Analysis of fault scaling relations using fault seismic attributes

We have studied three‐dimensional fault geometries through a geologically integrated analysis of fault seismic attribute volumes. We used a series of coherence (semblance) and filtered coherence attribute volumes with parameters optimised for imaging faults in the studied seismic volumes. Fault geometric attributes such as along strike segment length and displacement were measured on fault seismic attributes. The scaling relationships of fault geometric attributes were studied using statistical methods such as the Bayesian information criterion, the likelihood ratio test, and the bootstrap method. Univariate distributions of fault segment length and maximum displacement show a truncated power law for most of the fault data. The statistical results indicate a piecewise‐linear relation with two slopes between depth and fault segments lengths: depth and mean displacement. For these relations, we observe consistent increases in fault segment lengths and mean displacements from the lower tip of the fault at depth toward a point of inflection at shallower depth at the vertical section. From that point, a reduction in fault segment lengths and mean displacements toward the upper tip of the fault at the shallower depth occurs. Fault segmentation along strike increases toward the lower and upper tips of the fault, but the maximum number of segments are located near the lower tip of the fault in two of the studied faults. The fault segment length is maximum, where the number of segments (along strike) is least close to the middle of the fault in the vertical section.     

金枪鱼(Thunnus sp.)胰腺酶解液对H2O2诱导的胰岛素瘤细胞(INS-1)氧化损伤的保护作用

本文首先通过MALDI-TOF/TOF-MS技术,测定金枪鱼(Thunnus sp.)胰腺酶解液中的多肽组分及其丰度,确定GQPVR、GLPPK和EHER是其中的优势肽;再利用Discovery Studio平台中的反向找靶和分子对接模块,发现这些优势肽均可以与Keap1蛋白结合,推测其可能具有抗氧化活性;最后,利用细胞实验对酶解液的抗氧化活性进行验证,发现其对H2O2氧化损伤的胰岛素瘤细胞(INS-1)具有剂量依赖型保护效果,高剂量和低剂量酶解液处理后细胞活力较模型组显著提高,凋亡率从79.17%分别下降到43.2%(P0.01)和28.9%(P0.01);胰岛素的分泌量从3.65mIU/L分别增加到5.75mIU/L(P0.01)和4.95mIU/L(P0.01)。DiscoveryStudio的抗氧化功能预测和细胞学实验相结合的研究方法,为酶解液的功能组分鉴定提供了新的思路。     

AUV水下对接装置控制系统设计

自主式水下机器人(Autonomous Underwater Vehicle,简称AUV)在航行使命结束后需要回收至甲板或陆地进行补给和维护。为避免重复布放回收所带来的不便,根据锥形导向式回收原理,针对水下对接装置及其控制系统进行了设计。水下对接装置控制系统由水面控制终端,水下控制系统和水下外部设备等部分组成,使用超短基线引导AUV进入指定区域,在对接过程中依靠行程开关和无线电反馈的信息判断AUV的相对位置及状态,并通过驱动相应的液压机构对AUV姿态进行校正和固定,进而完成对接过程。水下对接装置在千岛湖进行了试验,在吊装水下7 m的情况下实现了AUV的水下对接,并利用湿插拔电连接器完成了对AUV的有线充电和数据上传。试验验证了对接方案的可行性以及控制系统的稳定性,为将来AUV能够进行长时间、不间断航行提供了可能。     

盐井定向对接施工工艺研究

通过丰县采1、采2-对盐井施工实例,介绍了盐井定向对接工程的特点以及主要施工仪器、设备性能;运用微积分学对钻井定向段进行了精确设计,对地质模型进行了数字化处理,为工程提供了可靠的施工依据,同时也为该类工程施工提供了技术参考意见。     

基于网络药理学及分子对接探讨重连口服液治疗流行性感冒的作用机制

目的：利用网络药理学及分子对接探讨重连口服液治疗流行性感冒的作用机制。方法：通过TCMSP、PubChem、Swiss Target Prediction平台以及相关文献获取重连口服液所含中药的活性成分及对应靶点;通过DisGeNET、DrugBank、Herb数据平台获得流感相关靶点;将有效成分的靶点映射到流感靶点,得到交集靶点即为重连口服液抗流感的潜在靶点;利用Cytoscape软件和String数据库建立化合物-靶点网络及靶蛋白互作（PPI）网络;通过R语言clusterProfiler工具包对核心靶点进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析。结果：根据筛选条件获取160个活性成分,59个潜在靶点;经网络拓扑分析筛选出重连口服液前5位重要成分为：槲皮素、木犀草素、山柰酚、汉黄芩素、β-谷甾醇,2个重要靶蛋白转录因子P65（RELA）、丝裂原活化蛋白激酶14（MAPK14）。通过分子对接显示5个重要成分与RELA、MAPK14结合能均＜-5.0 kcal/mol。GO富集分析发现重连口服液作用的生物途径与调节脂多糖、细菌源分子等有关系;KEGG通路富集分析表明重连口服液治疗流感涉及IL-17信号通路、TNF信号通路等。结论：重连口服液以多种成分通过调控RELA、MAPK14等靶蛋白,作用于多种生物途径以抑制病毒的复制,减轻炎症反应,调节机体免疫,调控氧化应激等,从而起到抗流感的治疗作用。     

基于网络药理学和分子对接探讨十味温胆汤治疗心绞痛的作用机制

目的：采用网络药理学及分子模拟对接的研究方法探讨十味温胆汤治疗心绞痛的潜在作用机制。方法：通过TCMSP、TCMID数据库获取十味温胆汤组方（半夏、陈皮、茯苓、黄芪、人参、熟地黄、酸枣仁、五味子、远志、枳实）的有效成分及对应的靶蛋白;使用GeneCard、OMIM数据库筛选出与心绞痛密切相关的作用靶点。运用CytoScape软件构建中药-组分-靶点网络图,运用STRING数据库构建蛋白质-蛋白质相互作用（PPI）网络图。利用R软件对中药-疾病交集靶点进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析。结果:十味温胆汤治疗心绞痛的核心药物成分是柚皮素、山柰酚、β-谷甾醇、槲皮素、川陈皮素等;核心靶点有肿瘤坏死因子(TNF)、丝氨酸/苏氨酸蛋白激酶(AKT1)、白细胞介素-6(IL-6)、血管内皮生长因子A(VEGFA)、白细胞介素-1β(IL-1β)等;十味温胆汤主要通过晚期糖基化终产物受体（AGE-RAGE）、脂质代谢、流体剪切应力、前列腺癌、乙型肝炎等信号通路来治疗心绞痛;分子模拟对接结果显示,十味温胆汤中槲皮素、山柰酚与Akt1、TNF均能实现较好的结合。结论：十味温胆汤可能通过调控细胞增殖与凋亡、血管生成、炎症反应、抗氧化应激等作用协同治疗心绞痛。     

A new seismic attribute for ambiguity reduction in hydrocarbon prediction

Hydrocarbon prediction from seismic amplitude and amplitude‐versus‐offset is a daunting task. Amplitude interpretation is ambiguous due to the effects of lithology and pore fluid. In this paper, we propose a new attribute “J” based on a Gassmann–Biot fluid substitution to reduce ambiguity. Constrained by seismic and rock physics, the J attribute has good ability to detect hydrocarbons from seismic data. There are currently many attributes for hydrocarbon prediction. Among the existing attributes, far‐minus‐near times far and fluid factor are commonly used. In this paper, the effectiveness of these two existing attributes was compared with the new attribute. Numerical modelling was used to test the new attribute “J” and to compare “J” with the two existing attributes. The results showed that the J attribute can predict the existence of hydrocarbon in different porosity scenarios with less ambiguity than the other two attributes. Tests conducted with real seismic data demonstrated the effectiveness of the J attribute. The J attribute has performed well in scenarios in which the other two attributes gave inaccurate predictions. The proposed attribute “J” is fast and simple, and it could be used as a first step in hydrocarbon analysis for exploration.     

航天器交会对接远程导引段的精密轨道确定

探讨了CEI技术在飞船交会对接远程导引段的高精度定位与监控的能力,采用了差分相位延迟和相位延迟率为观测量进行轨道解算,仿真结果表明可满足远程导引段的精度指标。     

盐井定向对接施工工艺研究

通过丰县采1、采2-对盐井施工实例,介绍了盐井定向对接工程的特点以及主要施工仪器、设备性能;运用微积分学对钻井定向段进行了精确设计,对地质模型进行了数字化处理,为工程提供了可靠的施工依据,同时也为该类工程施工提供了技术参考意见。     

第二次全国土地调查数据库建设方法研究

第二次全国土地调查全面查清了全国土地利用状况,掌握真实的土地基础数据,将这些数据最终以数据库的方式进行储存和管理。介绍了建库要求,阐述了数据入库前的检查步骤,研究了数据库建设的方法和步骤,给出了数据库建设流程。