Evaluation of antitumor, immunomodulatory and free radical scavenging effects of a new herbal prescription seaweed complex preparation

Seaweed Complex Preparation (SCP) is a clinical traditional Chinese medicine preparation which is composed of seven traditional Chinese herbs, and it has been used for treatment of lung cancer, liver cancer and digestive cancer. However, little information is available about the pharmacodynamic basis. The antitumor, immunomodulatory and free radical scavenging effects of SCP were evaluated in this study. Transplanted tumor in vivo method was used to determine the antitumor effect. The effects on splenocyte proliferation and phagocytosis of macrophages in tumor-bearing mice were measured by the MTT method and the phagocytizing cock red blood cell (CRBC) method respectively. The scavenging activities of SCP on DPPH and hydroxyl radicals in vitro were investigated. It was found that the medium-dose and high-dose of SCP could significantly inhibit the growth of transplanted hepatic tumor of murine hepatocarcinoma cell line H22, and promote proliferation of splenocytes and phagocytosis of macrophages. SCP possessed noticeable scavenging activities on DPPH and hydroxyl radicals. The antitumor effects of SCP might be achieved by improving immune system and scavenging free radicals, which is in accordance with the viewpoint of traditional Chinese medicine in promoting the body resistance and eliminating pathogenic factors for cancer treatment.     

皱瘤海鞘神经递质和性类固醇激素含量与性腺发育成熟的关系

运用免疫组织化学和化学发光免疫分析方法研究了皱瘤海鞘(Styela plicata)神经递质多巴胺(DA)、5-羟色胺(5-HT)及其受体以及性类固醇激素含量与性腺发育成熟的关系.结果显示,DA和5-HT免疫活性定位在脑神经节中大小2种类型的神经细胞,DA免疫活性还定位在不同发育时期神经腺上皮细胞.5-HT受体免疫活性存在于脑神经节小型神经细胞和大生长期神经腺上皮细胞.在小生长期和大生长期性腺中均检测到DA、5-HT及其受体,提示DA和5-HT可能参与调节皱瘤海鞘的性腺发育.皱瘤海鞘为雌雄同体,化学发光免疫分析证实,海鞘性腺能够合成和分泌性类固醇激素,大生长期性腺中雄激素、孕激素和雌激素的含量分别为25.8±0.0、38.9±0.2和14.3±0.6pg/mg,提示性腺既是生殖组织也是内分泌组织.上述发现为证明尾索类海鞘可能像头索类文昌鱼一样,具有原始的生殖内分泌调控轴(脑神经节-神经腺-性腺)提供科学依据.     

大西洋中脊Logatchev热液区的地球物理场研究

利用"大洋一号"首次环球科考获得的地球物理资料,通过对多波束地形和地磁异常的解译,对大西洋Logatchev热液区的地球物理场特征进行了研究,研究结果表明 Logatchev热液喷口位于裂谷东侧的滑塌体上,处于南北地磁正负高值异常中心之间的缓冲带上,新发现的磁异常区与热液喷口区具有相似的特征,推测为未来的热液矿区。区内南西西-北东东和北-南向断裂不仅控制了基底深度和隆坳结构,也控制了超基性岩和热源磁性层的分布,因此它的形成与交叉切割的拆离断层、超基性岩、海洋核杂岩和重力滑塌有关。     

一种模态参数识别的虚假模态剔除技术

针对背景噪声下结构的模态参数识别结果存在虚假模态的情况,分析虚假模态产生的原因,通过理论推导提出辨别虚假模态的判断条件,根据判断条件剔除识别模态参数中包含的虚假模态。以比例阻尼海洋平台结构数值模型为例,在模拟噪声水平5%的工况下,获得结构脉冲响应信号,对基于奇异值分解定阶消噪后的信号用复指数法进行模态参数识别,对识别的模态频率和阻尼比进行虚假模态剔除。结果表明:根据判断条件可有效剔除所识别参数中的虚假模态。     

Comprehensive numerical analysis of fault‐structure systems – Computation of the large‐scale seismic structural response to a given earthquake scenario –

The seismic structural response is affected by temporal and spatial variations in strong ground motion. It can be evaluated through the fault‐structure system: the fault mechanism, wave propagation through the crust, amplification near the surface, and soil‐structure interaction. To analyze this system at high resolution and accuracy, we previously proposed a new multiscale analysis method and numerically verified its validity. However, the problem of the extremely large computation cost of constructing a three‐dimensional numerical model and solving the discretized governing equations still remains. Here, we introduce a new method to resolve these difficulties. By combining this new method with our multiscale analysis, we developed a tool for fault‐structure system analysis. The accuracy of this tool is verified by comparing it to a Green's function solution. Finally, we demonstrate the potential utility of the method by estimating the seismic response of a large and complex underground highway junction in a given earthquake scenario. Copyright © 2011 John Wiley & Sons, Ltd.     

瑞利波在复合地基检测中的应用

介绍瑞利波法的基本原理并结合武汉市江夏区某道路改扩建的工程实际,对其进行分析.     

Study on water saturation computation model in complex pore volcanic reservoir

Determination of water saturation is important for reservoir evaluation.When complex pore structures such as fracture and cavity are present in reservoir,Archie equation is no longer suitable.According...     

GEOMORPHIC AND STRATIGRAPHIC COMPLEXITY: HOLOCENE ALLUVIAL HISTORY OF UPPER WOLLOMBI BROOK, AUSTRALIA

Holocene and post‐European settlement alluvial histories of three nested drainage basins were reconstructed from detailed litho‐ and chronostratigraphy of cut and fill terraces and flood‐plains in the upper Wollombi Brook catchment. Fernances Creek (13.8 km²) valley fill consisted of intercalated thin mud sheets deposited in ephemeral swamps and thick sand sheets deposited by discontinuous channels. Dairy Arm (39.8 km²) valley fill was more complex, with inset alluvial fills in the upper basin and overlapping vertically stacked fills in the lower basin. However, correlative lithostrati‐graphic units were not found on all tributaries. Furthermore, basal radiocarbon dates on the last inset fill of four tributaries did not overlap, allowing for plus or minus twice the standard deviation of the reported ages. Wollombi Brook (341 km²) valley fill was also complex, with longitudinally discontinuous units, most of which were not found in the two tributaries. Upstream late Holocene channel incision was coeval with downstream chain of ponds because sediment generated by incision was stored in the intervening valley. Historical channel incision occurred between 1838 and 1867 on Fernances Creek at a locally steeper section of valley floor during the period of peak population and frequent floods immediately after a road crossing was constructed, but coincided with a catastrophic flood on Dairy Arm (June 1949) and on Wollombi Brook (1927). Lack of correlative litho‐ and chronostrati‐graphic units plus out‐of‐phase post‐European incision indicate that stratigraphic complexity is a function of geomorphic complexity due to the operation of geomorphic thresholds and complex response.     

叠前偏移技术在中原复杂断块区的应用

随着油气勘探开发的不断深入及相关学科的发展,复杂地质构造成像与地震岩性成像已成为急需解决的课题.针对中原复杂断块区地震资料的特点,对速度场的建立、叠前偏移中关键参数的选取以及偏移方法展开了深入细致的研究.通过叠前偏移技术在中原油田的应用,结果表明了该技术的有效性.     

论玄武岩底侵作用与长英质火成岩形成的关系--以华东南花岗质火山-侵入杂岩为例

地球层圈热结构特征表明,大陆地壳位于力学边界层（MBL）范围内,其热传递效应受地壳岩石热传导率制约。本文根据热传导理论,采用与前人相同的热物理参数,计算得出1200℃、500m厚玄武岩浆侵位于初始温度为500℃的地壳岩石中,由底侵作用引起地壳部分熔融产生的长英质岩浆（850℃）厚度≤250m,且产生长英质岩浆的时间限制在玄武岩侵位到地壳中后短暂的2700年内。江西南部龙南县临江地区中侏罗世余田群菖蒲组双峰式火山岩地质-地球化学特征及同位素年代学研究证实,该火山岩组合中的流纹质火山岩是拉班玄武质岩浆底侵作用的产物,符合上述数量比例和时间条件。我国东南部中生代陆壳（厚度≤50km）位于热传导起主导作用的MBL层内,由玄武岩浆底侵作用产生的长英质火成岩,在形成的时间及数量上应受地壳岩石热传导机制制约。但在我国东南部大面积出露的中生代火成岩中,花岗岩、流纹质火山岩类占90％以上,而玄武岩仅有局部零星分布,两者在数量上不匹配,在形成时间上也不一致,因而,我国东南部大面积出露的长英质火成岩可能并不是玄武岩浆底侵作用产物,其形成的热动力学背景和机制有待进一步研究。