基于网络药理学和分子对接探讨左金丸治疗肝癌的作用机制

目的：运用网络药理学和分子对接方法探讨左金丸治疗肝癌的作用机制。方法：从TCMSP和BATMAN-TCM数据库获取左金丸的化合物及其相应靶点,检索GeneCards、OMIM和TTD 3个数据库获得肝癌的相关靶基因,取两者靶基因交集得到左金丸治疗肝癌的预测靶基因;运用Cytoscape 3.7.1软件构建左金丸-化合物-靶点-肝癌和PPI网络图;运用R软件对预测靶基因进行GO和KEGG富集分析;最后运用分子对接技术对关键化合物和靶点进行验证。结果：共获取左金丸35个化合物及173个相应靶点,左金丸与肝癌的共同靶点有103个。PPI结果表明AKT1、MAPK1、TP53、JUN和RELA可能为左金丸治疗肝癌的关键靶点。富集分析示左金丸可能通过乙型肝炎、卡波西肉瘤相关疱疹病毒感染、人巨细胞病毒感染、丙型肝炎、MAPK信号通路、肝癌等信号通路抗肝癌。分子对接结果示槲皮素和黄连素均能与AKT1和MAPK1稳定结合。结论：本研究初步揭示了左金丸通过多成分、多靶点、多通路治疗肝癌的作用机制,为后续左金丸治疗肝癌提供理论参考。     

Developing and Sequencing Community Engagement and Experiential Education: A Case Study of Urban Geography Teaching and Research

Community engagement curricula and course design can provide substantial experiences for both community members and participating students. Using a case study approach, this research focuses on four steps in this process: initial community relationship forming, engaging in community service, transitioning to civic engagement, and developing a community-based research program. Narrative examples from student course evaluations position these community-based experiences as transformative for multiple parties. Institutional structures are presented as helpful entrees to engagement for students, while noting that community relationships provide contextualized, powerful, and meaningful relationships, supporting recommendations for emerging and existing community engagement programs.     

传承和发扬人文与经济地理学前辈的精神和知识体系——人文与经济地理学青年论坛综述

2018年1月27-28日,人文与经济地理学青年论坛暨第二届中国科学院区域可持续发展分析与模拟重点实验室青年论坛在北京国家会议中心成功举办。论坛以“人文与经济地理学的传承与创新：青年学者的责任与行动”为主题,来自全国100余家高校和研究机构从事人文与经济地理学相关研究的青年学者370余人参会。这说明人文与经济地理学青年学者很活跃、有热情、有担当意识。青年学者要加强学习、传承和发扬人文与经济地理学前辈的精神和知识体系,迎接人文与经济地理学繁荣发展的新时代。     

Responses of Riverbed Particles to Geomorphologic Processes in Aeolian-Fluvial Action Area: A Case Study of the Heilaigou Basin in Inner Mongolia of China

The Heilaigou basin, located in the Inner Mongolia of China, is predominantly influenced by the aeolian-fluvial actions, with complicated sediment transport conditions on the mainstream riverbed. In order to identify the relationship between sedimentary particles and geomorphic processes, mechanisms for the formation of characteristics of grain size composition were investigated by analyzing grain size parameters and external dynamic geomorphologic features. Firstly, the grain size parameters of the riverbed, stream power, maximum grain size of the wind-blown particles and HI values of the mainstream channel were calculated and analyzed, and they were used to establish multiple regression functions of grain size parameters in order to determine the effects of wind and river actions on particles. The results show that sediments in different reaches are formed in different environments: the upper stream is controlled by fluvial and aeolian processes; the sorting properties of riverbed sediments in the middle stream are worse than those in the upper stream since they are affected mainly by fluvial processes as indicated by the larger stream power there; and the particles on the downstream riverbed are likely contributed by the Kubuqi Desert. The size of particles on the riverbed depends on the hydrodynamic conditions, but is not significantly associated with the evolution of landform. Sorting is significantly related to both the hydrodynamic conditions and wind actions. Riverbed deposits brought in by winds likely become finer from the lower to the upper reaches, which are not coarser than 0.88f. Generally speaking, the stream power has a major effect on sedimentation characteristics of the riverbed, followed by wind power.     

“一带一路”战略的河南行动

"一带一路"战略是我国现代化建设与世界和平发展的一项世纪伟业。河南参与建设"一带一路"的行动,要以发挥优势、主动融入、服务大局为宗旨,把实施三大国家战略纳入"一带一路"框架内。构建全方位对外开放的新格局、大格局,努力推动基础设施联通、能源资源拓展、金融保障构筑、经贸产业深化、人文交流强化等领域的筹划与协作。完善一个载体,打造四个体系,组建大郑州都市地区,形成我国内陆腹地支撑"一带一路"的"中原板块"。     

干旱环境胁迫下农户适应性研究——基于民勤绿洲地区农户调查数据

适应能力及其评估框架为农户生计研究提供了一个新思路。本文在干旱环境背景下,借鉴农户可持续生计和适应能力相关理论,探讨民勤绿洲地区农户适应能力及适应行为。按照适应能力评估框架,构建农户适应能力评价指标体系,通过问卷和实地调查获取数据,在农户适应行为分类的基础上,测量不同适应类型农户的适应能力,分析影响农户适应类型的因素。结果表明：①从农户的适应行为来看,积极主动的适应行为选择较多,减少消费、参加社会保险等适应行为选择较少;农户适应类型中,综合适应型的比重最大,被动适应型最小。②农户的适应能力方面,各维度整体分布较为均衡,但自然能力和社会能力存在显著分异,而物质能力、金融能力、劳动能力和学习能力较均衡;不同农户适应类型中,综合适应型农户适应能力更稳定,务工主导型和被动适应型的稳定性较差。在适应能力六大维度中,物质能力在六大农户适应类型中所占比重最大,自然能力最小。③家庭物质资产、非农就业比重、社会网络、人均“退还关压”面积、受教育程度等适应能力指标对农户的适应行为选择具有显著影响。     

泡沫钻进中的腐蚀现象与泡沫发生器

泡沫钻进中有两个问题有待解决。第一是泡沫对钢铁具有明显的腐蚀作用。由于泡沫中有水和大量空气,而空气中含有氧。钢铁的腐蚀主要是水与氧的作用。在氧化锈蚀过程中发泡剂也起着重要作用。为此提出了防腐措施。第二是泡沫的发生。稳定泡沫的产生必须具备两个条件:物质条件和机械条件。没有发泡剂的加入不会产生稳定的泡沫。没有强有力的机械作用,气体进入不了液膜,也不会发泡。相应的措施是设专门的泡沫发生器。      

大型泊位设计中的水流问题——以宝钢马迹山港为例

本文以宝钢马迹山２５万吨级矿石中转港码头设计中所遇到的水流问题为例,通过对研究水域的水流性质以及泊位、船舶、水流三者之间关系的初步分析,认为水流尽管与风、浪一样不致船舶结构破坏,但一定时段内却可能对其靠泊造成困难,而水流作用于系泊中船舶并传递给码头结构物的荷载,以及水流与波浪相互作用使得波流要素改变则是设计中必需考虑的。最后,作者对港口设计和运作提出建议,以期相类似水深流急地区建设大型泊位时能有所借鉴。     

溃屈型滑坡稳定性分析中三个问题的探讨

针对溃屈型滑坡稳定性分析中的三个问题,即滑带土强度参数的分段取值,顺层段与切层段分界点和水的作用,逐一进行初步探讨。     

台风风暴潮气压项作用探讨

在台风风暴增水过程中,风应力占主要作用,气压项的作用要上对较小,许多风暴潮预报模式中气压项被忽略。本文在建立台湾海峡风暴潮预报模型的基础上峄台风气压项作用进行了模拟,结果发现在台湾海峡狭长的海域内,台风气压项的作用表现得较为特殊,在台风风暴潮模拟过程中,应考虑其贡献及大小。