基于数据挖掘分析中药复方治疗肺癌伴恶性胸腔积液的用药规律

目的：运用中医传承计算平台（V3.0）分析中医药治疗肺癌伴恶性胸腔积液的用药规律。方法：计算机检索2000年1月1日至2022年2月28日中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）中关于中药复方治疗肺癌伴恶性胸腔积液的文献,分析中药的性味归经、功效、频次、药物组合、关联规则及聚类等。结果：共纳入文献98篇,处方103首,中药197味。频次≥20次的中药有18味,排前10位的依次为葶苈子、茯苓、白术、黄芪、大枣、甘草、泽泻、桂枝、半夏、薏苡仁。四气以寒、温、平为主;五味以甘、苦、辛为主;归经以肺、脾、胃经为主。排前3位的功效依次为补虚、利水渗湿、化痰止咳平喘。用药频次≥20次的中药组合有37组,排前4位的依次为茯苓-葶苈子、白术-茯苓、茯苓-黄芪、大枣-葶苈子。支持度≥25%的核心药物为黄芪、白术、茯苓、甘草、葶苈子、大枣、桂枝、泽泻。中药聚类分析提取到4个核心组合。结论：肺癌伴恶性胸腔积液多属晚期,以气血阴阳俱虚为本,饮停胸胁为标,病机多虚实夹杂。中医药治疗此病多以甘温益气补虚治本,苦寒泻肺利水治标,同时兼以温阳化气。     

基于数据挖掘探讨中药治疗肝豆状核变性的用药规律

目的：基于数据挖掘探讨中药治疗肝豆状核变性的用药规律。方法：计算机检索1990年1月至2020年1月中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）中中药治疗肝豆状核变性的相关文献,利用Microsoft Excel 2010 进行频次分析,通过 SPSS Modeler 18.0、SPSS Statistics 23.0 对处方药物进行关联规则、复杂网络、系统聚类分析。结果：最终纳入文献161篇,筛选出处方151首,中药70味。中药频次排前5位的依次是泽泻、姜黄、大黄、黄连、丹参;功效排前5位的依次是利水渗湿、活血化瘀、清热、补虚、泻下药。二项关联多为利水渗湿、活血化瘀、清热、泻下药的组合,三项关联多为活血化瘀、清热、利水渗湿药的组合。聚类分析得到新方聚类的中药组合3类。结论：中医药治疗肝豆状核变性以清热化湿、活血化瘀为主,常用利水渗湿、活血化瘀、清热药,可配伍补虚及泻下药等。     

协同多时相波谱特征的不透水面信息级联提取

不透水面作为反应城市表征变化和区域城镇化的重要技术指标,其位置、图斑大小、空间分布等信息在地表水热循环和能量平衡等领域被广泛需求。传统方法大都基于单一时相信息提取不透水面,而忽略多时相所蕴含的丰富信息。因此,本文提出多时相信息融合的不透水面级联提取方法,利用Landsat-8 OLI遥感影像分析归一化植被指数（Normalized Difference Vegetation Index, NDVI）、改进的归一化水体指数（Modified Normalized Difference Water Index, MNDWI）和归一化建筑指数（Normalized Difference Building Index, NDBI）年内时序变化特点和典型地物间多时相波谱曲线的协同特征,并归纳不透水面多时相变化规律;再根据先验知识所获取的有效地表信息,进行多时相分级提取不透水面信息。此外,基于实地考察数据和同期2 m GF-1遥感影像屏幕数字化生成30 m不透水面图斑,进行精度验证、分析和对比单时相、四季相及多时相3种时序情况下的提取精度。结果表明：单时相提取不透水面总精度最低,四季相提取精度优于单时相,而多时相提取精度最高（精度可达93.66%,Kappa系数为0.81）。本方法在偏远城镇不透水面的有效识别中显露潜在优势,可为不透水面提取方法融合时序波谱特征提供新思路。     

The Value of Practice-Based Knowledge

Increasing recognition of the value of practice-based or experiential knowledge in natural resource management justifies the creation of a new category of articles in Society & Natural Resources that we are calling Practice-Based Knowledge (PBK). The rationale for focusing on PBK is due to its key role in the emergence of hybrid governance institutions across state, market, and civil society, understanding the complexity of dynamic socioecological systems, recognizing the challenges of multiple knowledge systems and context-specific practices, embracing the power of informal institutions and civic science, and engaging debates on the growing prevalence of market-oriented conservation. The goal is to provide a dedicated space within the published, peer-reviewed literature for scholars, government officials, nonprofit managers, and engaged citizens to share experiences informed by practical action. Relevant and timely practice-based insights may improve understanding and management of social and ecological processes and systems, while also offering the potential to contribute to theory.     

In Situ Maintenance of Traditional Ecological Knowledge on Malekula Island,Vanuatu

Traditional ecological knowledge (TEK) guides resource management across the globe, but is at risk amid social and ecological change. This has prompted numerous calls for TEK maintenance efforts, but these remain largely unexamined in the literature. Here, we discuss three examples of in situ TEK maintenance from Malekula Island in Vanuatu, locally known as kastom schools. Based on qualitative data, we find that the kastom schools may create several opportunities to maintain TEK (e.g., establishing local control over education), and argue that they represent the creative and adaptive management of tradition in dynamic social–ecological contexts. However, a number of challenges, both practical (e.g., lack of funding) and epistemological (e.g., changing modes of cultural transmission), threaten the efficacy of the kastom schools. We argue that in situ modes of TEK maintenance have promise, but that issues of power and heterogeneity require serious consideration if such measures are to succeed.     

Modeling and representation for earthquake emergency response knowledge: perspective for working with geo-ontology

Earthquake emergency response is one of the three earthquake disaster mitigation work systems in China, already achieving good results in some earthquake disaster mitigation situations. Earthquake emergency plans and emergency command systems are among the most important research and operations components of emergency response. These components commonly come with challenges, such as the pertinence of emergency commands and the operability of the countermeasures to be improved. The promise for solving this problem resides with applying knowledge that aids intelligence creation for decision-making. In this paper, we put forward a conceptual model of knowledge for earthquake disaster emergency response (EDER); compositions of EDER knowledge are introduced within architecture. A modeling method incorporating geo-ontology is used to build basic modeling primitives. Geo-ontology serves to represent geospatial characteristics of the EDER knowledge and addresses a need for semantic interoperability in the modeling process. A decision problem framework and a case study have been used as theoretical framework and an application test, respectively, to evaluate the EDER knowledge architecture and models. The EDER knowledge model provides a foundation for intelligent emergency response that helps solve knowledge problems to improve earthquake disaster response.     

Making a Mark: a computational and visual analysis of one researcher’s intellectual domain

Dr. David Mark is widely regarded as a path-breaking researcher in geographic information science. What are the structural and temporal characteristics of his intellectual contributions, as seen through the eyes of the broader academic community? Aiming to answer that question, this article presents a scientometric analysis of publications that have been cited alongside David Mark’s papers. In deliberate contrast to the widespread focus on using citation data to condense scientific impact into a handful of indicators, the methodological contribution of this study lies in its mix of computational and visualization approaches. In the search for latent domain structures, state-of-the-art practices in information science, bibliometrics, and network visualization are combined and extended. An initial network of 50,000+ publications and 4,000,000+ document co-citations undergoes a series of transformations reducing it to 9000 publications that are then clustered in a two-stage process, leading to 678 communities whose co-citation linkages are used to delineate 19 super-communities. To enable replication of this approach for other studies, much focus in this article is on detailed discussion of that workflow as well as on highlighting the reasoning behind the choices made among data sources and analytical methods. The topical evolution of David Mark’s domain of influence is explored in some detail, based on tabular and graphic representations of extracted community structures. Results confirm not only the enormous overall breadth of his influence but also how lasting and recurrent it has been in some areas.     

Evaluation of Three Harvest Control Rules for Bigeye Tuna（Thunnus obesus） Fisheries in the Indian Ocean

The stock of Bigeye tuna（Thunnus obesus） in the Indian Ocean supports an important international fishery and is considered to be fully exploited. The responsible management agency, the Indian Ocean Tuna Commission（IOTC）, does not have an explicit management decision-making framework in place to prevent over-fishing. In this study, we evaluated three harvest control rules, i） constant fishing mortality（CF）, from 0.2 to 0.6, ii） constant catch（CC）, from 60000 to 140000 t, and iii） constant escapement（CE）, from 0.3 to 0.7. The population dynamics simulated by the operating model was based on the most recent stock assessment using Stock Synthesis version Ⅲ（SS3）. Three simulation scenarios（low, medium and high productivity） were designed to cover possible uncertainty in the stock assessment and biological parameters. Performances of three harvest control rules were compared on the basis of three management objectives（over 3, 10 and 25 years）： i） the probability of maintaining spawning stock biomass above a level that can sustain maximum sustainable yield（MSY） on average, ii） the probability of achieving average catches between 0.8 MSY and 1.0 MSY, and iii） inter-annual variability in catches. The constant escapement strategy（CE=0.5）, constant fishing mortality strategy（F=0.4） and constant catch（CC=80000） were the most rational among the respective management scenarios. It is concluded that the short-term annual catch is suggested at 80000 t, and the potential total allowable catch for a stable yield could be set at 120000 t once the stock had recovered successfully. All the strategies considered in this study to achieve a ‘tolerable＇ balance between resource conservation and utilization have been based around the management objectives of the IOTC.     

Evaluation of three harvest control rules for Bigeye Tuna (Thunnus obesus) fisheries in the Indian Ocean

The stock of Bigeye tuna(Thunnus obesus) in the Indian Ocean supports an important international fishery and is considered to be fully exploited. The responsible management agency, the Indian Ocean Tuna Commission(IOTC), does not have an explicit management decision-making framework in place to prevent over-fishing. In this study, we evaluated three harvest control rules, i) constant fishing mortality(CF), from 0.2 to 0.6, ii) constant catch(CC), from 60000 to 140000 t, and iii) constant escapement(CE), from 0.3 to 0.7. The population dynamics simulated by the operating model was based on the most recent stock assessment using Stock Synthesis version Ⅲ(SS3). Three simulation scenarios(low, medium and high productivity) were designed to cover possible uncertainty in the stock assessment and biological parameters. Performances of three harvest control rules were compared on the basis of three management objectives(over 3, 10 and 25 years): i) the probability of maintaining spawning stock biomass above a level that can sustain maximum sustainable yield(MSY) on average, ii) the probability of achieving average catches between 0.8 MSY and 1.0 MSY, and iii) inter-annual variability in catches. The constant escapement strategy(CE=0.5), constant fishing mortality strategy(F=0.4) and constant catch(CC=80000) were the most rational among the respective management scenarios. It is concluded that the short-term annual catch is suggested at 80000 t, and the potential total allowable catch for a stable yield could be set at 120000 t once the stock had recovered successfully. All the strategies considered in this study to achieve a ‘tolerable' balance between resource conservation and utilization have been based around the management objectives of the IOTC.     

构造地理要素趋势面的尺度转换普适性方法探讨

当前的遥感科学面临着遥感数据获取能力与数据应用能力之间突出的供需矛盾。尺度问题作为遥感科学中的关键问题,既限制了遥感作为一门科学向系统性、普适性的发展,又限制了遥感应用能力的发展。本文对定量遥感中的尺度问题进行了梳理,包括:遥感与传统站点观测之间的不一致、不同尺度遥感产品之间的不一致、机理模型的尺度适用问题,以及遥感产品与用户需求时空尺度间的不一致。对遥感中的尺度转换方法展开了讨论,总结了尺度转换的关键问题在于原数据信息量不足时引入额外信息和保留关键信息两方面。提出了构造地理要素趋势面的基本构想,搭建了一个具有普适性的尺度转换方法框架。核心内容是充分利用地表环境要素时间、空间上的信息作为先验知识,通过关联遥感观测新信息和先验趋势面生成指定时空尺度的地表要素产品。