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223.
探讨活性氧(reactive oxygen species,ROS)在温石棉激活线粒体通路诱导A549凋亡中的作用。采用不同浓度温石棉粉尘染毒人肺上皮细胞(A549)后,MTT法检测细胞存活率,流式细胞术检测ROS抑制剂N-乙酰半胱氨酸(N-acetyl-L-cysteine,NAC)预处理前后的细胞凋亡率、胞内ROS水平及线粒体膜电位,Western Blot法检测各组细胞半胱天冬氨酸蛋白酶3(caspase-3)、p53蛋白表达水平。实验结果显示,温石棉可降低A549细胞存活率,呈现时间-剂量效应关系;NAC可显著减少胞内ROS水平、阻止线粒体膜电位下降,并下调caspase-3、p53蛋白的表达水平,抑制部分细胞凋亡的发生。表明ROS可通过诱导p53蛋白过表达,激活线粒体凋亡通路,诱导A549细胞发生凋亡。 相似文献
224.
N.A. Gibsher A.A. Tomilenko A.M. Sazonov T.A. Bul’bak M.O. Khomenko M.A. Ryabukha E.O. Shaparenko S.A. Sil’yanov N.A. Nekrasova 《Russian Geology and Geophysics》2018,59(8):983-996
The Eldorado low-sulfide gold-quartz deposit, with gold reserves of more than 60 tons, is located in the damage zone of the Ishimba Fault in the Yenisei Ridge and is hosted by Riphean epidote-amphibolite metamorphic rocks (Sukhoi Pit Group). Orebodies occur in four roughly parallel heavily fractured zones where rocks were subject to metamorphism under stress and heat impacts. They consist of sulfide-bearing schists with veins of gray or milky-white quartz varieties. Gray quartz predominating in gold-bearing orebodies contains graphite and amorphous carbon identified by Raman spectroscopy; the contents of gold and amorphous carbon are in positive correlation. As inferred from thermobarometry, gas chromatography, gas chromatography-mass spectrometry, and Raman spectroscopy of fluid inclusions in sulfides, carbonates, and gray and white quartz, gold mineralization formed under the effect of reduced H2O-CO2-HC fluids with temperatures of 180 to 490 °C, salinity of 9 to 22 wt.% NaCl equiv, and pressures of 0.1 to 2.3 kbar. Judging by the presence of 11% mantle helium (3He) in fluid inclusions from quartz and the sulfur isotope composition (7.1-17.4‰ δ34S) of sulfides, ore-bearing fluids ascended from a mantle source along shear zones, where they “boiled”. While the fluids were ascending, the metalliferous S- and N-bearing hydrocarbon (HC) compounds they carried broke down to produce crystalline sulfides, gold, and disseminated graphite and amorphous carbon (the latter imparts the gray color to quartz). Barren veins of milky-white quartz formed from oxidized mainly aqueous fluids with a salinity of < 15 wt.% NaCl equiv at 150-350 °C. Chloride brines (> 30 wt.% NaCl equiv) at 150-260 °C impregnated the gold-bearing quartz veins and produced the lower strata of the hydrothermal-granitoid section. The gold mineralization (795-710 Ma) was roughly coeval to local high-temperature stress metamorphism (836-745 Ma) and intrusion of the Kalama multiphase complex (880-752 Ma). 相似文献
225.
3D打印(3D printing)是一种以三维模型为样本的快速成形技术,它通过逐层打印或粉末熔铸的方式来构造需要的立体图形。本文从3D打印技术的原理及其发展现状入手,重点列举内蒙古乌力吉敖包萤石矿,利用3D打印机打印具有现实可观性的地质体实体,探讨3D打印技术作为新兴的科技手段应用于矿床学教学与研究的应用价值和发展前景。研究发现,3D打印技术在矿体三维可视化中的应用符合地质图件立体化和3D打印技术多领域化的趋势,未来3D打印技术在地质领域的应用也有助于开拓矿床学教学和研究的新方式与新思路。 相似文献
226.
我国新型自主的极轨气象卫星风云3号A星(简称FY-3A)上搭载的中分辨率光谱成像仪(MERSI)为大面积雪监测提供了新的遥感数据源。以中国西北祁连山区为例,分析FY-3A/MERSI传感器积雪与其它地物的图谱特征差异,建立了适用于FY-3A/MERSI的归一化差分积雪指数(NDSI),以此为基础,构建了综合利用多光谱判别指标及土地覆盖类型(LULC)定类辅助的积雪判识模型,生成250 m分辨率的日积雪制图产品。模型通过逐步逼近的树状判别结构,去除了易和积雪混淆的部分乔木林、云、云阴影、水体、湖冰、沙(盐)地等地物,并提出应考虑积雪下覆地表特性的影响,调整设定不同LULC类型的积雪判别阈值约束,实时结合区域LULC影像进行积雪的最终判定与优化。对祁连山区2010-2011年积雪季FY-3A/MERSI影像的积雪制图应用结果表明,该资料能够客观精细地反映积雪的空间分布与动态发展过程。同时利用气象台站积雪观测记录及Terra/MODIS积雪判识结果进行对比验证,结果表明基于FY-3A/MERSI建立的积雪判识模型具有较高的精度和稳定性,特别是提高了云雪区分的效能。 相似文献
227.
塔里木溢流玄武岩火山通道的三维结构及其热成因气体释放 总被引:1,自引:1,他引:0
塔里木上奥陶统-志留系沉积地层中广泛发育早二叠世溢流玄武岩的火山通道相岩床-岩墙网络。三维地震数据解释结果显示,这些火山通道以平行围岩地层的岩床和斜切围岩地层的"碟状岩床"为主要特征。在玄武岩喷发过程中,火山通道岩浆的热量可以导致沉积围岩发生热接触变质并将沉积围岩中的有机质转化为"热成因气体"。在塔北英买2井区火山通道烘烤沉积围岩模型基础上,利用有限元热模拟方法确定了该区早二叠世玄武岩喷发时火山通道热烘烤影响范围随时间的变化。基于沉积围岩有机质丰度估算,该区热烘烤成因甲烷释放量可达11.3Gt(即113亿吨)。如果整个塔里木溢流玄武岩省具有与英买2地区相同的释放强度,则塔里木溢流玄武岩省活动期间释放的甲烷总量可达7062.5Gt,必然导致非常显著的环境效应。同时,玄武岩火山通道岩浆引起的热接触变质作用对已存在的油藏具有明显的破坏作用,塔里木盆地古生界总量约8~10Gt的油藏破坏和大量沥青的形成可能与此有关。 相似文献
228.
页岩气的有效开发依赖水平井的压裂效果,而页岩脆性是影响页岩压裂的关键因素。通过对比分析现有的3种脆性指数计算方法,即矿物脆性指数计算法、岩石力学脆性指数计算法、基于多元回归脆性指数计算法,优选基于多元回归的脆性指数计算法计算五峰—龙马溪组(简称龙马溪组)页岩储层脆性指数。以四川盆地东部南川地区龙马溪组海相页岩气为例,利用南川地区三维地震资料叠前反演方法,获取多元回归脆性指数计算方程所需的参数,预测页岩脆性指数。结果表明,在已有钻井矿物脆性指标约束下,叠前反演法计算的脆性指数平面预测效果较好,且与实际压裂数据具有较好的一致性,能够满足南川地区页岩气勘探开发的需要。 相似文献
229.
Wumeng Huang 《International Journal of Digital Earth》2018,11(9):939-955
3D city models, which are important items of content on the virtual globe, are characterized by complicated structures and large amounts of data. These factors make the visualization of 3D city models highly dependent upon the performance of computer hardware. Thus, achieving the efficient rendering of 3D city models using different hardware performance levels represents one of the key problems currently facing researchers. This paper proposes a time-critical adaptive visualization method that first estimates the possible rendering time for each model according to the data structure of the model in addition to the CPU/GPU performance of the computer. It then dynamically adjusts the rendering level for each model based on the results of an estimation of the rendering time to ensure that the final scene can be completed within a given time. To verify the effectiveness and flexibility of this method, it is applied using different computers. The results show that the adaptive visualization method presented in this paper not only can adapt to computers with different levels of performances but also demonstrates an obvious improvement in the time estimation precision, visual effects, and optimization speed relative to existing adaptive visualization methods. 相似文献
230.
Phenology is a sensitive and critical feature of vegetation and is a good indicator for climate change studies. The global inventory modelling and mapping studies (GIMMS) normalized difference vegetation index (NDVI) has been the most widely used data source for monitoring of the vegetation dynamics over large geographical areas in the past two decades. With the release of the third version of the NDVI (GIMMS NDVI3g) recently, it is important to compare the NDVI3g data with those of the previous version (NDVIg) to link existing studies with future applications of the NDVI3g in monitoring vegetation phenology. In this study, the three most popular satellite start of vegetation growing season (SOS) extraction methods were used, and the differences between SOSg and SOS3g arising from the methods were explored. The amplitude and the peak values of the NDVI3g are higher than those of the NDVIg curve, which indicated that the SOS derived from the NDVIg (SOSg) was significantly later than that derived from the NDVI3g (SOS3g) based on all the methods, for the whole northern hemisphere. In addition, SOSg and SOS3g both showed an advancing trend during 1982–2006, but that trend was more significant with SOSg than with SOS3g in the results from all three methods. In summary, the difference between SOSg and SOS3g (in the multi-year mean SOS, SOS change slope and the turning point in the time series) varied among the methods and was partly related to latitude. For the multi-year mean SOS, the difference increased with latitude intervals in the low latitudes (0–30°N) and decreased in the mid- and high-latitude intervals. The GIMMS NDVI3g data-sets seemed more sensitive than the GIMMS NDVIg in detecting information about the ground, and the SOS3g data were better correlated both with the in situ observations and the SOS derived from the Moderate Resolution Imaging Spectroradiometer NDVI. For the northern hemisphere, previous satellite measures (SOS derived from GIMMS NDVIg) may have overestimated the advancing trend of the SOS by an average of 0.032 d yr–1. 相似文献