基于GEO数据库和网络药理学探讨猫爪草治疗原发性肝癌的作用机制

目的：利用GEO数据库和网络药理学分析猫爪草治疗原发性肝癌（HCC）的作用机制。方法：借助HERB数据库、SwissADME及SwissTargetPrediction筛选猫爪草的有效成分与作用靶点。从GEO数据库中筛选正常肝脏组织患者与肝癌患者的差异表达基因,整合GeneCards、DisGeNET、GEO数据库得到HCC疾病靶点、疾病和成分的交集基因,利用Cytoscape 3.9.0构建成分-疾病网络及拓扑分析,在David数据库进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。结果：获得猫爪草活性成分36种,潜在靶点544个,差异表达基因1 950个。核心靶点包括血管内皮生长因子A、信号转导与转录激活因子3、胱天蛋白酶3、非受体酪氨酸激酶、缺氧诱导因子-1α、表皮生长因子受体等。GO功能富集分析发现生物过程涉及对异物刺激的反应、丝裂原活化蛋白激酶级联的积极调节、跨膜受体蛋白酪氨酸激酶信号通路等方面;细胞组成主要集中在细胞质、细胞核和细胞外泌体等;分子功能主要集中在蛋白质结合、酶活性、脱氧核糖核酸结合等。KEGG通路主要涉及癌症、磷脂酰肌醇-3-激酶/蛋白激酶B、催乳素、缺氧诱导因子-1、乙型肝炎等。结论：猫爪草治疗肝癌具有多成分、多靶点、多途径等特点,为今后的进一步研究提供了理论依据。     

北海北部盆地储层特征及其成岩作用分析

北海北部油气区的储层发育范围很广,自断裂基底至始新世均有发育。主要储层有5套:①二叠系风成或河成砂岩;②三叠系河流相砂岩;③中、下侏罗统河成、三角洲以及边缘海砂岩;④上侏罗统浅海和深海浊流砂岩及砾岩;⑤上白垩统—下古新统白垩和古新统深海浊积扇砂岩。古新世—始新世砂岩成岩作用有限,在3 100 m之下,渗透性逐渐变差,先是由于钾长石的溶解作用,约3 700 m之下伊利石是主要影响因素,约4 000 m之下则是次生石英的影响。主要储集层的分布是北北海油气远景区的重要控制因素。     

西安地区高层建筑桩土共同作用非线性研究

对西安地区桩土共同作用的研究现状进行分析,并对目前共同作用的计算理论研究进行总结．探讨了共同作用地基非线性,对西安地区高层建筑桩土共同作用数值模拟及动力反应研究成果和有待于进一步研究的问题作了介绍。     

用文字推动环境革命

夕什马里夫(Shishmaref)是位于阿拉斯加萨里切夫(Sarichef)岛上的一个因纽特人村庄。20世纪90年代,该村庄居民发现了海冰凝固晚而融化早的现象,这种变化意味着他们传统的海豹狩猎方式不再安全,那些本应在毁灭性的暴风巨浪里起着防护作用的冰层外缘,再也无法为这个小城镇充当缓冲区了。全球变暖正在把夕什马里夫拖入毁灭的境地。为了生存,村民们最近决定要迁移到大陆居住。很快,萨里切夫岛上的夕什马里夫就将从地图上消失。     

IGC 2004——Urbino International Workshop to discuss some new concepts in global tectonics

In the context of the 32^nd International Geological Congress, the University of Urbino which is about to celebrate its 500^th anniversary hosted the post-Congress Workshop PWO-09 from 29^th to 31^st August 2004 dedicated to “New Concepts in Global Tectonics：Emphasis on Some Fundamental Questions in Geology”, convened and organized by Forese Carlo Wezel.     

浅析沁水地块的地壳波浪运动及成煤作用

本文运用张伯声教授的学说,从含煤地层的岩石组合及其展布特征,沉积旋回及波浪运动与成煤作用的内在联系,阐述了沁水盆地富煤带的形成、展布及煤质和其它伴生矿产的关系。     

牛头山地区玄武岩类的高压分异作用

The Nutoushan basaltic cone, eonsisting of subalkali (quartz-tholeiite and olivinetholeiite) and alkali basalts, is Late Tertiary in age. Its major characteristics are generalized as follows: (1) Both early subalkali and late alkali basalts are formed under the same geological environment. (2) The continuity in chemical composition from snbalkali to alkali and the low FeO/MgO in alkali basalts show that they arc the products of cognate magmatic diffcrcntiation. (3) The change from low REE abundance and weak enrichment of LREE in subalkali to high REE abundance and strong enrichment of LREE in alkali basalts indicates obvious REE cnrichment and fractionation during magmatic differentiation.Weak positive Eu anomalies in the REE patterns arc indicative of their formation under low oxygen fugacity conditions. (4) According to the calculated values, 70-75% of the primary olivine tholeiitic magma had been separated as subalkaline basalic magma, the rest residual magma became alkaline basaltic magma. This result is consistent to the field observation that the outcrop area of subalkali basalts is four times as much as that of alkali basalts. (5) The basaltic rocks of Nutoushan show an S-type distribution straddling the thermal barrier on Ol‘-Ne‘-Qu‘ diagram and an evolution tendency for Ne to increase with increasing FeO/MgO. This is in agreement with the melting experimental data on olivine basalts at 10-20 kb. (6) Mantle-derived inclusions (spinel lherzolite) in this area occur in both alkali olivine basalts and olivine tholeiites. The latter is of extremely rare oceurrence. The formation temperature and pressure of the inclusions in alkali basalts and olivine tholeiites have been calculated. The results silow that the alkaline basaltic magma was separated from the subalkaline basaltic magma at about 20 kb. Basaltic rocks in Nutoushan were formed through the soealled “high pressure differentiation”, that is, at about 20 kb the crystallization of clinopyroxene and orthpyroxene resulted in the separation of subalkaline basaltic magma from the primary olivine tholeiitic magma, and then the residue gradually became alkaline olivine basaltic magma.