基于数据挖掘分析中药复方治疗肺癌伴恶性胸腔积液的用药规律

目的：运用中医传承计算平台（V3.0）分析中医药治疗肺癌伴恶性胸腔积液的用药规律。方法：计算机检索2000年1月1日至2022年2月28日中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）中关于中药复方治疗肺癌伴恶性胸腔积液的文献,分析中药的性味归经、功效、频次、药物组合、关联规则及聚类等。结果：共纳入文献98篇,处方103首,中药197味。频次≥20次的中药有18味,排前10位的依次为葶苈子、茯苓、白术、黄芪、大枣、甘草、泽泻、桂枝、半夏、薏苡仁。四气以寒、温、平为主;五味以甘、苦、辛为主;归经以肺、脾、胃经为主。排前3位的功效依次为补虚、利水渗湿、化痰止咳平喘。用药频次≥20次的中药组合有37组,排前4位的依次为茯苓-葶苈子、白术-茯苓、茯苓-黄芪、大枣-葶苈子。支持度≥25%的核心药物为黄芪、白术、茯苓、甘草、葶苈子、大枣、桂枝、泽泻。中药聚类分析提取到4个核心组合。结论：肺癌伴恶性胸腔积液多属晚期,以气血阴阳俱虚为本,饮停胸胁为标,病机多虚实夹杂。中医药治疗此病多以甘温益气补虚治本,苦寒泻肺利水治标,同时兼以温阳化气。     

基于数据挖掘探讨中药治疗肝豆状核变性的用药规律

目的：基于数据挖掘探讨中药治疗肝豆状核变性的用药规律。方法：计算机检索1990年1月至2020年1月中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）中中药治疗肝豆状核变性的相关文献,利用Microsoft Excel 2010 进行频次分析,通过 SPSS Modeler 18.0、SPSS Statistics 23.0 对处方药物进行关联规则、复杂网络、系统聚类分析。结果：最终纳入文献161篇,筛选出处方151首,中药70味。中药频次排前5位的依次是泽泻、姜黄、大黄、黄连、丹参;功效排前5位的依次是利水渗湿、活血化瘀、清热、补虚、泻下药。二项关联多为利水渗湿、活血化瘀、清热、泻下药的组合,三项关联多为活血化瘀、清热、利水渗湿药的组合。聚类分析得到新方聚类的中药组合3类。结论：中医药治疗肝豆状核变性以清热化湿、活血化瘀为主,常用利水渗湿、活血化瘀、清热药,可配伍补虚及泻下药等。     

Study on the extremely cold winter of 1670 over the middle and lower reaches of the Yangtze River

The snow-cover days over the middle and lower reaches of the Yangtze River （MLRYR） in the winter of 1670 were extracted from Chinese historical documents. By these records, the winter temperature anomalies （compared to the mean of 1961-1990） recorded at seven meteorological stations and the regional mean winter temperature were estimated. The results show that： （1） There was an average of about 30 snow-cover days over the MLRYR region in 1670, ranging from 11-20 days in Shanghai and eastern Zhejiang to 5140 days in eastern Hunan Province. The snow-cover days averaged about 40 days in Anqing and Nan- cheng, and ranged from 30 to 40 days in Quzhou, Jingdezhen, and Nanchang; and （2） the regional mean winter temperature in 1670 was estimated to be approximately 4.0 ℃ lower than that of 1961-1990. The maximum negative anomaly of 5.6℃ occurred in Nanchang and the minimum anomaly of-2.8 ℃ was detected in Quzhou. Both of these were lower than that of the coldest winter during the instrumental observation period of 1951-2010. This research could not only provide a method to es- timate historical climate extremes, but also provide a background to understand the recent instrumentally climate extremes.     

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基于PSR 模型的厦门湾中华白海豚资源评价

中华白海豚(Sousa chinensis Osbeck,1765)为国家Ⅰ级重点野生保护动物,厦门湾作为其在中国的主要分布区之一,自20世纪80年代以来,海岸带开发活动和环境污染程度均不断加大,导致此海域中华白海豚的生存环境不断恶化,种群数量日趋减少,资源状况面临严重威胁。作者采用PSR(压力-状态-响应)模型框架,对厦门湾中华白海豚资源面临的主要环境压力、当前的资源状态以及采取的保护响应措施进行了一个较全面的评价,评价结果认为:围填海工程、船只交通、水下爆破作业和陆源排污等人类活动给厦门湾中华白海豚带来了生境缩小、身体伤害、环境污染和饵料短缺等严重影响,厦门市已采取的保护政策响应包括就地保护、迁地保护和公共管理等方面,目前种群资源数量稳定在80头左右并有潜力扩大。基于评价结果,作者提出了加强保护的建议和策略,可为厦门以外海区的中华白海豚保护工作提供参考。     

Chinese Contribution to CMIP5：An Overview of Five Chinese Models’Performances

An overview of Chinese contribution to Coupled Model Intercomparison Project-Phase 5 （CMIP5） is presented. The performances of five Chinese Climate/Earth System Models that participated in the CMIP5 pro ject are assessed in the context of climate mean states, seasonal cycle, intraseasonal oscillation, interan-nual variability, interdecadal variability, global monsoon, Asian-Australian monsoon, 20th-century historical climate simulation, climate change pro jection, and climate sensitivity. Both the strengths and weaknesses of the models are evaluated. The models generally show reasonable performances in simulating sea surface tem-perature （SST） mean state, seasonal cycle, spatial patterns of Madden-Julian oscillation （MJO） amplitude and tropical cyclone Genesis Potential Index （GPI）, global monsoon precipitation pattern, El Ni-no-Southern Oscillation （ENSO）, and Pacific Decadal Oscillation （PDO） related SST anomalies. However, the perfor-mances of the models in simulating the time periods, amplitude, and phase locking of ENSO, PDO time periods, GPI magnitude, MJO propagation, magnitude of SST seasonal cycle, northwestern Pacific mon-soon and North American monsoon domains, as well as the skill of large-scale Asian monsoon precipitation need to be improved. The model performances in simulating the time evolution and spatial pattern of the 20th-century global warming and the future change under representative concentration pathways pro jection are compared to the multimodel ensemble of CMIP5 models. The model discrepancies in terms of climate sensitivity are also discussed.     

古代山水画之于玉雕山子借鉴意义探幽

抽象的文字概念和直观的视觉呈现,都佐证着玉雕山子与中国山水画之间存在某种必然的关系,这种关系并不复杂,但很微妙.玉雕山子与中国山水画的区别不仅只是图像载体不同所带来的差异,二者所涵盖的内容范围有着根本的区别.本文试图从中国山水画的角度出发,探讨二者在表现范围上的本质区别,阐明中国山水画对玉雕山子在表现内容、透视方法、空间布局、技法风格、审美追求、理论构建、艺术品评等多个方面的发展所起到的借鉴意义.对于当代玉雕山子和当代中国山水画二者之间出现疏离现象的原因,本文也进行了简单的分析.     

Effects of Crustal Structure for Estimation of Vertical Load Deformation on the Solid Earth Using GRACE in China Mainland

When the inversion of vertical load deformation on Earth’s surface using GRACE (Gravity Recovery and Climate Experiment) data, the load Love numbers based on PREM (Preliminary Reference Earth Model) are commonly used. But the crustal structure under China mainland especially under Tibet Plateau is quite different from that given by PREM Earth model. New load Love numbers were calculated based on a modified Earth model which accounted for regional crustal structure in China mainland. And the effect of regional crustal structure in China mainland for estimation of vertical load deformation on Earth’s surface using GRACE RL05 data was investigated in this paper. It is found that the effect of crustal difference is very prominent. The relative difference of load Love numbers for vertical deformation can reach about 11% at degree 90. The extreme value of difference in vertical load deformation below 90 degree of spherical harmonic coefficients located at the southeastern Tibet Plateau and the maximum relative difference reaches 10%. The relative difference of the root mean square is about 4%. It is suggesting that an Earth model with a more realistic crustal structue instead of PREM should be used for the estimation of vertical load deformation in China mainland espacially in Tibet Plateau.     

西南地区传统村落区域保护水平评价及影响因素

本文在理论层面构建传统村落保护研究模型,并以西南地区为例,分析宏观视角下传统村落区域保护水平及影响因素。结论显示：① 传统村落保护研究模型涵盖评价体系和影响因素两个子模型。评价体系模型包含从宏观到微观的传统村落时空分布、整体保护水平和单一属性3个层次,其中整体保护水平分为宏观区域和微观社区两个亚层,保存率和分布密度是评价区域保护水平的简易方法;影响因素模型包含基于时间、空间和类型划分的两类基本分析模型。② 西南地区传统村落区域保护水平呈现显著空间分异,在行政区划边界地区形成5个热点集聚区,丽江市传统村落保存率最高,黔东南州分布密度最高。③ 影响西南地区传统村落宏观保护水平的地理区位因素为海拔、水系、中心城市和交通干道。经济社会因素中,非遗规模是最重要的影响因素,人口密度、经济发展、交通建设、交通流动和非遗规模的相关系数存在显著空间分异,城镇化率、产业结构对于区域保护水平无显著影响。本文是对传统村落保护理论体系由个案向整体、由微观向宏观、由零散向系统、由单一向多元方法的推进,具有重要理论和实践价值。     

儿童地理学视角下的留守儿童研究述评

文章通过梳理在WOS（Web Of Science）核心数据集、谷歌学术、中国知网（CNKI）等平台筛选出的较高引用率、方法比较规范、与留守儿童主题相关性强的国内外文献159篇,从理论层面总结了儿童地理学研究的新转向：关注儿童与空间的关系,强调儿童在空间使用中的主体性,重视不同情境下儿童地理体验的差异性。并梳理了跨国迁移背景下留守儿童的3个研究主题：从空间视角探讨留守儿童的日常生活实践;从主体性出发探讨儿童在迁移链中的体验;在童年的差异性基础上讨论本土儿童的问题。同时从问题视角和积极视角分析了国内城乡迁移背景下留守儿童的研究主题,指出因现有研究范式中的经验主义和成人中心主义而存在的局限性。尝试勾勒出符合中国情境的留守儿童研究新范式,提出留守儿童的日常生活空间,留守儿童的能动性、异质性和多样性是国内留守儿童研究亟需关注的内容。呼吁学者采用历时和动态的研究设计,充分展现儿童如何理解、体验和应对复杂的流动背景下的日常生活。