基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

城市建设中的地震小区划与浅层地震探测

简要阐述地震小区划在现代城市建设中的重要性以及在实施地震小区划的研究中浅层地震探测的重要作用及其方法原理,并给出应用浅层地震探测在城市地震小区划中的实例。     

关于修改港工钢筋混凝土规范小偏心受压构件正截面强度计算的建议

本文提出在小偏心受压构件正截面强度计算中，取消弯曲抗压强度ｆｃｍ（Ｒｗ），采用轴心抗压强度ｆｃ，这与构件的实际破坏形态相符。对小偏心受压构件正截面强度计算提出了设计建议。特别是对工程上大量应用的矩形截面对称配筋小偏压构件提示了简捷的设计方法，与以往的近似计算方法相比具有物理概念明确，精度高，方法简捷的特点。     

Species and Distribution of Mangroves in the Fujian Coastal Area

On the basis of an investigation on the mangroves in Fujian from November 1998 to January 1999, the species composition, area, distribution, artificial afforestation of mangroves and the factors restricting the development of mangroves in Fujian are discussed in the paper. Some suggestions on how to develop mangroves in Fujian have been put forward.     

Hydrography and phytoplankton of waters off south-west Ireland

Distributions of physical, chemical and biological characteristics were recorded for coastal waters off south-west Ireland during the summers of 1985–1987. A number of thermal fronts were identified from both shipboard measurements and satellite imagery. Upwelling was shown to be an important process in the area and enhanced phytoplankton biomass and productivity were associated with areas of upwelling and the fronts. Phytoplankton species composition, although varying between cruises, was associated with differences in hydrographic features.     

Regulation of Navigation Channel on Mouth Bar of Guanhe Estuary

-Based on the feasibility study of developing the navigation resources of the Guanhe River and the model test results of the mouth bar regulation, this paper presents some basic principles for the regulation of the channel on the mouth bar, for instance, the direction of navigation channel should be identical with that of the ebb tide current and the main waves, and perpendicular to the bathymetric contours. The principles for regulating mouth bars are also discussed in this paper.     

Distribution characteristics of zooplankton biomass in the East China Sea

On the basis of the data of oceanographic survey in the East China Sea in four seasons during 1997-2000 (23°30'~33°00'N, 118°30'-128°E), the variation of total biomass and diet biomass of zooplankton and their spatial-temporal distribution and relationship with the fishing ground of Engraulis japonicus are approached and analyzed. The results show that the average biomass is 65.32 mg/m3 in four seasons, autumn (86.18 mg/m3) being greater than summer (69.18 mg/m3) greater than spring (55.67 mg/m3) greater than winter (50.33 mg/m3). The average value of diet zooplankton biomass is 40.9 mg/m3. The trends of horizontal distribution both in the total biomass and the diet biomass of zooplankton are similar. The high biomass region (250-500 mg/m3) is very limited, only accounting for 1% of the investigation area. Seasonal variation of the biomass is very remarkable in the west and north parts of East China Sea coastal waters ( 29°30'N,125°E). The horizontal distribution of diet zooplankton depends on the     

东海XH凹陷烃资源预测──勘探层分析及石油资源专家系统分析

应用勘探层分析及石油资源专家系统对ＸＨ凹陷下第三系勘探目的层的三个勘探层烃资源量作出了综合预测，结果表明，凹陷内各勘探层，尤其是渐新统勘探层，烃资源量相当可观。提出在渐新统内的地层圈闭中可进一步作详细的勘探工作。     

高速摄影对散体振动的研究

以现代高速摄影技术和图像分析以及数据处理方法，针对高效振动磨机中弹性散体工质（如钢棒、球体等）的振动力学进行了深入的探讨和分析，为研究散体动力学和振动超细粉碎过程中的能量分布和传递规律以及能量与物质的相互转换机理奠定了基础，也为相关学科的发展提供了一种可以借鉴的方法。