangible learning and capacity development outcomes cultivated through Regional Exchange network underscore the value of and need to invest in conservation networks that support peer-to-peer learning. 相似文献
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