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41.
目的:基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法:应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体(GO)功能、京都基因与基因组百科全书(KEGG)通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果:筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1(JUN)、肿瘤坏死因子(TNF)、原癌基因(RELA)、干扰素γ(IFNG)、转化生长因子-β1(TGF-β1)等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论:青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。 相似文献
42.
运用可拓工程方法和主成分分析方法建立了福建省第三产业发展水平的综合评判物元模型。模型的输出结果表明:福建省各地区第三产业发展水平差距悬殊;综合关联度将第三产业发展水平划分成4个等级,单指标关联度则揭示了各地区第三产业发展的优、劣势。 相似文献
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Substantial damage to water supply systems, including water delivery pipelines, water treatment plants, reservoirs, and water
storage tanks, was reported after the 1999 Chi–Chi Taiwan Earthquake. This paper first summarizes the damage survey and then
presents the results of seismic fragility analysis for underground pipelines. Construction blueprints of the water delivery
pipelines and repair work orders of 11 townships and cities in the disastrous area were digitized into a Geographical Information
System (GIS) for analysis and assessment. With the aid of the GIS system, we found that PVC pipes made up 86% of water delivery
pipelines while steel, cast iron, ductile iron, PE and others took the rest. Therefore, this paper focuses on the fragility
analysis of PVC pipes. Three different methods were applied to derive the fragility relations between the PVC water pipes
having nominal diameters (approximately inner diameters) greater than or equal to 65 mm and earthquake intensity parameters
such as peak ground acceleration and peak ground velocity. The results were then examined with those of other countries. The
discrepancy between our results and the empirical equation used by HAZUS, an earthquake loss estimation software developed
by the Federal Emergency Management Agency was not significant. 相似文献
45.
The area of Serravalle, sited in the northern part of the town of Vittorio Veneto (TV), NE Italy, has been the target of a
seismic microzonation campaign. 10 seismic stations have been deployed for a 7 months period to record in continuous mode.
Three stations were installed on bedrock outcrops and seven on sedimentary sites with variable cover thickness. Spectral analyses
have been performed on the collected data-set using the Generalized Inversion Technique (GIT, e.g. Andrews, 1986). In particular,
spectral ratios have been calculated for each station relatively to the average of the three reference, bedrock sites. The
spectral ratios provide quantitative estimates of the seismic motion amplifications which occur in each of the monitored sites.
Two sites show high values of amplification, 5 times larger than signal amplitude at the reference sites, in correspondence
of well discernible peak frequencies of 5 Hz. Results for the other stations show smaller amounts of site amplification spreading
over a broad range of frequencies. Sites where the highest amplifications were recorded all lie on the left bank of the Meschio
River and in areas farther away from its outlet into the plain correlating with the presence of thick layers of Quaternary
deposits. 相似文献
46.
R&D投入的区位模式与区域经济发展 总被引:2,自引:1,他引:2
基于对中国R&D投入的区位模式的实证检验,从投入一产出绩效的角度认为集中投入的区位模式具有较强的适宜性。利用聚类分析技术,按照R&D的投入强度和及其对经济的带动效应、科技化效应、产业化效应将中国各省区划分为6类地区,具有代表性的是科技化模式和产业化模式。其中前者适合于技术存置较高的少数地区,而后者具有较强的借鉴意义。 相似文献
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Károly Posgay Tamás Bodoky Zoltán Hajnal Tivadar M. Tóth Tamás Fancsik Endre Hegeds Attila Cs. Kovács Ern Takács 《Geophysical Journal International》2006,167(1):187-203
The geologic origin of subhorizontal reflections, often observed in crustal seismic sections, was investigated by establishing metamorphic facies and strength of rocks in depth, and correlating these properties to seismic reflection sections from eastern Hungary. Estimation of the depths of metamorphic mineral stability zones utilized the principles developed by Fyfe et al. and known geothermal data of the area. The strength versus depth profile was derived by relating local seismic P -wave interval velocities to Meissner et al. 's activation energy. The results show that the series of subhorizontal reflections, observed in the Pannonian Basin, are a consequence of combined metamorphic and rheologic changes in depths. The synthesis of the integrated data set suggests that the retrograde alteration of the pre-Tertiary basement above the percolation threshold was made possible by the softening effect of shear zones and their water-conducting capacity. The subhorizontal reflections of highest energy, of the consolidated crust below the percolation threshold, originate in the depths of greenschist, amphibolite and granulite metamorphic mineral facies, which were formed in geothermal and pressure conditions similar to those existing today. These results imply the overprint of earlier (Variscan) metamorphic sequences of the crust by more recent retrograde metamorphic processes. 相似文献
50.