山西能源重化工基地建设研究

山西能源重化工基地建设关系到全国四个现代化的实现,被列为国家重点建设工程,制定了《山西能源重化工基地综合规划》。本文分析了80年代山西省经济建设的成就与问题。提出了“整体创新,综合开发”,把山西能源重化工基地建设成内陆经济开放区的战略大思路,为此,90年代应完成11项大型经济战略工程,同时展望了经济发展改革前景。     

泥浆性能对定向钻进铺管孔壁稳定性的影响

本文通过对泥浆性能的分析,特别是对泥浆流变参数的控制与调节在定向钻进非开挖铺管中的作用及其护壁原理的分析,简要阐述了泥浆性能对定向钻进铺管孔壁稳定性的影响,对非开挖定向钻进铺管施工有一定的指导意义。     

在工作程度高的地区如何筛选矿致磁异常

分析了在工作程度高的地区进一步筛选矿致磁异常的可能性;提出了在工作程度高的地区筛选矿致磁异常的优先顺序建议。     

江西省永平铜矿西部排土场极限堆载高度确定

国内外对排土场极限堆载高度的理论计算缺乏研究,目前尚无成熟的统一理论计算方法。文章结合永平铜矿西部排土场的工程实例,在进行边坡工程地质条件勘察与排土场岩土物理力学性质试验研究的基础上,采用数值计算方法对排土场进行了分层堆载数值模拟计算。通过对计算结果的分析,得到位移、塑性区与安全系数随堆载高度的变化规律,并确定了该排土场的极限堆载高度。     

矿区控制网布网方案的选择

用计算机模拟法,讨论了控制网不同观测量的平差结果,提出了选择矿区控制网方案的原则.     

An integrable case of a rotational motion analogous to that of Lagrange and Poisson for a gyrostat in a Newtonian force field

The scope of the present paper is to provide analytic solutions to the problem of the attitude evolution of a symmetric gyrostat about a fixed point in a central Newtonian force field when the potential function isV ⁽²⁾.We assume that the center of mass and the gyrostatic moment are on the axis of symmetry and that the initial conditions are the following: (t ₀)=₀, (t ₀)=₀, (t ₀)=(t ₀)=₀, ₁(t ₀)=0, ₂(t ₀)=0 and ₃(t ₀)= ₃ ⁰ .The problem is integrated when the third component of the total angular momentum is different from zero (B ₁ 0). There now appear equilibrium solutions that did not exist in the caseB ₁=0, which can be determined in function of the value ofl ₃ ^r (the third component of the gyrostatic momentum).The possible types of solutions (elliptic, trigonometric, stationary) depend upon the nature of the roots of the functiong(u). The solutions for Euler angles are given in terms of functions of the timet. If we cancel the third component of the gyrostatic momentum (l ₃ ^r =0), the obtained solutions are valid for rigid bodies.     

The arrangement in mean elements space of the periodic orbits close to that of the Moon

In a simplified model of the Earth-Moon-Sun system based on the restricted circular 3-dimensional 3-body problem, it is possible to find numerically a set of 8 periodic orbits whose time evolutions closely resemble that of the Moon's orbit. These orbits have a period of 223 synodic months (i.e. the period of the Saros cycle known for more than two millennia as a means of predicting eclipses), and are characterized by a secular rotation of the argument of perigee . Periodic orbits of longer durations exhibiting this last feature are very abundant in Earth-Moon-Sun dynamical models. Their arrangement in the space of the mean orbital elements- for various values of the lunar mean motion is presented.     

A stability study of asteroid families near the 3:1 and 5:2 resonance with Jupiter

By using theD-criterion Lindblad (1992) has identified 14 asteroid families from a sample of 4100 numbered asteroids with proper elements from Milani and Kneevi (1990). Taxonomic types and other physical properties for a significant number of objects in five of the families show strong homogeneity within each family, further strengthening their internal relationship.To test the hypothesis of a common origin in, e.g., a catastrophic collision event, we have set out to integrate the orbits of the members of the Maria, Dora and Oppavia-Gefion families over some 10⁶ years. The mean distance for the Maria family is close to the 3:1 mean-motion resonance with Jupiter, while the other two families lie close to the 5:2 resonance.We used a simplified solar system model which included the perturbations by Jupiter and Saturn only and implemented Everhart's variable stepsize integrator RA15. All close encounters between the family members (within 0.1 AU) were recorded as well. Preliminary results from integrations over 4×10⁵ years are presented here.The statistics of close encounters show pronounced peaks for several members within each family, while for others no significant levels above the background of random encounters or even very low frequencies were found. This indicates a subclustering within the families. Quite a lot of very close (<0.005 AU) mutual encounters are found, which suggest that, at least for the larger members in a family, the mutual gravitational interactions could be of some importance for the real orbital evolutions.The encounter statistics between the Dora and Oppavia family members suggest a possible interrelationship between this two groups.     

基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。