Responses of a Mediterranean soft bottom community to short-term (1993-1996) hydrological changes in the Rhone river

The polychaete fauna of muddy bottoms off the Rhone delta (NW Mediterranean) was seasonally sampled at two sites at 70 m depth, from 1993 to 1996. During this period, five severe flood events occurred. A clustering analysis (distance coefficient of Whittaker) and three way fixed factor ANOVAs (site x season x year) showed strong year-to-year changes in species density and community structure, changes that masked seasonal variations. Total density increased by a factor of 3 and density of most species significantly increased following the first flooding event. Changes in the community structure were due to the successive dominance of a few species. The opportunistic species, such as Cossura sp., Mediomastus sp. and Polycirrus sp., exhibited peaks in density 1-3 months after the flood. These peaks were followed by a drastic decline. For species with a long life span, such as Sternaspis scutata, a slower but continuous increase in density was observed which was maintained for several months. The density fluctuations of these species exhibited a good correlation with river flow with time lags of 1-2 years. The successional dynamics observed are explained according to the geographical origin of the floods and the biology and feeding ecology of species.     

基于网络药理学和分子对接技术探究柯里拉京治疗卵巢癌的关键靶点及分子机制

目的：采用网络药理学和分子对接技术相结合的方法探究柯里拉京（Cor）治疗卵巢癌的关键作用靶点和分子机制。方法：利用PharmMapper、TargetNet及Swiss Target Prediction在线工具预测Cor的作用靶点,通过OMIM、TTD、CTD、DisGenet、PharmGKB及MalaCards数据库获取卵巢癌相关的疾病靶点,并将药物靶点与疾病靶点取交集得到Cor治疗卵巢癌的预测靶点。借助STRING数据库、Cytoscape 软件构建蛋白质-蛋白质相互作用（PPI）网络,并采用CentiScape插件筛选出PPI网络中的核心靶点。运用GEPIA和Kaplan-Meier Plotter在线平台分别对这些核心靶点进行基因表达差异分析和生存分析,以明确Cor治疗卵巢癌的关键靶点。利用DAVID数据库进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析。运用Autodock Vina软件进行正向分子对接,预测关键靶点和Cor之间的结合活性。结果：Cor治疗卵巢癌的预测作用靶点共24个,其中RAC-α丝氨酸/苏氨酸蛋白激酶(AKT1)、表皮生长因子受体(EGFR)、雌激素受体1(ESR1)、原癌基因酪氨酸蛋白激酶(SRC)是Cor治疗卵巢癌的关键靶点,主要涉及血管内皮生长因子(VEGF)信号通路、缺氧诱导因子-1(HIF-1)信号通路及叉头样转录因子(FoxO)信号通路,可能通过调控细胞凋亡、细胞增殖、血管内皮细胞迁移等生物过程而发挥治疗卵巢癌的作用。分子对接结果显示,Cor与预测靶点之间具有较好的亲和力,表明通过网络药理学预测作用靶点的方法具有良好的可靠性。结论：Cor是通过多靶点、多通路的协同作用来干预多个生物过程,从而发挥其抗卵巢癌疗效,为进一步研究其治疗卵巢癌的分子机制提供了新的线索。     

厄尔尼诺的发生与行星运动

厄尔尼诺(El Ni(?)o)现象是海-气耦合系统异常变化的表现,其起因可能不是唯一的,行星运动对地球运动的影响可能会导致El Ni(?)o的发生。根据4个半世纪内El Ni(?)o发生的历史资料,分析其发生和行星运动的关系,得出的结论是:木星赤纬的变化和火星大冲与El Ni(?)o。的发生有显著的关系,表明这2颗行星的运动可能影响El Ni(?)o的发生。文中还根据分析结桌和El Ni(?)o混沌机制的观点,探讨了行星运动对海-气系统变化的影响机制。     

珠江口盆地东沙隆起的沉降史及其动力机制

根据东沙隆起及其周围钻井资料的一维构造沉降对比分析,结合前人在基底、盖层及断裂等方面的研究,将东沙隆起地区的构造演化分为5个阶段:自垩纪挤压阶段、古新世-早渐新世伸展断陷阶段、早渐新世末期抬升剥蚀阶段、晚渐新世-中新世快速的裂后沉降阶段、晚中新世以来断块升降阶段.认为下地壳高速层是促使早渐新世末期抬升剥蚀的重要因素,而...     

Modified PIC Method for Sea Ice Dynamics

The sea ice cover displays various dynamical characteristics such as breakup, rafting, and ridging under external forces. To model the ice dynamic process accurately, the effective numerical modeling method should be established. In this paper, a modified particle-in-cell （PIC） method for sea ice dynamics is developed coupling the finite difference （FD） method and smoothed particle hydrodynamics （SPH）. In this method, the ice cover is first discretized into a series of lagrangian ice particles which have their own sizes, thicknesses, concentrations and velocities. The ice thickness and concentration at Eulerian grid positions are obtained by interpolation with the Gaussian function from their surrounding ice particles. The momentum of ice cover is solved with FD approach to obtain the Eulerian cell velocity, which is used to estimate the ice particle velocity with the Gaussian function also. The thickness and concentration of ice particles are adjnsted with particle mass density and smooth length, which are adjusted with the redistribution of ice particles. With the above modified PIC method, numerical simulations for ice motion in an idealized rectangular basin and the ice dynamics in the Bohai Sea are carried out. These simulations show that this modified PIC method is applicable to sea ice dynamics simulation.     

Marine tether dynamics: retrieval and deployment from a heaving platform

A tether management system of a winch module in a marine environment is proposed. For the purpose of this study the subsea body is considered as a mass attached at the free end of a long tether which is wrapped around a circular drum controlled by an external torque. The winch is considered mounted on a heaving platform. The effect of the heaving platform on the motions of the drum, tether and attached mass are studied with respect to the longitudinal vibrations of the tether in one dimension. The hydrodynamic effects are considered on the deployed portion of the tether and the tethered mass, both of which are assumed submerged in otherwise still water. The resulting nonlinear system of equations of motion is developed and solved numerically for an example of a marine tether system. The effect of the tether extensibility on the operation threshold of the system is identified. Comparison with an inextensible tether case is provided. The numerical results and their analysis for the retrieval/deployment of the system are presented.     

鲁苏榴辉岩套的特征及其动力学演化

鲁苏榴辉岩套以广泛分布各类榴辉岩、密切伴生石榴石橄榄岩、石榴石麻粒岩等高压岩石组合 ,普遍发育韧性变形带 ,大量出露燕山晚期碱性花岗岩及深源脉岩为特征。它已经历三迭纪早期华南陆块与华北陆块的碰撞事件、大陆逆掩推覆构造事件及后期白垩纪早期开始的大陆伸展构造事件 ,是我国华南陆块与华北陆块之间的重要过渡单元。