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51.
52.
目的:基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法:使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用(PPI)网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果:共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、丝氨酸/苏氨酸蛋白激酶1(AKT1)、白细胞介素-1B(IL-1B)等;主要涉及肿瘤坏死因子(TNF)、白细胞介素-17(IL-17)、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论:该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。 相似文献
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将现代人工神经网络方法应用于地质学的判别分析,通过实例计算表明,无论是对于两组判别分析还是多组判别分析,人工神经网络方法都是切实可行的。 相似文献
55.
LI Hongwei TAN Jiahua Ph. D. Candidate School of Naval Architecture Ocean Engineering Shanghai Jiaotong University 《中国海洋工程》1998,(4)
This paper analyzes the pipe network system of oil-gas collection and transportation foroffshore oilfield development.A"0-1"integer linear programming model is constructed to optimize theinvestment of seabed pipe network.The mathematical model is solved by the spanning tree method ofgraph theory and network analysis.All spanning trees of a network graph compose all the feasible solu-tions of the mathematical model.The optimal solution of the model is the spanning tree with the minimumcost among all spanning trees.This method can be used to optimize the seabed pipe network system andgive a minimum cost plan for the development of offshore marginal oilfield groups. 相似文献
56.
Konstantin V. Lebedev Max Yaremchuk Humio Mitsudera Iwao Nakano Gang Yuan 《Journal of Oceanography》2003,59(6):751-763
A finite-difference quasigeostrophic (QG) model of an open ocean region has been employed to produce a dynamically constrained
synthesis of acoustic tomography and satellite altimetry data with in situ observations. The assimilation algorithm is based upon the 4D variational data interpolation scheme controlled by the model's
initial and boundary conditions. The data sets analyzed include direct and differential travel times measured at the array
of five acoustic transceivers deployed by JAMSTEC in the region of the Kuroshio Extension in 1997, Topex/Poseidon altimetry,
CTD soundings, and ADCP velocity profiles. The region monitored is located within the area 27.5°–36.5°N, 143°–155°. The results
of assimilation show that mesoscale variability can be effectively reconstructed by five transceivers measuring direct and
reciprocal travel times supported by relatively sparse in situ measurements. The misfits between model and data lie within the observational error bars for all the data types used in assimilation.
We have compared the results of assimilation with the statistical inversion of travel time data and analyzed energy balances
of the optimized model solution. Energy exchange between the depth-averaged and shear components of the observed currents
reveals a weak decay of the barotropic mode at the rate of 0.2 ± 0.7⋅10−5 cm2/s3 due to topographic interaction. Mean currents in the region are unstable with an estimate of the available potential energy
flux from the mean current to the eddies of 4.7 ± 2.3⋅10−5 cm2/s3. Kinetic energy transition has the same sign and is estimated as 2.8 ± 2.5⋅10−5 cm2/s3. Potential enstrophy is transferred to the mesoscale at a rate of 5.5 ± 2.7⋅10−18 s−3. These figures provide observational evidence of the properties of free geostrophic turbulence which were predicted by theory
and observed in numerical experiments.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
57.
58.
A strain of yeast, which can endure high osmotic pressure, is employed for the sensitive material of the microbial BOD sensor. Two immobilization methods are used, I.e. Calcium alginate gel be ads and PV A gel beads. The results show that the PVA gel beads is better. The influences of osmosis and heavy metal ions on the yeast entrapped in the PVA gel beads are also studied in the experiment. 相似文献
59.
Unlike in the open sea, the use of wind information for forecasting waves may encounter more ambiguous uncertainties in the coastal or harbor area due to the influence of complicated geometric configurations. Thus this paper attempts to forecast the waves based on learning the characteristics of observed waves, rather than the use of the wind information. This is reported in this paper by the application of the artificial neural network (ANN), in which the back-propagation algorithm is employed in the learning process for obtaining the desired results. This model evaluated the interconnection weights among multi-stations based on the previous short-term data, from which a time series of waves at a station can be generated for forecasting or data supplement based on using the neighbor stations data. Field data are used for testing the applicability of the ANN model. The results show that the ANN model performs well for both wave forecasting and data supplement when using a short-term observed wave data. 相似文献
60.
This paper reports a study of the field measurements and monitoring of wastewater discharge in sea water at Bari East (Italy). A wastewater sea outfall system is an integral and fundamental part of each wastewater treatment with ultimate sink in the sea water. The design of a water treatment plant and wastewater outfall must take into account the use of the environmental water, the values of physicochemical parameters to be respected in order to safeguard the use itself and the quality of the environmental water where wastewater is issued. In the present study measurements of sea current velocity components were carried out with a VM-ADP (Vessel-Mounted Acoustic Doppler Profiler). Salinity, wind directions and velocities were assessed with, for one survey, the total faecal coliforms and other biochemical parameters. It was emphasized that the measurements necessary for monitoring cannot be concentrated in the wastewater outfall pipe zone only, but should be extended to a neighbouring area of the outfall pipe, with an extension depending on the wastewater discharge, the polluting charge and the magnitude of the sea currents and the winds typical of the zone of interest. The analyses presented in this paper confirm that the sea zones close to the wastewater outfall pipe are particularly sensitive and vulnerable. Such results must be considered in the planning of a wastewater outfall pipe. 相似文献