基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

Centrifugal test of a road embankment built after new dredger fill on thick marine clay

Abstract

The construction of a 100-km road network is planned on a land reclamation area in the Oujiang Estuary in China. The embankment had a height of 4 m and a base width of 60 m. The reclamation area is newly filled by a 3-m dredger fill on a 48-m thick layer of marine clay. Estimation of the settlement of the future road network is difficult. To guide the construction of the road network, a 1/100-scale centrifuge model test was performed with a marine clay sample from the construction site to simulate the layered settlements and evaluate the drainage effect of prefabricated vertical drains in the dredger fill in the following 10 years. The results of the centrifuge modeling test are verified by 10-month in situ monitoring, which shows agreement between the centrifuge modeling test results and the in situ results. The test results indicate that additional time is needed to reinforce the newly added dredger fill by the surcharge preloading method to uplift the elevation of the reclamation area with dredger fill.     

ISD单片语音录/放器件及电路设计

指出ＩＳＤ单片语言器件的独特之处，是采用直接模拟存储技术，语音信号以其原本的模拟形式直接存入模拟量存储器中并长远保存。省去了传统的Ａ／Ｄ和Ｄ／Ａ数模转换机制，能高保真的将语音内容再生。这是一种高新录／放技术。另外，给出的ＩＳＤ基本录／放电路十分简单易用。可方便地为微机系统、测控仪表电器和广播等设备所采用，使设备具有高效功能     

船舶受冲击力作用时的水动力试验研究

根据冲量相似的要求进行船舶在冲击作用下的模型试验，并将模型试验结果与理论计算及实际试验进行了对比和分析。     

南麂站定常波风浪波高与风速的经验关系

本文以南麂海洋站１９８３～１９９０年风、浪的实测资料为依据，建立了南麂海城春、夏、秋、冬季定常波风浪波高与风速的经验关系式。检验结果表明，曲线回归显著，计算值与实测值吻合良好。文中还对偏ＮＮＥ向和偏ＳＳＷ向计算波高随风速增大的快慢，同一方向在同一风速作用下计算波高的季节变化及其机理作了初浅的讨论。     

中国对虾育苗池和养成池微型污着生物群落的研究

于１９９２年４－１０月在山东省青岛市黄岛前湾育苗场和胶南市红石崖镇邵家村养殖场，采用载玻片挂片和对中国对虾现场取样的方法，研究中国对虾育苗池和养成池载玻片挂 表面和对体表微型污着生物群落的组成和发展。     

嵌入式Linux技术在海洋自动观测系统中的应用研究

随着Linux技术逐步走向成熟，嵌入式Linux技术在海洋自动观测系统中的应用将全面提高海洋观测系统整体性能，降低系统开发成本，进一步推进我国海洋自动观测系统产权自主化的建设。文章就如何研制适用于海洋自动观测系统的嵌入式Linux系统进行了论述。     

Test Study on Current Force on Mooring Ships

In respect of an offshore berthing pillar, the test study result of current force acting on mooring ships is described in this paper. Empirical and semi-empirical relationships of current force coefficient are given according to the angle between the flow direction and the ship's longitudinal axis, which are coincident with the result of theoretical analysis.     

Mechanisms controlling the temporal variation of the sea ice edge in the Southern Ocean

This paper examines the mechanism controlling the short time-scale variation of sea ice cover over the Southern Ocean. Sea ice concentration and ice velocity datasets derived from images of the Defense Meteorological Satellite Program (DMSP) Special Sensor Microwave Imager (SSM/I) are employed to reveal this mechanism. The contribution of both dynamic and thermodynamic processes to the change in ice edge location is examined by comparing the meridional velocity of ice edge displacement and sea ice drift. In the winter expansion phase, the thermodynamic process of new ice production off the ice edge plays an important role in daily advances of ice cover, whereas daily retreats are mostly due to southward ice drift. On the other hand, both advance and retreat of ice edges in the spring contraction phase are mostly caused by the dynamic process of the ice drift. Based on the above mechanism and the linear relation between the degree of ice production at the ice edge and northward wind speed, the seasonal advance of ice cover can be roughly reproduced using the meridional velocity of ice drift at the ice edge.     

使用简易测试平台检测马哈克扭力仪的性能

本文描述简易测试平台的原理与制作，对马哈克MAIHAK MDS－820型扭力仪检测模拟负载的准确性进行探讨。