甘草和连翘对牙鲆CYP3A 活性影响的研究

研究甘草(Glycyrrhiza uralensis)和连翘(Forsythia suspensa)对牙鲆(Paralichthys olivaceus)肝细胞色素P4503A(CYP3A)活性的影响。将牙鲆随机分为3组,即对照组、甘草组和连翘组,对照组每日口灌0.9%的生理盐水,试验组每日1次口灌甘草30 mg/kg和连翘100 mg/kg,连续口灌6 d,第7天时,采用直接测定法和间接测定法(探针药物)进行CYP3A酶活性的测定。结果显示:在肝微粒体水平上,甘草和连翘均可明显提高红霉素-N-脱甲基酶活性,分别提高了1.79倍、4.87倍。与对照组相比,甘草组和连翘组氨苯砜的半衰期分别降低了4.51%(P0.05)和36.8%(P0.01);药时曲线下面积分别减小了8.28%(P0.05)和32.3%(P0.01);总清除率分别增加了5.63%(P0.05)和99.3%(P0.01)。说明连翘对牙鲆CYP3A的活性具有极显著诱导作用,甘草诱导作用不显著。提示其他药物与连翘合用时,其有效性和安全性可能会受到影响。     

Species delimitation in the green algal genus Codium (Bryopsidales) from Korea using DNA barcoding

Codium, one of the largest marine green algal genera, is difficult to delimit species boundary accurately based on morphological identification only. DNA barcoding is a powerful tool for discriminating species of seaweeds. The plastid elongation factor TU(tuf A) is considered as maker to perform DNA barcoding of green algal species than rbc L gene due to universality and rapid evolution rate. We conducted DNA barcoding application to Codium specimens from the Jeju Island, Korea to overcome the limit of morphological identification and to confirm the species diversity. As a result of applying tuf A marker, we newly generated fifty-five tuf A barcodes to resolve eight species. Tuf A marker exhibited 6.1%–21.8% interspecific divergences, wider than the gap of rbc L exon 1,3.5%–11.5%. Molecular analysis of rbc L exon 1 sequences of Codium revealed eight distinct species like tuf A analysis separated in five phylogenetic groups. DNA barcoding of the genus Codium using tuf A marker is more helpful to overcome the limit of morphological identification, and this is more potential to reveal cryptic species and to resolve the relationships among subspecies than rbc L analysis alone. The complement of tuf A barcoding and rbc L analyses including morphology for the genus Codium in the northwestern Pacific will give much more reliable achievement for discovering species diversity and resolving the phylogenetic relationships.     

基于HJ-1A高光谱的黄河口碱蓬和柽柳盖度反演模型研究

碱蓬和柽柳是黄河口湿地典型的盐生植物类型,是多种保护珍禽的主要栖息地,具有景观尺度较小、分布广且多混生的特点。应用覆盖黄河口北部潮滩的HJ-1A高光谱遥感影像,基于现场测量的端元光谱和从遥感影像中使用顺序最大角凸锥法(SAMCC)自动提取的端元光谱,应用线性光谱分解法(LSU)、正交子空间投影法(OSP)、匹配滤波法(MF)、最小能量约束法(CEM)和自适应一致估计法(ACE)5种不同光谱解混方法进行混合像元光谱解混,对比两种方法得到的端元光谱分别对碱蓬和柽柳盖度的反演能力,并给出相应的反演模型。结果显示:(1)现场测量端元光谱取得了较好的碱蓬和柽柳盖度反演结果,其中应用LSU方法的光谱解混结果与现场测量盖度的决定系数对于碱蓬和柽柳分别达到了0.88和0.95;(2)两种端元获取方式的光谱解混结果中,LSU和OSP方法均获得了较高的相关性,ACE解混方法的相关性都最低;(3)SAMCC方法提取端元光谱对柽柳的分解结果与现场测量盖度的相关性远高于碱蓬。     

数字滤波技术在射电天文测量中的应用

随着数字技术的发展，数字信号处理芯片的速度越来越快，这为高速数字滤波的实时实现提供了可能。简要阐述了数字滤波的原理，并对两种数字滤波的实现方法进行了分析；给出了数字滤波较模拟滤波的优势；介绍了数字滤波在射电天文测量中的各种应用。     

Chandra observations of neutron stars: an overview

We present an overview of Chandra X-ray Observatory observations of neutron stars. The outstanding spatial and spectral resolution of this great observatory have allowed for observations of unprecedented clarity and accuracy. Many of these observations have provided new insights into neutron star physics. We present an admittedly biased and overly brief review of these observations, highlighting some new discoveries made possible by the Observatory’s unique capabilities. This includes our analysis of recent multiwavelength observations of the putative pulsar and its pulsar-wind nebula in the IC443 SNR.      

An atlas of the optical spectrum of supernova 1987A in the large magellanic cloud

Photographic spectra of SN1987A in the LMC have been obtained from 1987 February 25 to 1988 June 30. Microdensitometer tracings of these have been reduced to intensity and corrections for instrumental response have been applied to the spectra. This paper presents these data in an atlas format, discusses the reduction procedures in detail, and presents radial velocity measurements of selected lines in the spectra     

EFFECT OF PERPENDICULAR A.C. ELECTRIC FIELD ON THE OBLIQUE WHISTLER MODE INSTABILITY IN THE EARTH’S MAGNETOSPHERE

The elements of dielectric tensor and dispersion relation for obliquely propagating whistler waves with finite in an infinite magnetoplasma are obtained for a kappa distribution in the presence of perpendicular a.c. electric field. Integrals and modified plasma dispersion functions are reduced in power series form. Numerical calculations have been performed to obtain temporal growth rate and real frequencies of the plasma waves for magnetospheric plasma, using linear theory of dispersion relation. The effect and modification introduced by the perpendicular a.c. electric field on the temporal growth rates, real frequencies and resonance condition are discussed for kappa and Maxwellian distributions. Our results and their interpretation are compared with known whistler observations obtained by ground-based techniques and satellite observations.     

Neutral hydrogen gas in interacting galaxies: the NGC 1511 galaxy group

We present H  i line and 20-cm radio continuum observations of the NGC 1511 galaxy group obtained with the Australia Telescope Compact Array. The data reveal an extended, rather disturbed H  i distribution for the peculiar starburst galaxy NGC 1511 and a narrow bridge to its small companion galaxy, NGC 1511B, which has been severely distorted by the interaction/collision between the two galaxies. No stellar counterpart to the gaseous bridge has been detected. In addition, we find that the peculiar optical ridge to the east of NGC 1511 is probably the stellar remnant of a galaxy completely disrupted by interactions with NGC 1511. The slightly more distant neighbour, NGC 1511A, shows a regular H  i velocity field and no obvious signs of interactions.
Radio continuum emission from NGC 1511 reveals three prominent sources on top of a more diffuse, extended distribution. We derive an overall star formation rate of  7 M_⊙ yr⁻¹  . The most enhanced star formation is found in the south-eastern part of the disc, coincident with several bright H  ii regions, and closest to the peculiar optical ridge. No continuum emission was detected in the companions, but NGC 1511B appears to show an H  ii region at its faint western edge, closest to NGC 1511. The group displays a prime example of interaction-induced star formation activity.