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71.
目的:基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法:通过基因表达汇编(GEO)数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体(GO)功能及京都基因与基因组百科全书(KEGG)通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果:骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶(MAPK)信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论:骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。 相似文献
72.
本文以赤道东太平洋海温作为主导因子,分析其与东亚温带气旋的关系。得出:高海温多气旋,低海温少气旋的对应关系较为明显。并进一步对不符合这种主要关系的年份从环流型。下垫面海温等作了分类鉴别分析。 相似文献
73.
74.
本文提出一个以带有定时器的低功耗微处理机为主体的温度记录器。其定时器用于开动微处理机,可由一个开关定为0.5、1、3或30分钟。仪器通过处理一个电容器向热敏电阻放电的时间来测量温度。仪器在工作中能显示温度值,并把温度值保存在微处理机的RAM之中。总共资料容量为2816次测值,量程为0~35℃,精度±0.1℃,分辨±0.02℃。 温度记录器具有液晶显示器,可直接读出温度值,配有标准计算机接口RS-232,能把保存的资料方便地倒给个人计算机。 这项工作是伍兹霍尔海洋研究所A.Bradley博士指导的。他提出的原理对研制可靠而廉价的温度记录器是一条新的途径。 相似文献
75.
Abstract. The oxygen consumption of Eudendrium glomeratum was measured monthly, throughout the period of active presence of the species in the field, to obtain indications on its physiological condition in the different phases of the cycle. Sets of one hundred polyps were assayed in the laboratory under normothermic (according to field temperature: 14–19°C) and hyperthermic conditions (22–25°C). The different response to identical temperatures at the extremes of the cycle, together with a differential ability to face stressful conditions in the same periods, suggests that other factors, besides temperature, regulate the seasonal cycle of Eudendrium glomeratum. 相似文献
76.
77.
Toru?Iwata Keiko?Yoshikawa Katsutoshi?Nishimura Yoshihisa?Higuchi Takao?Yamashita Shigeru?Kato Eiji?OhtakiEmail author 《Journal of Oceanography》2004,60(6):995-1000
The measurements of the vertical transport of CO2 were carried out over the Sea of Japan using the specially designed pier of Kyoto University on September 20 to 22, 2000. CO2 fluxes were measured by the eddy correlation and aerodynamic techniques. Both techniques showed comparable CO2 fluxes during sea breeze conditions: −0.001 to −0.08 mg m−2s−1 with the mean of −0.05 mg m−2s−1. This means that the measuring site satisfies the fetch requirement for meteorological observations under sea breeze conditions. Moreover, the eddy diffusivity coefficient used in the aerodynamic technique is found to be consistent with the coefficient used in the eddy correlation technique. The present result leads us to conclude that the aerodynamic technique may be applicable to underway CO2 flux measurements over the ocean and may be used in place of the bulk technique. The important point is the need to maintain a measuring accuracy of CO2 concentration difference of the order of 0.1 ppmv on the research vessels or the buoys. 相似文献
78.
Song Jinming 《海洋学报(英文版)》2003,22(1):57-68
Carbon cycle is connected with the most important environmental issue of Global Change.As one of the major carbon reservoirs, oceans play an important part in the carbon cycle. In recent years, iron seems to give us a good news that oceanic iron fertilization could stimulate biological productivity as CO2 sink of human-produced CO2. Oceanic iron fertilization experiments have verified that adding iron into high nutrient low chlorophyll (HNLC) seawaters can increase phytoplankton production and export organic carbon, and hence increase carbon sink of anthropogenic CO2, to reduce global warming. In sixty days, the export organic carbon could reach 10 000 times for adding iron by model prediction and in situ experiment, i.e. the atmospheric CO2 uptake and inorganic carbon drawdown in upper seawaters also have the same magnitude. Therefore, oceanic iron fertilization is one of the strategies for increasing carbon sink of anthropogenic CO2. The paper is focused on the iron fertilization, especially in situ o 相似文献
79.
Jennifer L. Mercer Meixun Zhao Steven M. Colman 《Estuarine, Coastal and Shelf Science》2005,63(4):675-682
Alkenone unsaturation indices (UK37 and UK′37) have long been used as proxies for surface water temperature in the open ocean. Recent studies have suggested that in other marine environments, variables other than temperature may affect both the production of alkenones and the values of the indices. Here, we present the results of a reconnaissance field study in which alkenones were extracted from particulate matter filtered from the water column in Chesapeake Bay during 2000 and 2001. A multivariate analysis shows a strong positive correlation between UK37 (and UK′37) values and temperature, and a significant negative correlation between UK37 (and UK′37) values and nitrate concentrations. However, temperature and nitrate concentrations also co-vary significantly. The temperature vs. UK37 relationships (UK37=0.018 (T)−0.162, R2=0.84, UK′37=0.013 (T)−0.04, R2=0.80) have lower slopes than the open-ocean equations of Prahl et al. [1988. Further evaluation of long-chain alkenones as indicators of paleoceanographic conditions. Geochimica et Cosmochimica Acta 52, 2303–2310] and Müller et al. [1998. Calibration of the alkenone paleotemperature index UK′37 based on core-tops from the eastern South Atlantic and the global ocean (60°N–60°S). Geochimica et Cosmochimica Acta 62, 1757–1772], but are similar to the relationships found in controlled studies with elevated nutrient levels and higher nitrate:phosphate (N:P) ratios. This implies that high nutrient levels in Chesapeake Bay have either lowered the UK37 vs. temperature slope, or nutrient levels are the main controller of the UK37 index. In addition, particularly high abundances (>5% of total C37 alkenones) of the tetra-unsaturated ketone, C37:4, were found when water temperatures reached 25 °C or higher, thus posing further questions about the controls on alkenone production as well as the biochemical roles of alkenones. 相似文献
80.