Subtidal sea level and current variations in the northern reach of San Francisco Bay

Analyses of sea level and current-meter data using digital filters and a variety of statistical methods show a variety of phenomena related to non-local coastal forcing and local tidal forcing in the northern reach of San Francisco Bay, a partially mixed estuary. Low-frequency variations in sea level are dominated by non-local variations in coastal sea level and also show a smaller influence from tidally induced fortnightly sea level variations. Low-frequency currents demonstrate a gravitational circulation which is modified by changes in tidal-current speed over the spring-neap tidal cycle. Transients in gravitational circulation induce internal oscillations with periods of two to four days.     

大气垂直折射与时序垂直角值的谱分析

本文介绍了对时序垂直角观测值进行谱分析的方法和所得到的结论。使以往对于大气折射影响及其变化规律的定性认识得以定量化。     

Distinct climate change synchronous with Heinrich event one, recorded by stable oxygen and carbon isotopic compositions in stalagmites from China

Uranium-series dating of oxygen and carbon isotope records for stalagmite SJ3 collected in Songjia Cave, central China, shows significant variation in past climate and environment during the period 20-10 ka. Stalagmite SJ3 is located more than 1000 km inland of the coastal Hulu Cave in East China and more than 700 km north of the Dongge Cave in Southwest China and, despite minor differences, displays a clear first-order similarity with the Hulu and Dongge records. The coldest climatic phase since the Last Glacial Maximum, which is associated with the Heinrich Event 1 in the North Atlantic region, was clearly recorded in SJ3 between 17.6 and 14.5 ka, in good agreement in timing, duration and extent with the records from Hulu and Dongge caves and the Greenland ice core. The results indicate that there have been synchronous and significant climatic changes across monsoonal China and strong teleconnections between the North Atlantic and East Asia regions during the period 20-10 ka. This is much different from the Holocene Optimum which shows a time shift of more than several thousands years from southeast coastal to inland China. It is likely that temperature change at northern high latitudes during glacial periods exerts stronger influence on the Asian summer monsoon relative to insolation and appears to be capable of perturbing large-scale atmospheric/oceanic circulation patterns in the Northern Hemisphere and thus monsoonal rainfall and paleovegetation in East Asia. Climatic signals in the North Atlantic region propagate rapidly to East Asia during glacial periods by influencing the winter land-sea temperature contrast in the East Asian monsoon region.     

Detection of free vertical convection and double-diffusion in groundwater monitoring wells with geophysical borehole measurements

Two algorithms for in-situ detection and identification of vertical free convective and double-diffusive flows in groundwater monitoring wells or boreholes are proposed. With one algorithm the causes (driving forces) and with the other one the effects (convection or double-diffusion) of vertical transport processes can be detected based on geophysical borehole measurements in the water column. Five density-driven flow processes are identified: thermal, solutal, and thermosolutal convection leading to an equalization, as well as saltfingers and diffusive layering leading to an intensification of a vertical density gradient. The occurrence of density-driven transport processes could be proven in many groundwater monitoring wells and boreholes; especially shallow sections of boreholes or groundwater monitoring wells are affected dramatically by such vertical flows. Deep sections are also impaired as the critical threshold for the onset of a density-driven flow is considerably low. In monitoring wells or boreholes, several sections with different types of density-driven vertical flows may exist at the same time. Results from experimental investigations in a medium-scale testing facility with high aspect ratio (height/radius = 19) and from numerical modeling of a water column agree well with paramters of in-situ detected convection cells.     

气举反循环采矿方法单井试验及应用探讨

湖南道县一个矿区,铁锰矿体储量约2200万t。由于复杂的水文地质和工程地质条件,从20世纪70年代发现后,一直没有开采。笔者通过多年大直径工程井的实践经验,查阅国内外资料后,提出了钻井-气举反循环法试开采的方法,并在现场进行了单孔开采试验,获得了比较满意的效果。以该矿体Ⅱ号矿为例,介绍了钻井-气举反循环法采矿的适用条件、工艺过程以及试采情况,并就以后大面积开采提出了若干技术措施。     

GYD-300型全液压动力头工程钻机的研制

GYD-300型全液压动力头工程钻机为全液压驱动,动力头反循环式机型。液压系统采用插装阀集成结构,电液复合操作。使用PC控制监测系统,适时检测孔底各相关压力,对不同地层进行范围设置,实现钻进过程中孔底的自动、手动恒压钻进。重点介绍了该钻机的结构特点、实验情况、主要技术参数等。     

中国对虾血细胞酶细胞化学的初步研究

运用电镜酶细胞化学技术 ,对中国对虾 (Penaeus chinensis)的血细胞和血清中的酚氧化酶、酸性磷酸酶、碱性磷酸酶和过氧化物酶的酶活性部位进行标记。实验结果显示 :酚氧化酶主要以酶原形式存在于大颗粒细胞的颗粒体中 ,酸性磷酸酶和碱性磷酸酶以酶原形式存在于小颗粒细胞的颗粒体中。健康虾和患病虾血细胞中酶活性的表现形式不尽相同 ,在病理情况下 ,颗粒细胞能以细胞解体的方式 ,排出细胞内的颗粒 ,转化成有活性的酶 ,以此提高血淋巴中这几种酶的活性。透明细胞可以吞噬排放颗粒后的颗粒细胞 ,透明细胞中由高尔基体合成的酸性磷酸酶等溶酶体酶主要用于透明细胞的细胞内消化作用。研究认为 :3种血细胞因含有不同的免疫酶以及酶的作用方式不同而具有不同的免疫功能     

斜向波对直立式防波堤堤头作用的试验研究

直立式防波堤堤头在斜向波浪作用下波浪力的计算在现行的技术规范中尚属空白。通过物理模型试验给出了堤头结构设计所需的波压分布图，指出了波浪入射方向和地形对堤头所受波浪力的贡献有时可以超过波高和波周期，根据现行规范按波浪正向入射计算堤头所受的波浪力偏于安全。     

南印度洋SST与南亚季风环流年代际变化的研究

利用美国NCEP全球大气再分析资料和JONES全球海表面温度异常(SSTA)资料，分析了南印度洋SSTA和南亚季风环流年代际变化的特征。研究发现，无论是南印度洋副热带海水辐合区的SST还是赤道以北非洲西海岸附近上升运动海区的SST的长期变化趋势，除了准3-5年的变化以外，还存在着明显的年代际的变化。对于全球最显著南亚季风环流的分析表明，南亚季风环流也存在明显的年代际时间尺度的变化。与南太平洋SST的年代际变化相比，南印度洋SST的变化周期要相对短一些。通过分析南半球冷空气年代际活动的特征发现，冷空气与南印度洋SST年代际时间尺度的变化具有密切的联系。     

基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。