海藻硫酸多糖911对小鼠脾淋巴细胞增殖反应及对细胞产生IL—2作用的影响

本文以~3H—TdR掺入法观察911对小鼠脾淋巴细胞增殖反应的影响并用CTLL细胞检测了其对IL—2的作用。体外实验结果表明,911对小鼠脾淋巴细胞增殖反应有明显的增强作用,以0.5μg/ml的浓度效果最为明显,相对增殖指数RPI可达200％;体内实验则以5mg/kg体重ip,连续7d效果最好,相对增殖指数RPI可达176％;911用药组小鼠IL—2的产生量均高于对照组,以5mg/kg和10mg/kg效果最好。以上实验证明,这一多糖是一种有希望的新免疫调节药物。     

火山岩坡残积土地区暴雨滑坡泥石流的形成机理

暴雨条件诱发的浅层坡残积土质斜坡破坏的机理受控于土体在低有效围压条件下的应力应变特性。1993年11月4～5日,香港大屿山地区特大局部性暴雨导致在120km2范围内产生自然滑坡泥石流800余处,且绝大多数发生于火山岩风化坡残积土地区。本文对火山岩风化坡残积土开展了室内偏压固结不排水剪和偏压固结常剪应力排水剪试验,揭示了该类土的应力应变特性;在此基础上,分析了暴雨滑坡泥石流的形成机理和过程。     

Crustal motion and deformation in Greece from a decade of GPS measurements, 1993–2003

The Hellenic plate boundary region, located in the collision zone between the Nubian/Arabian and Eurasian lithospheric plates, is one of the seismo-tectonically most active areas of Europe. During the last 15 years, GPS measurements have been used to determine the crustal motion in the area of Greece with the aim to better understand the geodynamical processes of this region. An extended reoccupation network covering whole Greece has been measured periodically in numerous GPS campaigns since the late eighties, and a continuous GPS network has been operated in the region of the Ionian Sea since 1995. In this paper, we present a new detailed high-quality solution of continuous and campaign-type measurements acquired between 1993 and 2003. During the GPS processing, a special effort was made to obtain consistent results with highest possible accuracies and reliabilities. Data of 54 mainly European IGS and EUREF sites were included in the GPS processing in order to obtain results which are internally consistent with the European kinematic field and order to allow for a regional interpretation. After an overview of the results of the IGS/EUREF sites, the results from more than 80 stations in Greece are presented in terms of velocities, time series, trajectories and strain rates. Previous geodetic, geological and seismological findings are generally confirmed and substantially refined. New important results include the observation of deformation zones to the north and to the south of the North Aegean Trough and in the West Hellenic arc region, arc-parallel extension of about 19 mm/yr along the Hellenic arc, and compression between the Ionian islands and the Greek mainland. Due to continuous long-term observations of 4–8 years, it was possible to extract height changes from the GPS time series. In Greece, we observe a differential subsidence of the order of 2 mm/yr between the northern and central Ionian islands across the Kefalonia fault zone. The differential subsidence of the central Ionian islands with respect to the northwestern Greek mainland amounts to 4 mm/yr.     

Strain softening of K0-consolidated Changi sand under plane-strain conditions

Experimental results are presented in this paper to study the strain softening behaviour of a marine dredged sand under plane-strain conditions. K₀ consolidated drained and undrained tests were conducted using a new plane-strain apparatus to characterize the strain softening behaviour of the sand under plane-strain conditions. For medium dense specimens, strain softening and shear bands were observed to occur under both drained and undrained conditions. For very loose specimens, no shear bands were observed and critical states were reached within the homogeneous deformation region in both drained and undrained tests. Strain softening was observed to occur at small strain for very loose specimens under undrained conditions. Two types of strain softening, the homogenous softening and banding softening, were identified and the conditions for strain softening were established. The results obtained from this study were compared with the studies by Han and Vardoulakis (Géotechnique 41(1):49–78, 1991), Finno et al. (J Geotech Eng ASCE 122(6):462–473, 1996, Géotechnique 47(1):149–165, 1997) and Mokni and Desrues (Mech Cohes-Frict Mat 4:419–441, 1998).     

高采样率四分量钻孔应变同震响应分析

In this paper, we adopt the observation data of two 10Hz YRY 4-component borehole strainmeters and one 100Hz FBS-3B broadband seismometer to study the responses of their observations to the April 11, 2012 Mw 8.6 earthquake off the west coast of northern Sumatra, and compare the response characteristics during the coseismic stage after preprocessing of the data. We analyze the spectrum＇s dynamic process during the coseismic stage with the S transformation method, and discuss the spectrum＇s details in different seismic phases. The S transformation results of the data of seismometer and borehole strainmeter at the same station show that the coseismic spectrum evolution of the two kinds of observation are similar to each other and can be cross-referenced in indentifying the wave signals, which proves that the borehole strainmeter measurements at high frequencies are reliable.     

Probabilistic seismic response and reliability assessment of isolated bridges

Bridge seismic isolation strategy is based on the reduction of shear forces transmitted from the superstructure to the piers by two means: shifting natural period and earthquake input energy reduction by dissipation concentrated in protection devices. In this paper, a stochastic analysis of a simple isolated bridge model for different bridge and device parameters is conducted to assess the efficiency of this seismic protection strategy. To achieve this aim, a simple nonlinear softening constitutive law is adopted to model a wide range of isolation devices, characterized by only three essential mechanical parameters. As a consequence of the random nature of seismic motion, a probabilistic analysis is carried out and the time modulated Kanai-Tajimi stochastic process is adopted to represent the seismic action. The response covariance in the state space is obtained by solving the Lyapunov equation for a stochastic linearized system. After a sensitivity analysis, the failure probability referred to extreme displacement and the mean value of dissipated energy are assessed by using the introduced stochastic indices of seismic bridge protection efficiency. A parametric analysis for protective devices with different mechanical parameters is developed for a proper selection of parameters of isolation devices under different situations.     

多因素作用下石膏岩软化特性

为了研究隧道施工过程中石膏质围岩软化特性,以三叠系下统嘉陵江组地层中的石膏岩为研究对象,进行了多因素正交软化试验研究,分析了浸泡时间、溶液温度、 浓度对石膏岩软化后力学参数的影响规律。研究结果表明：石膏岩的软化系数和弹性模量随着浸泡时间的增加而减小,减小速率也随之降低;软化系数和弹性模量随溶液温度的升高而呈线性减小;在影响石膏岩软化后力学参数3个因素中浸泡时间的影响最大,权值高达80%,温度次之,权重为16%左右,而 浓度对石膏岩的软化影响非常微弱;建立了浸泡时间与溶液温度两个因素耦合作用下石膏岩软化后单轴抗压强度与弹性模量变化情况预测公式。在试验数据及结论的基础上从围岩坚硬程度划分、防排水措施及支护措施等方面提出了石膏围岩隧道的施工措施及建议。     

软岩的强度—变形—时间之间关系的试验分析

对软岩和有不连续面的软岩试样进行一系列固结不排水三轴压缩和蠕变试验,测定并分析了它们在正常固结和超固结状态下的应变软化性状、蠕变特性和残余强度的变化规律。探讨了软岩中存在的不连续面对应力－应变关系、残余强度特性和蠕变应变速率的影响。     

On the lag time between internal strain and basement involved thrust induced exhumation: The case of the Colombian Eastern Cordillera

Thrust sheets accumulate internal strain before they start moving along discrete fault planes. However, there are no previous studies evaluating the time difference between initiation of strain and fault displacement. In this paper we use observations from the Eastern Cordillera of Colombia to evaluate this interval. We utilize multiple thermochronometers and paleothermometers to refine the timing of deformation. Based on these new data we build time-temperature path estimates that together with geometric outcrop-based structural analysis and fluid inclusions allow us to assign relative timing to features associated with strain, such as cleavage, veins and certain types of fractures, and compare that with the timing of thrusting. We find that cleavage was only formed close to maximum paleotemperatures, almost coeval with the onset of thrust-induced denudation by the Late Oligocene. The corresponding structural level of fold-related veins suggest that they were formed later but still when the country rocks were at temperatures higher than 160 °C, mostly during the Early Miocene and still coexisted with the latest stages of cleavage formation. Our data show that the main period of strain hardening was short (probably a few million years) and occurred before first-order basement thrusting was dominant, but was associated with second-order folding.     

Calibration of the parameters for a hardening–softening constitutive model using genetic algorithms

The present paper introduces a genetic algorithm-based optimization technique to calibrate a nonlinear strain hardening–softening constitutive model for soils using five material parameters. The efficiency of the proposed technique is analyzed through the use of different GA techniques. The effects of elitism, crossover, and mutation, as well as population size, on the performance of the conventional GAs for this problem are investigated. Micro-genetic algorithms (mGAs) are chosen and tested for different population sizes. The mGAs with a population size of five yields the optimal parameter values after fewer function evaluations and capture the overall simulated or experimental behavior at every point in stress–strain and strain paths in triaxial compression. The proposed calibration technique is validated through comparison with the traditional calibration technique.