女性乳腺癌MRI扩散特征与HER-2表达相关性初步研究

目的:探讨女性乳腺癌MR扩散加权成像(DWI)表观扩散系数(ADC)与HER-2表达的相关性。方法:回顾性分析2018年至2019年于本院就诊并经手术证实的31例女性乳腺癌患者MR功能成像中病灶组织的扩散特征及ADC的范围,并使用免疫组织化学方法观察HER-2受体表达的情况。结果:乳腺癌组织在DWI图像b=0序列上呈等信号,而在b=800序列上呈高信号;所有病例病灶组织ADC的范围约为(0.78±0.18)×10^-3/mm²;HER-2阳性表达的患者ADC范围约为(0.88±0.27)×10^-3/mm²;HER-2阴性表达的患者ADC范围约为(0.77±0.19)×10^-3/mm²。结论:HER-2阳性表达的患者ADC值较阴性表达者的ADC高,在ADC为(0.88±0.27)×10^-3/mm²范围内HER-2阳性表达率较高,由此可见MR功能成像中ADC对女性乳腺癌患者的临床病理分型及术后治疗方案的选择有重要的参考...     

Multi-Model Projection of July–August Climate Extreme Changes over China under CO_2 Doubling. Part II: Temperature

This is the second part of the authors’ analysis on the output of 24 coupled climate models from the Twentieth-Century Climate in Coupled Models (20C3M) experiment and 1% per year CO 2 increase experiment (to doubling) (1pctto2x) of phase 3 of the Coupled Model Inter-comparison Project (CMIP3). The study focuses on the potential changes of July–August temperature extremes over China. The pattern correlation coefficients of the simulated temperature with the observations are 0.6–0.9, which are higher than the results for precipitation. However, most models have cold bias compared to observation, with a larger cold bias over western China (>5°C) than over eastern China (<2°C). The multi-model ensemble (MME) exhibits a significant increase of temperature under the 1pctto2x scenario. The amplitude of the MME warming shows a northwest–southeast decreasing gradient. The warming spread among the models (～1°C– 2°C) is less than MME warming (～2°C–4°C), indicating a relatively robust temperature change under CO 2 doubling. Further analysis of Geophysical Fluid Dynamics Laboratory coupled climate model version 2.1 (GFDL-CM2.1) simulations suggests that the warming pattern may be related to heat transport by summer monsoons. The contrast of cloud effects also has contributions. The different vertical structures of warming over northwestern China and southeastern China may be attributed to the different natures of vertical circulations. The deep, moist convection over southeastern China is an effective mechanism for "transporting" the warming upward, leading to more upper-level warming. In northwestern China, the warming is more surface-orientated, possibly due to the shallow, dry convection.     

Diurnal Variations of Hydrochemistry in a Travertine-depositing Stream at Baishuitai, Yunnan, SW China

Diurnal variations of hydrochemistry were monitored at a spring and two pools in a travertine-depositing stream at Baishuitai, Yunnan, SW China. Water temperature, pH and specific conductivity were measured in intervals of 5 and 30 min for periods of 1 to 2 days. From these data the concentrations of Ca²⁺, HCO₃⁻, calcite saturation index, and CO₂ partial pressure were derived. The measurements in the spring of the stream did not show any diurnal variations in the chemical composition of the water. Diurnal variations, however, were observed in the water of the two travertine pools downstream. In one of them, a rise in temperature (thus more CO₂ degassing) during day time and consumption of CO₂ due to photosynthesis of submerged aquatic plants accelerated deposition of calcite, whereas in the other pool, where aquatic plants flourished and grew out of the water (so photosynthesis was taking place in the atmosphere), the authors suggest that temperature-dependent root respiration underwater took place, which dominated until noon. Consequently, due to the release of CO₂ by the root respiration into water, which dominated CO₂ production by degassing induced by temperature increase, the increased dissolution of calcite was observed. This is the first time anywhere at least in China that the effect of root respiration on diurnal hydrochemical variations has been observed. The finding has implications for sampling strategy within travertine-depositing streams and other similar environments with stagnant water bodies such as estuaries, lakes, reservoirs, pools and wetlands, where aquatic plants may flourish and grow out of water.     

Genetic algorithm for fitting a mixed Bingham distribution to 3D orientations: a tool for the statistical and paleostress analyses of fracture orientations

The clustering of fracture orientations is important for tectonic studies and for geotechnical engineering. In this study, a real‐coded genetic algorithm was adopted to fitting a mixed Bingham distribution to orientation data by maximizing the log‐likelihood function of the distribution. The maximization is a difficult problem, because the function has multimodality and singularity. It was found that the algorithm was effective for this problem. Given the orientations of dilational fractures, the present method determines not only the stress axes and stress ratio of each of the fracture groups but also the maximum non‐dimensionalized fluid pressure at the time of their formation. In addition, the software calculates the 95 % error ellipses of the concentration axes. The present method found that the orientations of ore veins of the Akenobe Mine, SW Japan, should be partitioned into three clusters. It is shown that two of the groups had distinctive Zn and Sn contents, and that the ore fluids had overpressures only slightly greater than the minimum principal stress at the time of the deposition of Zn‐ and Sn‐rich veins.     

Theory of Basin Scale Dynamics of a Stratified Rotating Fluid

The dynamics of a stratified fluid contained in a rotating rectangular box is described in terms of the evolution of the lowest moments of its density and momentum fields. The first moment of the density field also gives the position of the fluids centre-of-mass. The resulting low-order model allows for fast assessment both of adopted parameterisations, as well as of particular values of parameters. In the ideal fluid limit (neglect of viscous and diffusive effects), in the absence of wind, the equations have a Hamiltonian structure that is integrable (non-integrable) in the absence (presence) of differential heating. In a non-rotating convective regime, dynamically rich behaviour and strong dependence on the single (lumped) parameter are established. For small values of this parameter, in a self-similar regime, further reduction to an explicit map is discussed in an Appendix. Introducing rotation in a nearly geostrophic regime leads through a Hopf bifurcation to a limit cycle, and under the influence of wind and salt to multiple equilibria and chaos, respectively.     

Synthesis and Characterization of Poly(2‐hydroxyethylmethacrylate‐hydroxyapatite) a Novel Composite for the Removal of Lead(II) from Aqueous Solutions

In the present study, a novel adsorbent, poly (2‐hydroxyethylmethacrylate‐hydroxyapatite) [P(HEMA‐Hap)], was prepared and characterized. The synthesis was achieved by means of free‐radical polymerization and a number of structural characterization methods, including FT‐IR, XRD, TGA, SEM, BET‐porosity, and swelling tests. Pb²⁺ adsorption was performed using a series of pH, time, and temperature ranges. The reusability of the composite was also tested. The results obtained indicated that the novel adsorbent is able to bind Pb²⁺ ions with strong chemical affinity. The adsorption results were fitted to the classic Langmuir, Freundlich, and Dubinin–Radushkevich (D–R) sorption models. Thermodynamic parameters obtained demonstrated that the sorption process was spontaneous (ΔG < 0), endothermic (ΔH > 0), as expected. The process was also consistent with the pseudo‐second‐order model, and chemical adsorption was determined to be the rate‐controlling step. It was also shown that the composite could be used for five consecutive adsorption processes.     

Toxic effects of Zn2+, Cu2+, Cd2+ and NH3 on Chinese prawn

This study deals with the toxic effects of Zn²⁺, Cu²⁺, Cd²⁺ and NH₃ on Chinese prawn (Penaeus orientalis). The median lethal concentrations of the toxic matters on Chinese prawn were determined. Cd²⁺>Cu²⁺>Zn²⁺>NH₃-Nm is the toxic order of these chemicals to Chinese prawn. The toxic order of concentrated Zn²⁺ and Cd²⁺ in tissues and organs of Chinese prawn is in the order. gill>shell+appendage>viscera>muscle.     

A signature of the donor star in the extra-galactic X-ray binary LMC X−2

Two nights of phase-resolved medium-resolution Very Large Telescope spectroscopy of the extra-galactic low-mass X-ray binary LMC X−2 have revealed a 0.32 ± 0.02 d spectroscopic period in the radial velocity curve of the He  ii λ4686 emission line that we interpret as the orbital period. However, similar to previous findings, this radial velocity curve shows a longer term variation that is most likely due to the presence of a precessing accretion disc in LMC X−2. This is strengthened by He  ii λ4686 Doppler maps that show a bright spot that is moving from night to night. Furthermore, we detect narrow emission lines in the Bowen region of LMC X−2, with a velocity of   K _em= 351 ± 28 km s⁻¹  , that we tentatively interpret as coming from the irradiated side of the donor star. Since K _em must be smaller than K ₂, this leads to the first upper limit on the mass function of LMC X−2 of   f ( M ₁) ≥ 0.86  M_⊙  (95 per cent confidence), and the first constraints on its system parameters.     

The Orbital Evolution of Two Sounding Satellites and Analysis of the Accuracy of Orbit Determination

The satellites TC-1 and TC-2 are the two Chinese satellites with great elliptical orbits which are still in orbit around the earth at present. Since the launch the orbits of the two satellites have continuously evolved, which has a certain effect on the orbit determination and prediction precision. The regularities of the orbital evolution of the two sounding satellites are qualitatively and quantitatively analyzed. Under the current tracking mode the corresponding prediction precision of orbit determination is analyzed based on the different stages of the orbital evolution, thereby providing the basis for the adjustment of planning mode by the satellite application departments and the guarantee of normal satellite payload. Finally, the orbital lifetimes of the two satellites are predicted through the trend of the orbital evolution.