Discrimination of sedimentary facies by association analysis

The ability of association analysis to discriminate sedimentary facies was tested on Purdy's modal analyses of modern sediments of the Great Bahama Bank. Purdy's data set has served in the past as a standard reference for evaluating various multivariate classification algorithms. In order to adapt Purdy's data to association analysis, the percent abundance of the 12 constituents was converted to binary form by dichotomizing each variable on its mean value. The results obtained by association analysis are virtually identical to those obtained by Purdy and other authors. The same four main sedimentary facies were discriminated; 86% of the samples were identically classified (97% when misclassified borderline cases are counted as matches); the total partition variance of the classification is only negligibly greater (4%); and the grouping of the variables yielded the same four groups. The rank order of the three division-attributes responsible for the sample classification is fines, oolites, and corals. Association analysis has been employed by other authors to differentiate meaningful facies groups in studies of ancient reef carbonates, modern reef sediments, and heavy minerals in stream sediments. In all these studies, the results were found to be compatible with those obtained by using the continuous quantitative measurements, indicating that qualitative binary data may often be sufficient for the purpose of facies discrimination in many branches of geology and that association analysis is an effective method for this purpose.     

The Statistical Analysis of Migration of Strong Earthquakes-Taking the North China Region as an Example

The migration of strong earthquakes is an important research topic because the migration phenomena reflect partly the seismic mechanism and involve the prediction of tendency of seismic activity. Research on migration of strong earthquakes has mostly focused on finding the phenomena. Some attempts on getting regularity were comparatively subjective. This paper suggests that there should be indices of migration in earthquake dataset and the indexes should have statistical meaning if there is regularity in the migration of strong earthquakes. In this study, three derivative attributes of migration, i.e., migration orientation, migration distance and migration time interval, were statistically analyzed. Results in the North China region show that the migration of strong earthquakes has statistical meaning. There is a dominant migration orientation (W by S to E by N), a dominant distance (≤100km and on the confines of 300～700km), and a dominant time interval (≤1a and on the confines of 3～4a). The results also show that the migration will differ slightly with different magnitude range or earthquake activity phase.     

电测深ρ＿s差值法的应用效果

用电测深研究地电断面、寻找隐伏多金属矿体时，以往采用ρ＿ｓ（或η＿ｓ）等值线断面图进行地质推断解释，因受浅源信号的干扰，效果差。本文提出了采用ρ＿ｓ（或η＿ｓ）差值法，能排除浅源干扰信号，反映出地电断面的相对变化，突出了深部微弱信息，取得了较好的地质解释效果。     

Design of stable drainage networks in upland forestry plantations

Erosion of man-made, forestry drainage channels occurs when the plough cuts through the surface peat layer into the underlying erodible mineral soil. A procedure is developed, based on hydraulic considerations, which will allow the drainage engineer to design stable drainage networks in upland forestry plantations. An example design chart is given for an erodible sandy loam type soil.     

宁远保安地区基性─超基性火山岩基本特征

本文论述了保安地区火山岩的地质、岩石、副矿物、岩石化学、微量元素、稀土元素、稳定同位素、火山岩相及火山机构等特征。并对其演化规律、形成机制与成矿作用的关系，作了初步探讨。     

Implications of low-pass filtering on power spectra and autocorrelation functions of turbulent velocity signals

Filtering either through the electronics of an instrument or through digital procedure is performed routinely on geophysical data. When velocity fluctuations are measured in turbulent flows using electromagnetic current meters (ECMs), a builtin lowpass Butterworth filter of order n usually attenuates fluctuations at high frequencies. However, the effects of this filter may not be acknowledged in turbulence studies, thus impeding comparisons between data collected with different ECMs. This paper explores the implications of the filters on the characteristics of velocity signals, mainly on variance, power spectra, and correlation analyses. Variance losses resulting from filtering can be important but will vary with the order n of the Butterworth filter, decreasing as n increases. Knowing the filter response, it is possible to reconstruct the original signal spectrum to evaluate the effect of filtering on variance and to allow comparisons between data collected with different instruments. The autocorrelation function also is affected by filtering which increases the value of the coefficients in the first lags, resulting in an overestimation of the integral length scale of coherent structures. These important effects add to those related to size and shape differences in ECM sensors and must be taken into account in comparative studies.     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

Freshening of the Intermediate Waters in the Northern South China Sea over the PastSix Decades

The properties of salinity in the South China Sea (SCS), a significant marginal sea connecting the Pacific andIndian Oceans, are greatly influenced by the transport of fresh water flux between the two oceans. However, the long-termchanges in the intermediate water in the SCS have not been thoroughly studied due to limited data, particularly in relationto its thermodynamic variations. This study utilized reanalysis data products to identify a 60-year trend of freshening in theintermediate waters of the northern South China Sea (NSCS), accompanied by an expansion of low-salinity water. Thestudy also constructed salinity budget terms, including advection and entrainment processes, and conducted an analysis ofthe salinity budget to understand the impacts of external and internal dynamic processes on the freshening trend of theintermediate water in the NSCS. The analysis revealed that the freshening in the northwest Pacific Ocean and theintensification of intrusion through the Luzon Strait at intermediate levels are the primary drivers of the salinity changes inthe NSCS. Additionally, a weakened trend in the intensity of vertical entrainment also contributes to the freshening in theNSCS. This study offers new insights into the understanding of regional deep sea changes in response to variations in boththermodynamics and oceanic dynamic processes.     

基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。