Biodegradability of the Anti-tumour Agents 5-Fluorouracil,Cytarabine, and Gemcitabine: Impact of the Chemical Structure and Synergistic Toxicity with Hospital Effluent

Most anti-tumour agents are known to be carcinogenic, mutagenic, teratogenic, embryotoxic or fetotoxic. Only little is known about the environmental impact of pharmaceuticals. Unmetabolized active substances are excreted and will show up in municipal wastewater. Therefore, we examined the biodegradability of the widely used anti-tumour agent 5-fluorouracil (5-FU), also as an example for assessing the impact of hospital effluent on the biodegradation of a test compound. The biodegradability of the structurally similar anti-tumour agents cytarabine and gemcitabine was also examined. Test systems used were the closed bottle test (OECD 301 D) and the modified Zahn-Wellens test (OECD 302 B). 5-FU was not biodegradable in the closed bottle test (CBT) nor in the Zahn-Wellens test (ZWT). At the highest concentration of 5-FU, with hospital effluent an inhibition of the degradation of substances present in hospital effluent was observed, probably as a result of a synergistic effect by 5-FU with antibiotics present in hospital sewage. Gemcitabine was biodegraded 42% in the CBT. The prolongation of the test period to 40 days only improved the result to 45%. In the ZWT, the biodegradation of gemcitabine was 50%. Cytarabine was partially biodegraded in the CBT (50%), but only after an adaptation period of 20 days. After a test prolongation to 40 days, the degree of biodegradation was 80%. In the ZWT, the biodegradability was > 95% after only a few days.     

内蒙古地区地震活动度S值特征分析

采用定量描述地震活动强弱程度的地震活动度方法，研究了内蒙古地区1970年以来中强地震的分布特征和活动规律，发现内蒙古地区S值存在5年周期的起伏活动规律。在分区研究区的基础上，内蒙古地区从西到东，地震活动度S值呈现有规律的强一弱交替特征。     

用远震接收函数研究滇西地区的深部结构

滇西地区地处欧亚板块碰撞或俯冲的边界地带，曾受到多期构造运动的影响，其地质环境和构造背景十分复杂，是我国地震活动比较活跃的地区之一. 本文选用国家、地方和流动数字台网的16个台站的远震记录. 其中PASSCAL甚宽频带流动地震台站4个，提取有效接收函数近2 000条. 两条测线的直线距离分别为650 km和450 km， 横切了滇西地区的一些主要构造单元. 研究表明，怒江断裂可能是一条具有俯冲性质的缝合线. 川滇菱形块体东西两侧的分界线¾红河断裂和小江断裂可能是直立的缝合线或碰撞带. 攀西构造带仍具有大陆裂谷的特征，即地表凹陷、上地幔隆起. 滇西地区的构造格局具有一定的规律性，造山带与缝合线相间分布. 滇西地区由北向南地壳厚度渐次减薄，S波速度整体偏低.      

2001年昆仑山口西8.1级地震同震形变场特征的初步分析a

利用差分干涉雷达测量技术获取的宏观震中区的同震形变场，结合对地震活动性、震源机制、野外考察等资料分析，对昆仑山口西8.1级地震同震形变场特征进行了研究. 结果表明:宏观震中位于库赛湖东北侧，宏观震中区发震断层可分为两个形变中心区域，其中西段长约42 km，东段长约48 km，整个发震断层主破裂段长90 km；由干涉形变条纹分布格局可清楚地判断出发震断层的左旋走滑特征；断层两盘变形特征不同，南盘变形程度明显大于北盘；宏观震中附近最大斜距向位移量为288.4 cm，最小斜距向位移量为224.0 cm，宏观震中发震断层最大左旋水平位错为738.1 cm，最小地面左旋水平位错为551.8 cm.      

Kinetics of the Gas-Phase Reactions of OH Radicals, NO3 Radicals and O3 with Three C7-Carbonyls Formed From The Atmospheric Reactions of Myrcene, Ocimene and Terpinolene

Rate constants for the gas-phase reactions of OH radicals, NO₃ radicals and O₃ with the C₇-carbonyl compounds 4-methylenehex-5-enal [CH₂=CHC(=CH₂)CH₂CH₂CHO], (3Z)- and (3E)-4-methylhexa-3,5-dienal [CH₂=CHC(CH₃)=CHCH₂CHO] and 4-methylcyclohex-3-en-1-one, which are products of the atmospheric degradations of myrcene, Z- and E-ocimene and terpinolene, respectively, have been measured at 296 ± 2 K and atmospheric pressure of air using relative rate methods. The rate constants obtained (in cm³ molecule^–1 s^–1 units) were: for 4-methylenehex-5-enal, (1.55 ± 0.15) × 10^–10, (4.75 ± 0.35) × 10^–13 and (1.46 ± 0.12) × 10^–17 for the OH radical, NO₃ radical and O₃ reactions, respectively; for (3Z)-4-methylhexa-3,5-dienal: (1.61 ± 0.35) × 10^–10, (2.17 ± 0.30) × 10^–12, and (4.13 ± 0.81) × 10^–17 for the OH radical, NO₃ radical and O₃ reactions, respectively; for (3E)-4-methylhexa-3,5-dienal: (2.52 ± 0.65) × 10^–10, (1.75 ± 0.27) × 10^–12, and (5.36 ± 0.28) × 10^–17 for the OH radical, NO₃ radical and O₃ reactions, respectively; and for 4-methylcyclohex-3-en-1-one: (1.10 ± 0.19) × 10^–10, (1.81 ± 0.35) × 10^–12, and (6.98 ± 0.40) × 10^–17 for the OH radical, NO₃ radical and O₃ reactions, respectively. These carbonyl compounds are all reactive in the troposphere, with daytime reaction with the OH radical and nighttime reaction with the NO₃ radical being predicted to dominate as loss processes and with estimated lifetimes of about an hour or less.     

The Frozen Soils and Devastating Characteristics of West Kunlun Mountains Pass Ms 8.1 Earthquake Area in 2001

The investigation on damages to frozen soil sites during the West Kunlun Mountains Pass earthquake with Ms 8.1 in 2001 shows that the frozen soil in the seismic area is composed mainly of moraine, alluvial deposit, diluvial deposit and lacustrine deposit with the depth varying greatly along the earthquake rupture zone. The deformation and rupture of frozen soil sites are mainly in the form of coseismic fracture zones caused by tectonic motion and fissures,liquefaction, seismic subsidence and collapse resulting from ground motion. The earthquake fracture zones on the surface are main brittle deformations, which, under the effect of sinlstral strike-slip movement, are represented by shear fissures, tensional cracks and compressive bulges. The distribution and configuration patterns of deformation and rupture such as fissures, liquefaction, seismic subsidence and landslides are all related to the ambient rock and soil conditions of the earthquake area. The distribution of earthquake damage is characterized by large-scale rupture zones, rapid intensity attenuation along the Qinghai-Xizang (Tibet) Highway, where buildings distribute and predominant effect of rock and soil conditions.     

应用GMS5多通道云图估计降水技术的研究

对近两年来5～8月中国东部地区120多个测站雨量观测资料和对应4400多幅GMS-5四个通道云图的研究发现：红外亮温的时间、空间变率、红外和水汽通道亮温差等云图衍生资料对消除卷云，弥补夜间缺少可见光云图的不足起到明显作用。从而，应用双判据双重MOS多元回归法建立四通道云图因子、衍生因子与降水量之间的回归方程，进行6小时分级降水估计。为了进一步消除厚卷云和特殊地形的影响，提出使用逐日实时资料自动建立多元回归方程估计降水量，从而对双判据双重MOS多元回归法估计结果进行校正。上海中心气象台的业务使用表明，总体估计的准确率达70％左右。     

应用6S模式对EOS-MODIS可见光到中红外波段的大气订正

应用6S辐射传输模式对MODIS可见光到中红外波段的反射率进行大气订正，订正过程分两步进行:首先设定地表为朗伯体，再应用二向反射模型BRDF进行订正，订正结果与美国MODIS研究组应用MAS实验结果进行比较表明，两者变化趋势是一致的；经过臭氧、水汽、气溶胶等散射吸收订正，对于一定范围的反射率，大气订正使植被区红光波段反射率ρ₁降低、近红外波段反射率ρ₂增加，蓝光波段反射率ρ₃降低；大气订正后，归一化植被指数I_NDV较大气订正前有所增加，增加的最大值为0.104，抗土壤-大气植被指数IEV值略有减小，减小的最大值为0.005。     

98.7湖北特大暴雨的天气分析与降水模拟

1998年7月20～23日，湖北省南部发生了一次持续性特大暴雨过程，采用双向嵌套的非静力中尺度数值模式(MM5)对这次强暴雨过程进行初步模拟试验。结果表明，粗、细网格均能较好地模拟出雨带的走向和变动以及武汉地区的暴雨中心，尤其是嵌套域(细网格)模拟的降水强度比粗网格有明显改进，和实际观测结果更接近；另外，对引发这次特大暴雨的对流层低层的中尺度系统也能够很好地模拟出来。     

2-[2-(6-氯苯并噻唑)偶氮]-5-二乙氨基苯甲酸与镍的显色反应

研究了2-[2-(6-氯苯并噻唑)偶氮]-5-二乙氨基苯甲酸(6-Cl-BTAEB)与Ni2+的显色反应。结果表明:在pH4.5～7.6的HAc-NaAc缓冲溶液中及十二烷基硫酸钠存在下,试剂与Ni2+形成稳定的蓝紫色配合物,组成为n(Ni2+)∶n(6-Cl-BTAEB)=1∶2,最大吸收波长650nm,表观摩尔吸光系数为1.59×105L·mol-1·cm-1,Ni2+浓度在0～400μg/L内符合比尔定律。用铝合金和合金钢中的微量镍验证该分析方法,所得结果与推荐值相符,6次测定的RSD<2%。