基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

参数的期望估计及其在形变分析中的应用

利用“参数的期望估计”能准确定位、定量粗差及参数的期望估计不受粗差影响折特殊性质,寻找地壳变形区域和不变形区域,以确定拟稳点,进而进行拟稳变换,分析地菜变,将是一种有效方法。     

Dynamics of Mars-orbiting dust: Effects of light pressure and planetary oblateness

This paper deals with dynamics of impact ejecta from Phobos and Deimos initially on near-circular equatorial orbits around Mars. For particles emitted in a wide size regime of 1 micron and greater, and taking into account the typical particle lifetimes to be less than 100 years, the motion is governed by two perturbing forces: solar radiation pressure and influence of Mars' oblateness. The equations of motion of particles in Lagrangian non-singular elements are deduced and solved, both analytically and numerically, for different-sized ejecta. We state that the coupled effect of both forces above is essential so that on no account can the oblateness of Mars are be neglected. The dynamics of grains prove to be quite different for the ejecta of Phobos and Deimos. For Deimos, the qualitative results are relatively simple and imply oscillations of eccentricity and long-term variations of orbital inclination, with amplitudes and periods both depending on grain size. For Phobos, the dynamics are shown to be much more complicated, and we discuss it in detail. We have found an intriguous peculiar behavior of debris near 300 µm in size. Another finding is that almost all the Phobos ejecta with radii less than 30 µm (against the values of 5 to 20 µm adopted earlier by many authors) should be rapidly lost by collisions with martian surface. The results of the paper may be the base for constructing an improved model of dust belts that presumably exist around Mars.     

短周期仪器记录在远震分析中的应用

地震泼由多种频率成份组成,在其传播过程中。由于地球介质的滤波作用,随着传播距离的增大。高频成份逐渐被衰减。周期越大的成份传播越远。因此,在地震观测上,不同频带的地震仪用于观测不同震中距范围的地震,使仪器较好地响应,就我国台网而言,短周期仪用于地方震、近震的监测,中长周期仪和长周期仪用于远震,极远震的监测,其中长周期仪偏重于记录极远震。但作者在实际分析工作中注意到,短周期仪的记录应用于远震,极远震的分析,显示出独特的作用,充分挖掘和利用短仪资料,将会更加丰富远震、极远震的震相资料。本文以高台地震台的资料为依据,从震中距和震级角度,与中长仪和长仪作比较,对短仪记录远震、极远震的震相及特征作了统计分析与初步探讨,并对新疆地区“影区”地震S波的记录、日本地区地震_PPcP等震相的出现提出了现象的存在,给出了相应的观测结果,以待步一步研究。     

X-ray spectroscopy of stellar coronae

Summary From the early discovery in 1948 of X-rays from the Solar corona, X-ray spectroscopy has proven to be an invaluable tool in studying hot astrophysical and laboratory plasmas. Because the emission line spectra and continua from optically thin plasmas are fairly well known, high-resolution X-ray spectroscopy has its most obvious application in the measurement of optically thin sources such as the coronae of stars. In particular X-ray observations with theEINSTEIN observatory have demonstrated that soft X-ray emitting coronae are a common feature among stars on the cool side of the Hertzsprung-Russell diagram, with the probable exception of single very cool giant and supergiant stars and A-type dwarfs. Observations with the spectrometers aboardEINSTEIN andEXOSAT have shown that data of even modest spectral resolution (/ = 10–100) permit the identification of coronal material at different temperatures whose existence may relate to a range of possible magnetic loop structures in the hot outer atmospheres of these stars. The higher spectral resolution of the next generation of spectrometers aboard NASA'sAXAF and ESA'sXMM will allow to fully resolve the coronal temperature structure and to enable velocity diagnostics and the determination of coronal densities, from which the loop geometry (i.e. surface filling factors and loop lengths) can be derived. In this paper various diagnostic techniques are reviewed and the spectral results fromEINSTEIN andEXOSAT are discussed. A number of spectral simulations forAXAF andXMM, especially high-resolution iron K-shell, L-shell, and2s-2p spectra in the wavelength regions around 1.9 Å, 10 Å, and 100 Å, respectively, are shown to demonstrate the capabilities for temperature, density, and velocity diagnostics. Finally, iron K-shell spectra are simulated for various types of detectors such as microcalorimeter, Nb-junction, and CCD.     

饱和软土压缩曲线的“反常”现象

饱和软土压缩试验时,经常出现压缩曲线“反常”、压缩系数“倒大”的现象。它是土的原始结构发生破坏前后的不同压缩性的客观反映。饱和软土的结构力很微弱,唯质量好的原状土才能见到这种“反常”。应从成孔、取样、测试及资料整理等多个环节保证其工程意义。     

Fracture analysis in the south-western Corinth rift (Greece) and implications on fault hydraulic behavior

This paper reviews the data concerning the fracture network and the hydraulic characteristics of faults in an active zone of the Gulf of Corinth. Pressure gap measured through fault planes shows that in this area the active normal faults (Aigion, Helike) act, at least temporarily and locally, as transversal seal. The analysis of the carbonate cements in the fractures on both the hangingwall and the footwall of the faults also suggests that they have acted as local seals during the whole fault zone evolution. However, the pressure and the characteristics of the water samples measured in the wells indicate that meteoric water circulates from the highest part of the relief to the coast, which means it goes through the fault zones. Field quantitative analysis and core studies from the AIG-10 well have been performed to define both regional and fault-related fracture networks. Then laboratory thin section observations have been done to recognize the different fault rocks characterizing the fault zone components. These two kinds of approach give information on the permeability characteristics of the fault zone. To synthesize the data, a schematic conceptual 3D fluid flow modeling has been performed taking into account fault zone permeability architecture, sedimentation, fluid flow, fault vertical offset and meteoric water influx, as well as compaction water flow. This modeling allows us to fit all the data with a model where the fault segments act as a seal whereas the relays between these segments allow for the regional flow from the Peloponnese topographic highs to the coast.     

Attenuation of aqueous metal transport at two natural acid rock drainage occurrences in the Yukon Territory, Canada

Naturally acidic drainage associated with pyritic black shale has been observed in many locations in the Yukon Territory. While not necessarily linked to known mineral deposits, most of these natural acid rock drainage occurrences show elevated dissolved concentrations of trace elements, especially zinc, nickel, copper, cadmium and arsenic. Based on field observations, microbial investigation, chemical analyses and geochemical modeling, the fate and transport of potentially deleterious elements at two natural acid drainage occurrences with slightly different settings are examined. The Macintosh Creek is a small, acidic stream （pH 2.98-3.40）, 2 km long, located in the Macmillan Pass area of east-central Yukon amidst known sedimentary exhalative massive sulfide mineralization but remains undisturbed by exploration activities. Its trace metal content is apparently derived from groundwater discharges, which gave as much as 5.0, 2.5, 0.7, 0.13 and 0.03 mg/L ofZn, Ni, Cu and As, respectively. Interaction and sorption reactions with algal mats, biofilms and iron oxyhydroxides appear to be the dominant mechanisms attenuating aqueous contaminant transport along the stream. Cryogenic precipitation further consolidates the ferricrete formation and reduces the mobility of the sorbed metals. The tributaries of the Engineering Creek along the Dempster Highway in northern Yukon drain through a series of dolomite, phyllite, argillite, limestone, black shale, sandstone and conglomerate with no known concentration of mineralization. In this area, the water chemistry fully reflects the local geology with acidic streams invariably associated with black shale occurrences. Groundwater seeps in the headwaters area of the km-180 Creek completely enclosed in black shale gave pH 3.0 and as much as 148, 39, 2.9 and 9.1 mg/L of Zn, Ni, Cu and As, respectively. Sorption with iron oxyhydroxide and organic matter appear to dominate the attenuation of contaminant transport along the stream. However, once entered into carbonate-dominated terrains, secondary carbonate minerals exercise additional geochemical control on the local water chemistry as a result of neutralization.     

Genesis of monazite and Y zoning in garnet from the Black Hills, South Dakota

The paragenesis of monazite in metapelitic rocks from the contact aureole of the Harney Peak Granite, Black Hills, South Dakota, was investigated using zoning patterns of monazite and garnet, electron microprobe dating of monazite, bulk-rock compositions, and major phase mineral equilibria. The area is characterized by low-pressure and high-temperature metamorphism with metamorphic zones ranging from garnet to sillimanite zones. Garnet porphyroblasts containing euhedral Y annuli are observed from the garnet to sillimanite zones. Although major phase mineral equilibria predict resorption of garnet at the staurolite isograd and regrowth at the andalusite isograd, textural and mass balance analyses suggest that the formation of the Y annuli is not related to the resorption-and-regrowth of garnet having formed instead during garnet growth in the garnet zone. Monazite grains in Black Hills pelites were divided into two generations on the basis of zoning patterns of Y and U: monazite 1 with low-Y and -U and monazite 2 with high-Y and -U. Monazite 1 occurs in the garnet zone and persists into the sillimanite zone as cores shielded by monazite 2 which starts to form in the andalusite zone. Pelites containing garnet porphyroblasts with Y annuli and monazite 1 with patchy Th zoning are more calcic than those with garnet with no Y annuli and monazite with concentric Th zoning. Monazite 1 is attributed to breakdown of allanite in the garnet zone, additionally giving rise to the Y annuli observed in garnet. Monazite 2 grows in the andalusite zone, probably at the expense of garnet and monazite 1 in the andalusite and sillimanite zones. The ages of the two different generations of monazite are within the precision of chemical dating of electron microprobe. The electron microprobe ages of all monazites from the Black Hills show a single ca. 1713 Ma population, close to the intrusion age of the Harney Peak Granite (1715 Ma). This study demonstrates that Y zoning in garnet and monazite are critical to the interpretation of monazite petrogenesis and therefore monazite ages.     

Secular variations of the upper crust composition: Implication of geochemical data on the Upper Precambrian shales from the Southern Urals western flank and Uchur-Maya region

In the mid-1980s, it was concluded based on geochemical study that Th, Sc, La concentrations and ratios Th/Sc, La/Sc and Eu/Eu* did not wary significantly in the post-Archean time. It was impossible to judge about compositional variations of upper crust during the Riphean and Vendian, because data of that time characterized a limited number of samples from the post-Archean basins of Australia, New Zealand, and Antarctic. Considered in this work are variations of Eu/Eu*, LREE/HREE, Th/Sc, and La/Sc ratios in Upper Precambrian fine-grained siliciclastic rock of the Southern Urals western flank (Bashkirian meganticlinorium) and Uchur-Maya region (Uchur-Maya plate and Yudoma-Maya belt). As is established, only the Eu anomaly in the studied siliciclastic rocks is practically identical to this parameter of the average post-Archean shale. Three other parameters plot on the Riphean-Vendian variation curves with positive and negative excursions of diverse magnitude, which do not coincide always in time. It is assumed that these excursions likely mark stages of local geodynamic activity, destruction of pre-Riphean cratons, and progressing recycling of sedimentary material during the Riphean.