海洋溴酚衍生物LXQ-5的PTP1B的结合作用和体内降糖活性研究

二型糖尿病是一种代谢性疾病,对人类健康造成了极大的威胁。蛋白酪氨酸磷酸酶1B(PTP1B)是胰岛素信号通路中的负调控蛋白酶,是二型糖尿病治疗的重要研究靶点。本文利用酶动力学实验和分子互作技术检测了溴酚衍生物LXQ-5的PTP1B抑制作用类型和体外特异性结合作用的特点。测定糖尿病小鼠口服给药后的空腹血糖水平和血清中糖化血红蛋白以及糖化血清蛋白水平等糖尿病相关指标的变化,研究了化合物LXQ-5在小鼠体内的降糖活性。实验结果表明, LXQ-5是PTP1B的一种非竞争性抑制剂,且在体外能够与PTP1B特异性结合。LXQ-5在糖尿病小鼠体内能显著的降低空腹血糖水平和血清中糖化血红蛋白、糖化血清蛋白含量,在新型降糖药物的研发方面具有重要的研究价值。     

多尺度地理加权回归的地表温度降尺度研究

由于星载热红外传感器研发技术的局限性,单一传感器尚不能提供兼具高频次、高空间分辨率地表温度数据。协同其他遥感辅助数据,对低空间分辨率、高时间频次地表温度产品开展降尺度研究成为了解决这一难题的有效途径。然而由于现有地表温度降尺度方法未充分考虑不同地表状态参数对地表温度空间分异格局的尺度影响差异,降尺度后的地表温度数据在异质性景观区域存在精度较差和空间纹理不清晰的问题。鉴于此,本文以北京和张掖地区的8期MODIS地表温度产品为例,通过引入多尺度地理加权回归MGWR（Multiscale Geographically Weighted Regression）来分析归一化植被指数NDVI、数字高程模型DEM、坡度和经纬度对地表温度空间格局影响的尺度差异,提出一种针对MODIS地表温度产品的空间降尺度算法,并与TsHARP算法、多元线性回归算法、地理加权回归算法和随机森林回归算法进行定量对比。结果表明,基于MGWR模型的地表温度降尺度转换函数能够良好地揭示多种地表状态参数与地表温度间的不同作用关系,其中NDVI和坡度对地表温度分布具有全局影响,DEM和经纬度对地表温度呈现出了局域性作用。与4种代表性方法相比,基于MGWR算法降尺度后的100 m分辨率地表温度数据具有更好的空间纹理,在城镇和沙漠等温度异质性明显地区保障了清晰的景观纹理;另外,对于所选研究区的8期MODIS地表温度产品而言,利用MGWR算法降尺度后的地表温度均拥有更好的精度,在0—1 K误差级别下的面积占比均大于57%,均方根误差RMSE（Root-Mean-Square Error）均小于2.85 K,决定系数R²（coefficient of determination）均大于0.88。     

Impact of hillslope-derived sediment supply on drainage basin development in small watersheds at the northern border of the central Alps of Switzerland

This paper explores the effects of hillslope mobility on the evolution of a 10-km² drainage basin located at the northern border of the Swiss Alps. It uses geomorphologic maps and the results of numerical models that are based on the shear stress formulation for fluvial erosion and linear diffusion for hillslope processes. The geomorphic data suggest the presence of landscapes with specific cross-sectional geometries reflecting variations in the relationships between processes in channels and on hillslopes. In the headwaters, the landscape displays parabolic cross-sectional geometries indicating that mass delivered to channels by hillslope processes is efficiently removed. In the trunk stream portion, the landscape is (i) V-shaped if the downslope flux of mass is balanced by erosion in channels (i.e. if mass delivered to channels by hillslope processes is efficiently removed) and (ii) U-shaped if in-channel accumulation of hillslope-derived material occurs. This latter situation indicates a non-balanced mass flux between processes in channels and on hillslopes.Information about the spatial pattern of the postglacial depth of erosion allows comparative estimates to be made about the erosional efficiency for the various landscapes that were mapped in the study area. The data suggest that the erosional potential and sediment discharge are reduced for the situation of a non-balanced mass flux between processes in channels and on hillslopes. These findings are also supported by the numerical model. Indeed, the model results show that high hillslope mobility tends to reduce the hillslope relief and to inhibit dissection and formation of channels. In contrast, stable hillslopes tend to promote fluvial incision, and the hillslope relief increases. The model results also show that very low erosional resistance of bedrock promotes backward erosion and steepening of channel profiles in headwaters. Beyond that, the model reveals that sediment discharge generally increases with decreasing erosional resistance of bedrock, but that this increase decays exponentially with increasing magnitudes of fluvial and hillslope mobilities. Very high hillslope diffusivities even tend to reduce the erosional potential of the whole watershed. It appears that besides rates of base-level lowering, factors limiting sediment discharge might be the nonlinear relationships between processes in channels and on hillslopes.     

Modern Diatom Assemblages in Surface Sediments from Estuarine Systemsin the Southeastern Buenos Aires Province, Argentina

Paleoecological reconstructions of Holocene sea-level changes in Argentinean coastal regions were based mainly on ecological data gathered from other regions, as there was a lack of information on modern estuarine diatom distributions. The aim of the present work was to assess the spatial variation of diatom assemblages in two representative estuaries of Argentina in order to gather ecological information for paleoecological reconstructions in the region. The two selected estuaries have different geomorphologic features and salinity regimes: Mar Chiquita Lagoon is shallow, which prevents the development of a stable salinity gradient as it occurs in the Quequén Grande River. Surface sediment samples were taken from selected stations representative of the environmental gradient from the inlet to the inner reaches of both estuaries. Cluster analysis defined three diatom zones at Mar Chiquita: marine/brackish assemblages dominate the inlet (zone I), where salinity, tidal range and current speed are higher. The brackish/freshwater tychoplankton Staurosira construens var. venter and Staurosirella pinnata dominate the inner lagoon (zone II), where environmental conditions are very variable and concentrations of suspended sediments are higher. Brackish/freshwater euryhaline diatoms dominate the headwaters (zone III). On the other hand, the Quequén Grande River was divided into three diatom zones: coastal taxa are distributed at the inlet (zone I), while the middle estuary (zone II) is dominated by brackish/freshwater euryhaline taxa. At the upper estuary region (zone III), freshwater diatoms dominate, and the halophobous Nitzschia denticula increased in abundance values. Diatom distributions were most closely related to the salinity gradient at Quequén Grande River than at Mar Chiquita Lagoon. Fossil data of a sequence from Mar Chiquita Lagoon (Las Gallinas Creek) were compared to the modern data set in order to search for analogies between fossil and modern diatom assemblages. DCA results showed that fossil diatom assemblages have modern counterparts. Most diatom assemblages of Las Gallinas Creek fall within Mar Chiquita zone III, representing a shallow brackish/freshwater environment, with low salinity fluctuations (~1–9‰) and no tidal influence. Therefore, our modern diatom data provide useful analogs to interpret paleoenvironments in the region.     

Study of the Contributions of Non‐Specific and Specific Interactions during Fluoxetine Adsorption onto Activated Carbons

The adsorption of fluoxetine onto activated carbons (ACs) prepared from almond tree pruning by steam and CO₂ activation under different temperature conditions (650–950°C), was studied. In both series increasing the temperature caused an increase in the BET apparent surface area, yielding ACs with S_BET up to 870 and 710 m² g^?1 after steam and CO₂ activation, respectively. Also, a slight widening of the porosity was found in both cases. In order to modify the functionality of the ACs, two of them were impregnated with triethylenediamine (TEDA) prior to the adsorption process, which caused a decrease in the AC apparent surface mainly due to micropore blockage. The fluoxetine adsorption isotherms at 25°C showed maximum adsorption capacities between 110 and 224 mg g^?1. The adsorption isotherms were analyzed using Langmuir and Freundlich models. Although the impregnation reduced the pore volume, it did not cause a decrease in the fluoxetine maximum adsorption capacity, but a modification in the adsorption mechanism was observed.     

基于MIROC/WRF嵌套模式的中国气候变化预估

开展了基于全球模式MIROC嵌套区域气候模式WRF的动力降尺度模拟试验,预估了IPCC SRES A1B排放情景下中国21世纪中期(2041~2060年)和末期(2081~2100年)的气候变化。21世纪中期:全国大部分区域年平均地表气温(下文简称气温)上升2~4°C,升温幅度较大的是在北方地区和青藏高原。年平均降水在华南和东北大部基本没有增加,甚至有所减少,在西北及长江和黄河的中下游地区有所增加。气温的标准差总体上是北方大于南方,全国的大值区位于青藏高原,表明北方地区和青藏高原的气温年际变率较大。降水年际变率较大的是华北和西北地区。21世纪末期:全国大部分区域升温在4°C以上,升温幅度较大的依然是北方地区和青藏高原。其中,青藏高原大部升温超过7°C。从季节来看,春季和冬季升温要多于夏季和秋季。降水整体上是增加的,在南方部分地区有所减少,特别是在西南地区和青藏高原的南部。气温年际变率依然是北方大于南方,全国的大值区同样位于青藏高原。华北和西北还是降水年际变率较大的地区。     

中国东部夏季降水准两年振荡空间分布及背景场特征

本文采用经验正交函数展开(EOF)及相关分析等方法,使用中国气象局整编的160站1951~2005年月平均降水资料和NCEP/NCAR再分析资料研究了中国东部夏季降水准两年周期振荡的空间模态及其大气环流背景场.结果表明:(1)中国地区降水季节性差异明显,夏季是主要的降水期并具有明显的准两年周期振荡(TBO)特征,中国东部地区是降水TBO方差变化最大的区域.(2)中国东部夏季降水TBO存在两个主要的空间模态,第1模态以27°N为界南北成反位相的变化关系,降水振幅较大;第2模态降水振幅相对较小,大值中心位于河套—华北地区.(3)形成中国东部夏季降水TBO的两个主要空间模态环流背景场明显不同.第1模态与西太平洋海温成正相关,与东太平洋海温成负相关.第2模态则主要与日本海附近的海温成正相关.当夏季降水TBO以江淮偏多时(第1模态),西太平洋海温偏高,东太平洋海温偏低,中国东部及沿海上空850 hPa有异常反气旋,500 hPa高度相关场东亚上空呈正负正波列特征,200 hPa南亚高压加强,西风急流位置偏南.当夏季降水TBO降水位置偏北时(第2模态),中国东部及沿海上空有异常气旋,200 hPa南亚高压偏弱,西风急流位置偏北.     

论中国地震台网测得的面波震级

文中使用了一个新的量规函数σ300（Δ）,它是基于面波传播理论,考虑了面波的几何扩散、非弹性吸收、频散衰减以及面波优势周期随震中距的变化导出的,取全球平均Q=300。在震中距Δ=20°—160°的范围内与IASPEI推荐的面波震级的量规函数σIASPEI（Δ）一致,又推广了σIASPEI（Δ）的震中距使用范围,从1.0°—179°,以及可使用的面波周期范围（7.5—30s）,因此它更适合我国由中周期宽频带SK仪组成的台网情况。若采用此量规函数σ300（Δ）和进行方位角改正,则可使我国台网测出的Ms与国际地震中心（ISC）测出的一致,震级误差降到0.19级,此误差与苏联台网的误差一样。     

青藏高原夏季地面感热通量与高原低涡生成的可能联系

利用NCEP/NCAR地面感热通量再分析格点资料以及MICAPS天气图资料识别的高原低涡资料集,分析了1981—2010年青藏高原夏季地面感热通量线性倾向分布的空间分布特征,重点讨论了夏季高原地面感热通量与同期高原低涡生成频数的可能联系尤其是空间相关性。结果表明,近30 a夏季感热通量的线性倾向分布具有区域性差异,感热减少趋势在高原分布较广且负值中心明显,感热增加主要分布在高原西北部和东部。夏季地面感热通量与同期高原低涡生成频数呈高度正相关;感热通量强年,高原主体东部地区低层呈气旋式环流,高层为辐散气流,高原上空上升气流偏强,感热通量弱年的情形与之相反。地面感热加热强度与高原低涡的生成频数在空间上有明显联系。     

Issues in the application of Digital Surface Model data to correct the terrain illumination effects in Landsat images

The accuracy of topographic correction of Landsat data based on a Digital Surface Model (DSM) depends on the quality, scale and spatial resolution of the DSM data used and the co-registration between the DSM and the satellite image. A physics-based bidirectional reflectance distribution function (BRDF) and atmospheric correction model in conjunction with a 1-second DSM was used to conduct the analysis in this paper. The results show that for the examples used from Australia, the 1-second DSM, can provide an effective product for this task. However, it was found that some remaining artefacts in the DSM data, originally due to radar shadow, can still cause significant local errors in the correction. Where they occur, false shadows and over-corrected surface reflectance factors can be observed. More generally, accurate co-registration between satellite images and DSM data was found to be critical for effective correction. Mis-registration by one or two pixels could lead to large errors of retrieved surface reflectance factors in gully and ridge areas. Using low-resolution DSM data in conjunction with high-resolution satellite images will also fail to correct significant terrain components where they occur at the finer scales of the satellite images. DSM resolution appropriate to the resolution of satellite image and the roughness of the terrain is needed for effective results, and the rougher the terrain, the more critical will be the accurate registration.